The Contribution of Homocysteine Metabolism Disruption to Endothelial Dysfunction: State-of-the-Art

Autor: Ruben Esse, Madalena Barroso, Isabel Tavares de Almeida, Rita Castro

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 4, p 867 (2019)

Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid formed during the metabolism of the essential amino acid methionine. Hcy is considered a risk factor for atherosclerosis and cardiovascular disease (CVD), but the molecular basis

Externí odkaz: https://doaj.org/article/fd19d69c380549519e468cb64f3b6995

Protein arginine methylation is more prone to inhibition by S-adenosylhomocysteine than DNA methylation in vascular endothelial cells.

Autor: Ruben Esse, Monica S Rocha, Madalena Barroso, Cristina Florindo, Tom Teerlink, Robert M Kok, Yvo M Smulders, Isabel Rivera, Paula Leandro, Pieter Koolwijk, Rita Castro, Henk J Blom, Isabel Tavares de Almeida

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e55483 (2013)

Methyltransferases use S-adenosylmethionine (AdoMet) as methyl group donor, forming S-adenosylhomocysteine (AdoHcy) and methylated substrates, including DNA and proteins. AdoHcy inhibits most methyltransferases. Accumulation of intracellular AdoHcy s

Externí odkaz: https://doaj.org/article/841a09fd4f574ec8993de1f3fe8d9e03

Genomic imprinting and maternal adaptations to pregnancy

Autor: Marika Charalambous, Valeria Scagliotti, Ruben Esse, Risha Amarsi, Vignola Maria Lillina

Publikováno v: Endocrine Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81d9b2551330bc0d71a70cacd2e58b39
https://doi.org/10.1530/endoabs.86.p361

Caenorhabditis elegans Deficient in DOT-1.1 Exhibit Increases in H3K9me2 at Enhancer and Certain RNAi-Regulated Regions

Autor: Alla Grishok, Ruben Esse

Publikováno v: Cells, Vol 9, Iss 1846, p 1846 (2020)
Cells
Volume 9
Issue 8

The methylation of histone H3 at lysine 79 is a feature of open chromatin. It is deposited by the conserved histone methyltransferase DOT1. Recently, DOT1 localization and H3K79 methylation (H3K79me) have been correlated with enhancers in C. elegans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d45bcb27229615e57afbc9ef6331adc
https://doi.org/10.3390/cells9081846

Folinic acid increases protein arginine methylation in human endothelial cells

Autor: Pieter Koolwijk, Ruben Esse, Tom Teerlink, Rita Castro, Isabel Tavares de Almeida, Henk J. Blom

Publikováno v: Nutrients, 10(4):404. Multidisciplinary Digital Publishing Institute (MDPI)
Esse, R, Teerlink, T, Koolwijk, P, Tavares de Almeida, I, Blom, H J & Castro, R 2018, ' Folinic acid increases protein arginine methylation in human endothelial cells ', Nutrients, vol. 10, no. 4, 404 . https://doi.org/10.3390/nu10040404
Nutrients
Nutrients; Volume 10; Issue 4; Pages: 404
Nutrients, Vol 10, Iss 4, p 404 (2018)

Elevated plasma total homocysteine (tHcy) is associated with increased risk of cardiovascular disease, but the mechanisms underlying this association are not completely understood. Cellular hypomethylation has been suggested to be a key pathophysiolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbde419b2c5049ee859376b9f14990b4
https://research.vumc.nl/en/publications/5292a1f2-2740-4933-97fe-e57b9d89538f