Výsledky vyhledávání - "Ruben Schmidt"

Akademický článek

Intermediate filament network perturbation in the C. elegans intestine causes systemic dysfunctions

Autor: Florian Geisler, Sanne Remmelzwaal, Vera Jankowski, Ruben Schmidt, Mike Boxem, Rudolf E Leube

Publikováno v: eLife, Vol 12 (2023)

Intermediate filaments (IFs) are major components of the metazoan cytoskeleton. A long-standing debate concerns the question whether IF network organization only reflects or also determines cell and tissue function. Using Caenorhabditis elegans, we h

Externí odkaz: https://doaj.org/article/f1dc74546afd4969b89eb036bf0b9e2c

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Akademický článek

ERM-1 Phosphorylation and NRFL-1 Redundantly Control Lumen Formation in the C. elegans Intestine

Autor: Jorian J. Sepers, João J. Ramalho, Jason R. Kroll, Ruben Schmidt, Mike Boxem

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Reorganization of the plasma membrane and underlying actin cytoskeleton into specialized domains is essential for the functioning of most polarized cells in animals. Proteins of the ezrin-radixin-moesin (ERM) and Na+/H+ exchanger 3 regulating factor

Externí odkaz: https://doaj.org/article/9f750acc43c04299b78d0bdf46c2e385

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Akademický článek

Caenorhabditis elegans LET-413 Scribble is essential in the epidermis for growth, viability, and directional outgrowth of epithelial seam cells.

Autor: Amalia Riga, Janine Cravo, Ruben Schmidt, Helena R Pires, Victoria G Castiglioni, Sander van den Heuvel, Mike Boxem

Publikováno v: PLoS Genetics, Vol 17, Iss 10, p e1009856 (2021)

The conserved adapter protein Scribble (Scrib) plays essential roles in a variety of cellular processes, including polarity establishment, proliferation, and directed cell migration. While the mechanisms through which Scrib promotes epithelial polari

Externí odkaz: https://doaj.org/article/3b69aaafd7ad4814abf3a19a6e951825

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Akademický článek

Deep learning predictions of survival based on MRI in amyotrophic lateral sclerosis

Autor: Hannelore K. van der Burgh, Ruben Schmidt, Henk-Jan Westeneng, Marcel A. de Reus, Leonard H. van den Berg, Martijn P. van den Heuvel

Publikováno v: NeuroImage: Clinical, Vol 13, Iss C, Pp 361-369 (2017)

Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease, with large variation in survival between patients. Currently, it remains rather difficult to predict survival based on clinical parameters alone. Here, we set out to use clin

Externí odkaz: https://doaj.org/article/914548be30a7449da49ede61b553ef28

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Akademický článek

Optogenetic dissection of mitotic spindle positioning in vivo

Autor: Lars-Eric Fielmich, Ruben Schmidt, Daniel J Dickinson, Bob Goldstein, Anna Akhmanova, Sander van den Heuvel

Publikováno v: eLife, Vol 7 (2018)

The position of the mitotic spindle determines the plane of cell cleavage, and thereby daughter cell location, size, and content. Spindle positioning is driven by dynein-mediated pulling forces exerted on astral microtubules, which requires an evolut

Externí odkaz: https://doaj.org/article/8141aac012804ffa86243117121437c2

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Akademický článek

Multisite Phosphorylation of NuMA-Related LIN-5 Controls Mitotic Spindle Positioning in C. elegans.

Autor: Vincent Portegijs, Lars-Eric Fielmich, Matilde Galli, Ruben Schmidt, Javier Muñoz, Tim van Mourik, Anna Akhmanova, Albert J R Heck, Mike Boxem, Sander van den Heuvel

Publikováno v: PLoS Genetics, Vol 12, Iss 10, p e1006291 (2016)

During cell division, the mitotic spindle segregates replicated chromosomes to opposite poles of the cell, while the position of the spindle determines the plane of cleavage. Spindle positioning and chromosome segregation depend on pulling forces on

Externí odkaz: https://doaj.org/article/65b4e9471ec84fcebdab820d5774c799

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