Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ruben Isacson"'
Autor:
Mårten Fryknäs, Rolf Larsson, Stig Linder, Peter Nygren, Mats Gustafsson, Urban Höglund, Ruben Isacson, Maria Hägg Olofsson, Xiaonan Zhang, Wojciech Senkowski
Supplementary Figures S1-S8. S1. Glucose concentration and pH in spheroid culture medium; S2. Dose-response and time-course experiment; S3. GFP-based and TOX8 assay comparison; S4. HT-29 spheroid-based clonogenic assay; S5. Final hit compounds' effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9466d9ab091164d34eb62f48b0c001be
https://doi.org/10.1158/1535-7163.22501003
https://doi.org/10.1158/1535-7163.22501003
Autor:
Mårten Fryknäs, Rolf Larsson, Stig Linder, Peter Nygren, Mats Gustafsson, Urban Höglund, Ruben Isacson, Maria Hägg Olofsson, Xiaonan Zhang, Wojciech Senkowski
Supplementary materials, Tables S1-S2. Supplementary Table S1. List of the 12 3D-selective screening hits, Supplementary Table S2. Structures and properties of the five final hit compounds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40de9ecfce1f7bbce5f89799deb441e7
https://doi.org/10.1158/1535-7163.22501000.v1
https://doi.org/10.1158/1535-7163.22501000.v1
Autor:
Mårten Fryknäs, Rolf Larsson, Stig Linder, Peter Nygren, Mats Gustafsson, Urban Höglund, Ruben Isacson, Maria Hägg Olofsson, Xiaonan Zhang, Wojciech Senkowski
Because dormant cancer cells in hypoxic and nutrient-deprived regions of solid tumors provide a major obstacle to treatment, compounds targeting those cells might have clinical benefits. Here, we describe a high-throughput drug screening approach, us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::752cab2a6f186791e5009bb665a145bd
https://doi.org/10.1158/1535-7163.c.6536653.v1
https://doi.org/10.1158/1535-7163.c.6536653.v1
Autor:
Wojciech Senkowski, Xiaonan Zhang, Stig Linder, Ruben Isacson, Maria Hägg Olofsson, Mats G. Gustafsson, Rolf Larsson, Peter Nygren, Urban Höglund, Mårten Fryknäs
Because dormant cancer cells in hypoxic and nutrient-deprived regions of solid tumors provide a major obstacle to treatment, compounds targeting those cells might have clinical benefits. Here, we describe a high-throughput drug screening approach, us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97434bc8f9098535cecd9661e0c0804
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-120662
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-120662
Publikováno v:
Acta Physiologica Scandinavica. 179:173-177
The intrastriatal infusions of ‘naked’ small interfering RNA (siRNA) targeted to dopamine D1 receptors (1.0–10.0 nmol over 3 days) did not reduce dopamine D1 receptor messenger RNA levels or receptor protein, assessed by [125I] SCH 23982 bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::430ab6dcbe5def4c06067dad55d83889
https://doi.org/10.1046/j.1365-201x.2003.01188.x
https://doi.org/10.1046/j.1365-201x.2003.01188.x
Autor:
Karin Dannaeus, Harriet Rönnholm, Theo Palmer, Ming Zhao, Olof Zachrisson, Anders Haegerstrand, Ann Marie Janson Lang, Cesare Patrone, Lilian Wikstrom, Elisabet Nielsen, Annica Andersson, Michael P. Hill, Kristofer Delfani, Johan Haggblad, Ruben Isacson, Alison L. McCormack, Donato A. Di Monte
Publikováno v:
Journal of Parkinson's disease. 1(1)
Parkinson's disease is characterized by motor deficits caused by loss of midbrain dopaminergic neurons. Neurotrophic factors and cell transplantation have partially restored function in models of Parkinson's disease, but have had limited effects in h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8d5b4a98c256a7185577d08ffbfd3c
https://pubmed.ncbi.nlm.nih.gov/23939256
https://pubmed.ncbi.nlm.nih.gov/23939256
Autor:
Karin Dannaeus, Lilian Wikstrom, Göran Bertilsson, Ruben Isacson, Cesare Patrone, Elisabet Nielsen, Olof Zachrisson
Publikováno v:
European journal of pharmacology. 650(1)
We have earlier shown that the glucagon-like peptide 1 receptor agonist exendin-4 stimulates neurogenesis in the subventricular zone and excerts anti-parkinsonian behavior. The aim of this study was to assess the effects of exendin-4 treatment on hip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e7203fd45cdf4871fb57b08a538c10
https://pubmed.ncbi.nlm.nih.gov/20951130
https://pubmed.ncbi.nlm.nih.gov/20951130
The functional role of dopamine D(1) receptors is still controversial. One reason for this controversy is that for a long time the only available agonists for in vivo characterization of dopamine D(1) receptors were benzazepines. Among them was the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad825fef6bbc2263d9d44366c3f73b26
https://europepmc.org/articles/PMC6741759/
https://europepmc.org/articles/PMC6741759/
Publikováno v:
Neuroscience. 124(1)
The behavioral and biochemical effects of the full dopamine D(1/5) receptor agonists, dihydrexidine and (1R,3S)-1-aminomethyl-5,6-dihydroxy-3-phenylisochroman HCl (A 68930), were examined in rats. Both A 68930 (0-4.6 mg kg(-1), s.c.) and dihydrexidin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a513a056ca68cc34ef3a49d6f8301f0d
https://pubmed.ncbi.nlm.nih.gov/14960337
https://pubmed.ncbi.nlm.nih.gov/14960337
Publikováno v:
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 13(3)
The present study investigated potential anti-cataleptic properties of the prototype atypical antipsychotic clozapine and two newly developed atypical antipsychotics, olanzapine and quetiapine, which are structurally related and display similar pharm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e9ac35767518e8305b1eb42e8c6679
https://pubmed.ncbi.nlm.nih.gov/12729943
https://pubmed.ncbi.nlm.nih.gov/12729943