Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Ruben Vazquez"'
Autor:
Carola Elisa Heesemann Rosenkilde, Ditte Olsen Lützhøft, Ruben Vazquez-Uribe, Morten Otto Alexander Sommer
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
Gut bacteria are known to produce bacteriocins to inhibit the growth of other bacteria. Consequently, bacteriocins have attracted increased attention as potential microbiome-editing tools. In this study we examine the inhibitory spectrum of 75 class
Externí odkaz:
https://doaj.org/article/809e82b4d03144eb8780c0503cc9688d
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background Interest in the use of engineered microbes to deliver therapeutic activities has increased in recent years. The probiotic yeast Saccharomyces boulardii has been investigated for production of therapeutics in the gastrointestinal t
Externí odkaz:
https://doaj.org/article/0cf96817042447be8c1590fca0d75c92
Autor:
Sarunas Tumas, Trine Sundebo Meldgaard, Troels Holger Vaaben, Sara Suarez Hernandez, Annemette Tengstedt Rasmussen, Ruben Vazquez-Uribe, Sine Reker Hadrup, Morten O. A. Sommer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract In this study we performed a step-wise optimization of biologically active IL-2 for delivery using E. coli Nissle 1917. Engineering of the strain was coupled with an in vitro cell assay to measure the biological activity of microbially produ
Externí odkaz:
https://doaj.org/article/1b7a75507437425b9f7c1544ff1af6d3
Autor:
Valeria Iannone, Ambrin Farizah Babu, Johnson Lok, Carlos Gómez-Gallego, Giuseppe D'Auria, Ruben Vazquez-Uribe, Troels Holger Vaaben, Mareike Bongers, Santtu Mikkonen, Maija Vaittinen, Ida Tikkanen, Mikko Kettunen, Anton Klåvus, Ratika Sehgal, Dorota Kaminska, Jussi Pihlajamaki, Kati Hanhineva, Hani El-Nezami, Morten Otto Alexander Sommer, Marjukka Kolehmainen
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101823- (2023)
Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is the most prevalent liver disease globally, yet no therapies are approved. The effects of Escherichia coli Nis
Externí odkaz:
https://doaj.org/article/e3dd49cbb92443919ba14a867061e16d
Autor:
Bastian Seelbinder, Zoltan Lohinai, Ruben Vazquez-Uribe, Sascha Brunke, Xiuqiang Chen, Mohammad Mirhakkak, Silvia Lopez-Escalera, Balazs Dome, Zsolt Megyesfalvi, Judit Berta, Gabriella Galffy, Edit Dulka, Anja Wellejus, Glen J. Weiss, Michael Bauer, Bernhard Hube, Morten O. A. Sommer, Gianni Panagiotou
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Candida species overgrowth in the human gut is considered a prerequisite for invasive candidiasis, but our understanding of gut bacteria promoting or restricting this overgrowth is still limited. By integrating cross-sectional mycobiome and
Externí odkaz:
https://doaj.org/article/995d19354eac486bafefacd3d3f6112b
Autor:
Karl Alex Hedin, Vanessa Emily Rees, Hongbin Zhang, Vibeke Kruse, Ruben Vazquez-Uribe, Morten Otto Alexander Sommer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Mouse models are commonly used to study the colonisation profiles of microorganisms introduced to the gastrointestinal tract. Three commonly used mouse models include conventional, germ-free, and antibiotic-treated mice. However, colonisatio
Externí odkaz:
https://doaj.org/article/be46e261a407491b896af1ba7bfb6baf
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
The human gastrointestinal tract is a complex and dynamic environment, playing a crucial role in human health. Microorganisms engineered to express a therapeutic activity have emerged as a novel modality to manage numerous diseases. Such advanced mic
Externí odkaz:
https://doaj.org/article/d631c645ec964b668279c2563b7808a5
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
One of the biggest challenges for oral drug absorption is the epithelial barrier of the gastrointestinal tract. The use of cell-penetrating peptides (CPPs) to modulate the epithelial barrier function is known to be an effective strategy to improve dr
Externí odkaz:
https://doaj.org/article/823cbc55caf14812a7722dde708d38c6
Autor:
Bastian Seelbinder, Jiarui Chen, Sascha Brunke, Ruben Vazquez-Uribe, Rakesh Santhaman, Anne-Christin Meyer, Felipe Senne de Oliveira Lino, Ka-Fai Chan, Daniel Loos, Lejla Imamovic, Chi-Ching Tsang, Rex Pui-kin Lam, Siddharth Sridhar, Kang Kang, Bernhard Hube, Patrick Chiu-yat Woo, Morten Otto Alexander Sommer, Gianni Panagiotou
Publikováno v:
Microbiome, Vol 8, Iss 1, Pp 1-20 (2020)
Abstract Background Antibiotic treatment has a well-established detrimental effect on the gut bacterial composition, but effects on the fungal community are less clear. Bacteria in the lumen of the gastrointestinal tract may limit fungal colonization
Externí odkaz:
https://doaj.org/article/094b3dea44204e7f8f97543a71e9fbb1
Autor:
Yoshitaro Heshiki, Ruben Vazquez-Uribe, Jin Li, Yueqiong Ni, Scott Quainoo, Lejla Imamovic, Jun Li, Maria Sørensen, Billy K. C. Chow, Glen J. Weiss, Aimin Xu, Morten O. A. Sommer, Gianni Panagiotou
Publikováno v:
Microbiome, Vol 8, Iss 1, Pp 1-14 (2020)
Abstract The gut microbiota has the potential to influence the efficacy of cancer therapy. Here, we investigated the contribution of the intestinal microbiome on treatment outcomes in a heterogeneous cohort that included multiple cancer types to iden
Externí odkaz:
https://doaj.org/article/c3ba9ef56ca241138cd55ca95f6630e9