Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Ruben R. Gonzalez-Perez"'
Publikováno v:
Medicines, Vol 5, Iss 3, p 68 (2018)
There is accumulating evidence that deregulated Notch signaling affects cancer development, and specifically pancreatic cancer (PC) progression. Notch canonical and non-canonical signaling has diverse impact on PC. Moreover, the actions of RBP-Jk (nu
Externí odkaz:
https://doaj.org/article/9ecda066f53e4a7c976fa3cb9a4b4bd7
Autor:
Ann Anu Kurian, Danielle Daley-Brown, Adriana Harbuzariu, Gabriela Oprea-Ilies, Ruben R. Gonzalez-Perez
Publikováno v:
World Journal of Clinical Oncology
BACKGROUND Obesity is a recognized risk factor for endometrial cancer (EmCa) and other cancer types. Leptin levels are significantly increased in obese individuals. Leptin-induced signaling crosstalk [Notch, Interleukin-1 (IL-1) and leptin outcome, N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578f0ba0da09e52cf9f1cf6595f5985e
https://doi.org/10.5306/wjco.v10.i6.222
https://doi.org/10.5306/wjco.v10.i6.222
Autor:
Robert W. Robey, Crystal C Lipsey, Lyn M. Huff, Michael M. Gottesman, Adriana Harbuzariu, Ruben R. Gonzalez-Perez
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3794, p 3794 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 11
International Journal of Molecular Sciences
Volume 21
Issue 11
Estrogen-receptor-negative breast cancer (BCER&minus
) is mainly treated with chemotherapeutics. Leptin signaling can influence BCER&minus
progression, but its effects on patient survival and chemoresistance are not well understood. We hypo
) is mainly treated with chemotherapeutics. Leptin signaling can influence BCER&minus
progression, but its effects on patient survival and chemoresistance are not well understood. We hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89ea2fe4ae8d65e548532598dbaf5dfd
https://www.mdpi.com/1422-0067/21/11/3794
https://www.mdpi.com/1422-0067/21/11/3794
Publikováno v:
Oncotarget
5-FU chemotherapy is a current strategy to treat pancreatic cancer (PC), but unfortunately chemoresistance is eventually developed in most patients. Obesity is a risk factor for PC that could affect 5-FU effectiveness through the adipokine leptin, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b5c3c9fa9836547567d5fd4233560d
https://doi.org/10.18632/oncotarget.24435
https://doi.org/10.18632/oncotarget.24435
Autor:
Elena Garonna, Kathleen M Botham, Graeme M Birdsey, Anna M Randi, Ruben R Gonzalez-Perez, Caroline P D Wheeler-Jones
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18823 (2011)
BACKGROUND:The adipocyte-derived hormone leptin influences the behaviour of a wide range of cell types and is now recognised as a pro-angiogenic and pro-inflammatory factor. In the vasculature, these effects are mediated in part through its direct le
Externí odkaz:
https://doaj.org/article/4ba8e8802eb4401a92ee4df79f5293b5
Autor:
Elena Garonna, Kathleen M. Botham, Graeme M. Birdsey, Anna M. Randi, Ruben R. Gonzalez-Perez, Caroline P. D. Wheeler-Jones
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 9, p e0223400 (2019)
PLoS ONE, Vol 14, Iss 9, p e0223400 (2019)
The adipocyte-derived hormone leptin influences the behaviour of a wide range of cell types and is now recognised as a pro-angiogenic and pro-inflammatory factor. In the vasculature, these effects are mediated in part through its direct leptin recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b73a5765221d1be4f469d39d568fa6e6
http://europepmc.org/articles/PMC6768471
http://europepmc.org/articles/PMC6768471
Autor:
Pierre V. Candelaria, Danielle Daley-Brown, Antonio Rampoldi, Tia L. Harmon, Alexander Quarshie, Ruben R. Gonzalez-Perez, Crystal C. Lipsey, Adriana Harbuzariu, Gabriela Oprea Ilies, Derrick J. Beech
Publikováno v:
Oncotarget
Pancreatic cancer (PC) shows a high death rate. PC incidence and prognosis are affected by obesity, a pandemic characterized by high levels of leptin. Notch is upregulated by leptin in breast cancer. Thus, leptin and Notch crosstalk could influence P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b9b214226eccf870a3b0ca2b77c10a
https://doi.org/10.18632/oncotarget.13946
https://doi.org/10.18632/oncotarget.13946
Publikováno v:
Advances in Pancreatic Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3259a7480669fb4c1a93eab5b128cdf2
https://doi.org/10.5772/intechopen.76400
https://doi.org/10.5772/intechopen.76400
Autor:
Roberto Carrio, Thais Agostini, Margot P. Cleary, Eduardo Lamas-Basulto, Marta Torroella-Kouri, Olivia Casas, Ana M. Santander, Lidia G. Sanchez, Omar Lopez-Ocejo, Ruben R. Gonzalez-Perez
Publikováno v:
Cancers, Vol 7, Iss 1, Pp 143-178 (2015)
Cancers
Volume 7
Issue 1
Pages 143-178
Cancers
Volume 7
Issue 1
Pages 143-178
The relationship between obesity and breast cancer (BC) has focused on serum factors. However, the mammary gland contains adipose tissue (AT) which may enable the crosstalk between adipocytes and tumor cells contributing to tumor macrophage recruitme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b2182dbeae0df8e24bc59a8c7107d5
https://doi.org/10.3390/cancers7010143
https://doi.org/10.3390/cancers7010143
Publikováno v:
Molecular and Cellular Endocrinology. 382:570-582
Despite accumulating evidence suggesting a positive correlation between leptin levels, obesity, post-menopause and breast cancer incidence, our current knowledge on the mechanisms involved in these relationships is still incomplete. Since the cloning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6107689ad59aa4b3317ee6b5c5fa1957
https://doi.org/10.1016/j.mce.2013.03.025
https://doi.org/10.1016/j.mce.2013.03.025