Human AdV-20-42-42, a promising novel adenoviral vector for gene therapy and vaccine product development

Autor: Patrick W. F. Hadoke, Hilde M. van der Schaar, Mónika Z. Ballmann, Lars Frängsmyr, Satish Boedhoe, Győző L. Kaján, Niklas Arnberg, Abdelaziz Beqqali, Angelique A. C. Lemckert, Svjetlana Raus, Tibor Papp, Lijo John, Andrew H. Baker, Ruben Engelhart, Jerome Custers, Selina Khan, Chantal van der Zalm, Wilfried A.M. Bakker, Katarina Danskog, Menzo J. E. Havenga

Publikováno v: Journal of Virology
Ballmann, M Z, Raus, S, Engelhart, R, Kaján, G L, Beqqali, A, Hadoke, P W, Van Der Zalm, C, Papp, T, John, L, Khan, S, Boedhoe, S, Danskog, K, Frängsmyr, L, Custers, J, Bakker, W A M, Van Der Schaar, H M, Arnberg, N, Lemckert, A A C, Havenga, M & Baker, A H 2021, ' Human AdV-20-42-42, a promising novel adenoviral vector for gene therapy and vaccine product development ', Journal of Virology . https://doi.org/10.1128/JVI.00387-21

Preexisting immune responses toward adenoviral vectors limit the use of a vector based on particular serotypes and its clinical applicability for gene therapy and/or vaccination. Therefore, there is a significant interest in vectorizing novel adenovi

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