Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Ruben Papoian"'
Autor:
Huifang Hao, Yutaka Maeda, Takuya Fukazawa, Tomoki Yamatsuji, Munenori Takaoka, Xiao-Hong Bao, Junji Matsuoka, Tatsuo Okui, Tsuyoshi Shimo, Nagio Takigawa, Yasuko Tomono, Motowo Nakajima, Iris M Fink-Baldauf, Sandra Nelson, William Seibel, Ruben Papoian, Jeffrey A Whitsett, Yoshio Naomoto
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0307052 (2024)
[This corrects the article DOI: 10.1371/journal.pone.0071093.].
Externí odkaz:
https://doaj.org/article/aa0bc346399142da8c7d95143a75e94c
Autor:
Huifang Hao, Yutaka Maeda, Takuya Fukazawa, Tomoki Yamatsuji, Munenori Takaoka, Xiao-Hong Bao, Junji Matsuoka, Tatsuo Okui, Tsuyoshi Shimo, Nagio Takigawa, Yasuko Tomono, Motowo Nakajima, Iris M Fink-Baldauf, Sandra Nelson, William Seibel, Ruben Papoian, Jeffrey A Whitsett, Yoshio Naomoto
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71093 (2013)
Midkine (MDK) is a heparin-binding growth factor that is highly expressed in many malignant tumors, including lung cancers. MDK activates the PI3K pathway and induces anti-apoptotic activity, in turn enhancing the survival of tumors. Therefore, the i
Externí odkaz:
https://doaj.org/article/b75e1d242be6485ab7d452d9ecfd5c45
Autor:
Zhiqian Dong, William L. Seibel, Ruben Papoian, Sreenivasa R. Mundla, X. Eric Hu, Marcin Golczak, Krzysztof Palczewski, Jianye Zhang
Publikováno v:
Molecular Pharmacology. 87:477-491
All-trans-retinal, a retinoid metabolite naturally produced upon photoreceptor light activation, is cytotoxic when present at elevated levels in the retina. To lower its toxicity, two experimentally validated methods have been developed involving inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f28c300f460acc512ac243eff13f109
https://doi.org/10.1124/mol.114.096560
https://doi.org/10.1124/mol.114.096560
Autor:
William L. Seibel, Hong Tang, Philip D. Kiser, Yuanyuan Chen, Marcin Golczak, Jianye Zhang, Xiaoyu Li, Ki Oh, Ruben Papoian, Krzysztof Palczewski
Publikováno v:
Molecular Pharmacology. 86:231-242
Aspartyl aminopeptidase (DNPEP) has been implicated in the control of angiotensin signaling and endosome trafficking, but its precise biologic roles remain incompletely defined. We performed a high-throughput screen of ∼25,000 small molecules to id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a0fe1c8e9e19dce9ebe6019a7941d6
https://doi.org/10.1124/mol.114.093070
https://doi.org/10.1124/mol.114.093070
Autor:
Robert Bittman, Duane D. Miller, Sandra Nelson, Truc Chi T. Pham, Ryoko Tsukahara, R. Jason Kirby, Renukadevi Patil, Gabor Tigyi, Derek D. Norman, Daniel L. Baker, Abby L. Parrill, William L. Seibel, Sue Chin Lee, James I. Fells, Ruben Papoian
Publikováno v:
FEBS Journal. 281:1017-1028
Modulation of autotaxin (ATX), the lysophospholipase D enzyme that produces lysophosphatidic acid, with small-molecule inhibitors is a promising strategy for blocking the ATX-lysophosphatidic acid signaling axis. Although discovery campaigns have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1498b4ea97e862420a332c3d9332006d
https://doi.org/10.1111/febs.12674
https://doi.org/10.1111/febs.12674
Autor:
Jennifer N. Cash, Sandra Nelson, Ruben Papoian, R. Jason Kirby, William L. Seibel, Elizabeth B. Angerman, Lisa Merck, Matthew D. Wortman, Thomas B. Thompson
Publikováno v:
SLAS Discovery. 18:837-844
Myostatin, a member of the transforming growth factor (TGF)-β family of secreted ligands, is a strong negative regulator of muscle growth. As such, therapeutic inhibitors of myostatin are actively being investigated for their potential in the treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1c0e801450862b00074b0dd645d2aa
https://doi.org/10.1177/1087057113482585
https://doi.org/10.1177/1087057113482585
Publikováno v:
Trends in Endocrinology & Metabolism. 21:691-698
Breast and prostate cancers are hormone-sensitive malignancies that afflict millions of women and men. Although prolactin (PRL) is known as a survival factor that supports tumor growth and confers chemoresistance in both cancers, its precise role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aebc08f1ceb8300c35dbc1c84ad87d0
https://doi.org/10.1016/j.tem.2010.08.004
https://doi.org/10.1016/j.tem.2010.08.004
Publikováno v:
The Open Conference Proceedings Journal. 1:39-45
Breast cancer is both a common and a significant health concern for women across the globe. Emerging evidence suggests that the prolactin (PRL) signaling cascade contributes to the pathophysiology of breast cancer as well as to chemoresistance. The i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0860397c2cfc2cd040e0261a3b85c7cd
https://doi.org/10.2174/22102892010010100039
https://doi.org/10.2174/22102892010010100039
Autor:
Xun Shang, Chris R. Evelyn, Ruben Papoian, Sandra Nelson, Jacek Biesiada, Jaroslaw Meller, Hong Tang, Xin Duan, William L. Seibel, Yi Zheng
The Ras family small GTPases regulate multiple cellular processes, including cell growth, survival, movement, and gene expression, and are intimately involved in cancer pathogenesis. Activation of these small GTPases is catalyzed by a special class o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb66d65dfe9396646350537f5a3df29b
https://europepmc.org/articles/PMC4432303/
https://europepmc.org/articles/PMC4432303/
A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation
Autor:
Xiaoyu Li, Yuanyuan Chen, Krzysztof Palczewski, Ruben Papoian, Nevin A. Lambert, Hong Tang, William L. Seibel
Publikováno v:
Investigative ophthalmologyvisual science. 56(4)
Cell- and tissue culture–based high-throughput screening (HTS) represents a mainstream approach for drug discovery used either to identify biologically active small molecules or genes associated with a given phenotype in genome-wide loss-of-functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a20cfe23cffc47a3afe806c275896a3
https://pubmed.ncbi.nlm.nih.gov/25783607
https://pubmed.ncbi.nlm.nih.gov/25783607