The Polycomb Group Protein L3MBTL1 Represses a SMAD5-Mediated Hematopoietic Transcriptional Program in Human Pluripotent Stem Cells

Autor: Fabiana Perna, Ly P. Vu, Maria Themeli, Sonja Kriks, Ruben Hoya-Arias, Raya Khanin, Todd Hricik, Jorge Mansilla-Soto, Eirini P. Papapetrou, Ross L. Levine, Lorenz Studer, Michel Sadelain, Stephen D. Nimer

Publikováno v: Stem Cell Reports, Vol 4, Iss 4, Pp 658-669 (2015)

Epigenetic regulation of key transcriptional programs is a critical mechanism that controls hematopoietic development, and, thus, aberrant expression patterns or mutations in epigenetic regulators occur frequently in hematologic malignancies. We demo

Externí odkaz: https://doaj.org/article/063ec1c46d1b41b4ac0026122cb9bb13

L3MBTL1 Deficiency Directs the Differentiation of Human Embryonic Stem Cells Toward Trophectoderm

Autor: Stephen D. Nimer, Francesca Voza, Ruben Hoya-Arias, Fabiana Perna, Mark J. Tomishima

Publikováno v: Stem Cells and Development. 20:1889-1900

Human embryonic stem cells (hESCs) can be used to study the early events in human development and, hopefully, to understand how to differentiate human pluripotent cells for clinical use. To define how L3MBTL1, a chromatin-associated polycomb group pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f89f68de6d34c2f54fe459cf5ecc48
https://doi.org/10.1089/scd.2010.0437

The polycomb group protein L3MBTL1 represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells

Autor: Ross L. Levine, Ly P. Vu, Fabiana Perna, Stephen D. Nimer, Eirini P. Papapetrou, Lorenz Studer, Sonja Kriks, Michel Sadelain, Ruben Hoya-Arias, Todd Hricik, Jorge Mansilla-Soto, Raya Khanin, Maria Themeli

Publikováno v: Stem Cell Reports
Stem Cell Reports, Vol 4, Iss 4, Pp 658-669 (2015)
Stem Cell Reports, 4(4), 658-669. Cell Press
Perna, F, Vu, L P, Themeli, M, Kriks, S, Hoya-Arias, R, Khanin, R, Hricik, T, Mansilla-Soto, J, Papapetrou, E P, Levine, R L, Studer, L, Sadelain, M & Nimer, S D 2015, ' The polycomb group protein L3MBTL1 repreßes a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells ', Stem Cell Reports, vol. 4, no. 4, pp. 658-669 . https://doi.org/10.1016/j.stemcr.2015.02.003

Summary Epigenetic regulation of key transcriptional programs is a critical mechanism that controls hematopoietic development, and, thus, aberrant expression patterns or mutations in epigenetic regulators occur frequently in hematologic malignancies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53343d6ffa7ccb451ccb107661e92320
https://pubmed.ncbi.nlm.nih.gov/25754204

Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation

Autor: Geertrui Denecker, Ali A. Bahar, Wim Declercq, Michael Devos, Sam Lievens, Marc Bracke, Dorien Clarisse, Valerie Gossye, Wim Vanden Berghe, Guy Haegeman, Nadia Bougarne, Sofie Desmet, Kris Gevaert, Jan Tavernier, Bart Ruttens, Zuzanna Drebert, Ruben Hoya-Arias, Ilse M. Beck, Karolien De Bosscher

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 7, p e69115 (2013)
PLOS ONE

Compound A possesses glucocorticoid receptor (GR)-dependent anti-inflammatory properties. Just like classical GR ligands, Compound A can repress NF-kappa B-mediated gene expression. However, the monomeric Compound A-activated GR is unable to trigger

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b848b6c9274a62d47aaaf9358cab3b75
https://hdl.handle.net/10067/1107620151162165141

Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1

Autor: Piernicola Boccuni, Xinyang Zhao, Nadia Gurvich, Donal MacGrogan, Stephen D. Nimer, Nagesh Kalakonda, J C Rice, Y Miyata, Wolfgang Fischle, J Zhang, Ruben Hoya-Arias, Jennifer K. Sims

Publikováno v: Oncogene. 27(31)

Lethal 3 malignant brain tumor 1 (L3MBTL1), a homolog of the Drosophila polycomb tumor suppressor l(3)mbt, contains three tandem MBT repeats (3xMBT) that are critical for transcriptional repression. We recently reported that the 3xMBT repeats interac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400f658a4682e811e9c7842a0793c4cd
https://pubmed.ncbi.nlm.nih.gov/18408754