Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ruben Soto Acosta"'
Autor:
Ivan V. Kuzmin, Ruben Soto Acosta, Layne Pruitt, Perry T. Wasdin, Kritika Kedarinath, Keziah R. Hernandez, Kristyn A. Gonzales, Kharighan Hill, Nicole G. Weidner, Chad Mire, Taylor B. Engdahl, Woohyun J. Moon, Vsevolod Popov, James E. Crowe, Ivelin S. Georgiev, Mariano A. Garcia-Blanco, Robert K. Abbott, Alexander Bukreyev
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The rodent-borne Andes virus (ANDV) causes a severe disease in humans. We developed an ANDV mRNA vaccine based on the M segment of the viral genome, either with regular uridine (U-mRNA) or N1-methylpseudouridine (m1Ψ-mRNA). Female mice immu
Externí odkaz:
https://doaj.org/article/b9d9f5258a8943afbcc90d9e051b9c63
Publikováno v:
Molecules, Vol 27, Iss 18, p 6109 (2022)
To search for Zika virus (ZIKV) antivirals, we have further explored previously reported 7H-pyrrolo[2,3-d]pyrimidines by examining an alternative substitution pattern of their central scaffold, leading to compound 5 with low micromolar antiviral acti
Externí odkaz:
https://doaj.org/article/f944d6773a5b4f69b532981979d310bc
Autor:
Ruben Soto-Acosta, Tiffany C. Edwards, Christine D. Dreis, Venkatramana D. Krishna, Maxim C-J. Cheeran, Li Qiu, Jiashu Xie, Laurent F. Bonnac, Robert J. Geraghty
Publikováno v:
Viruses, Vol 13, Iss 12, p 2508 (2021)
Broad-spectrum antiviral therapies hold promise as a first-line defense against emerging viruses by blunting illness severity and spread until vaccines and virus-specific antivirals are developed. The nucleobase favipiravir, often discussed as a broa
Externí odkaz:
https://doaj.org/article/4ed7d485443143e19662aa390f9377fb
Publikováno v:
Molecules, Vol 26, Iss 13, p 3779 (2021)
Discovery of compound 1 as a Zika virus (ZIKV) inhibitor has prompted us to investigate its 7H-pyrrolo[2,3-d]pyrimidine scaffold, revealing structural features that elicit antiviral activity. Furthermore, we have demonstrated that 9H-purine or 1H-pyr
Externí odkaz:
https://doaj.org/article/4eb03b91a3d74e30a93c520ef7dcb865
Autor:
Ruben Soto-Acosta, Xuping Xie, Chao Shan, Coleman K Baker, Pei-Yong Shi, Shannan L Rossi, Mariano A Garcia-Blanco, Shelton Bradrick
Publikováno v:
eLife, Vol 7 (2018)
Subgenomic flaviviral RNA (sfRNA) accumulates during infection due to incomplete degradation of viral genomes and interacts with cellular proteins to promote infection. Here we identify host proteins that bind the Zika virus (ZIKV) sfRNA. We identifi
Externí odkaz:
https://doaj.org/article/200e02bf34774f20a077dc4c0581b8e2
Autor:
Julien Pompon, Menchie Manuel, Geok Kee Ng, Benjamin Wong, Chao Shan, Gayathri Manokaran, Ruben Soto-Acosta, Shelton S Bradrick, Eng Eong Ooi, Dorothée Missé, Pei-Yong Shi, Mariano A Garcia-Blanco
Publikováno v:
PLoS Pathogens, Vol 13, Iss 7, p e1006535 (2017)
Globally re-emerging dengue viruses are transmitted from human-to-human by Aedes mosquitoes. While viral determinants of human pathogenicity have been defined, there is a lack of knowledge of how dengue viruses influence mosquito transmission. Identi
Externí odkaz:
https://doaj.org/article/2e0386c04b854bb8ac00eaedbdbae51a
8‐Hydroxy‐1,6‐naphthyridine‐7‐carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease
Autor:
Eunkyung Jung, Ryuichi Majima, Tiffany C. Edwards, Ruben Soto‐Acosta, Robert J. Geraghty, Zhengqiang Wang
Publikováno v:
ChemMedChem. 17
Human cytomegalovirus (HCMV) replication requires a metal-dependent endonuclease at the C-terminus of pUL89 (pUL89-C) for viral genome packaging and cleavage. We have previously shown that pUL89-C can be pharmacologically inhibited with designed meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb28b3903582ce44515b2eb4294d8b76
https://doi.org/10.1002/cmdc.202200334
https://doi.org/10.1002/cmdc.202200334
Autor:
Eunkyung Jung, Ruben Soto-Acosta, Jiashu Xie, Daniel J. Wilson, Christine D. Dreis, Ryuichi Majima, Tiffany C. Edwards, Robert J. Geraghty, Liqiang Chen
Publikováno v:
ACS medicinal chemistry letters. 13(9)
Taking advantage of the uniquely constricted active site of SARS-CoV-2 Nsp14 methyltransferase, we have designed bisubstrate inhibitors interacting with the SAM and RNA substrate binding pockets. Our efforts have led to nanomolar inhibitors including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890ca183711d8bd8d8195ccfec7b95d9
https://pubmed.ncbi.nlm.nih.gov/36097498
https://pubmed.ncbi.nlm.nih.gov/36097498
Publikováno v:
Medicinal Chemistry Research
The AAA+ (ATPase associated with various cellular activities) protein p97, also called valosin-containing protein, is a hexameric ring ATPase and uses ATP hydrolysis to unfold or extract proteins from biological complexes. Many cellular processes are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5805f7c4fc9191c606eb7c10cf93a7e5
https://doi.org/10.1007/s00044-020-02679-1
https://doi.org/10.1007/s00044-020-02679-1
Autor:
Mariano A. Garcia-Blanco, Massimo Caputi, Sandhya Sharma, Shelton S. Bradrick, Alamgir Kabir, Waseem Asghar, Ruben Soto-Acosta
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
Zika virus (ZIKV) is an emerging flavivirus transmitted to humans by Aedes mosquitos. ZIKV can be transmitted from mother to fetus during pregnancy and can cause microcephaly and other birth defects. Effective vaccines for Zika are yet to be approved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426e498109da88ca42e0495fba33f2ff
http://link.springer.com/article/10.1038/s41598-020-68635-6
http://link.springer.com/article/10.1038/s41598-020-68635-6