Zobrazeno 1 - 10
of 454
pro vyhledávání: '"Ruben Abagyan"'
Autor:
Brenton P. Munson, Michael Chen, Audrey Bogosian, Jason F. Kreisberg, Katherine Licon, Ruben Abagyan, Brent M. Kuenzi, Trey Ideker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Polypharmacology drugs—compounds that inhibit multiple proteins—have many applications but are difficult to design. To address this challenge we have developed POLYGON, an approach to polypharmacology based on generative reinforcement le
Externí odkaz:
https://doaj.org/article/55b169129e9145c5abf476bbec8ac7f5
Autor:
Tigran Makunts, Ruben Abagyan
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
3,4-Methylenedioxymethamphetamine (MDMA) is being investigated in controlled clinical trials for use as an adjunct medication treatment for post-traumatic stress disorder. MDMA is metabolized by N-demethylation, primarily by CYP2D6, to its main inact
Externí odkaz:
https://doaj.org/article/d63850a0cdca4e8db7b4e5d8d7fe4361
Publikováno v:
JMIRx Med, Vol 5, Pp e55976-e55976 (2024)
Abstract BackgroundGlucagon-like peptide-1 (GLP-1) receptor agonists (RAs) are one of the most commonly used drugs for type 2 diabetes mellitus. Clinical guidelines recommend GLP-1 RAs as an adjunct to diabetes therapy in patients with chronic kidne
Externí odkaz:
https://doaj.org/article/d16281af39c74487a370da31b05ad63f
Publikováno v:
JMIRx Med, Vol 5, Pp e58273-e58273 (2024)
Externí odkaz:
https://doaj.org/article/bf6df77328f041d8aad6243b242a8d04
Publikováno v:
Pharmacoepidemiology, Vol 2, Iss 3, Pp 272-282 (2023)
Proton-pump inhibitors, PPIs, are widely prescribed and are available over the counter for prolonged reduction of stomach acid production and related disorders. PPIs irreversibly inhibit the hydrogen/potassium ATPase in gastric parietal cells. Recent
Externí odkaz:
https://doaj.org/article/a0c3b89a05184c309f3e046af9d2268b
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Rheumatoid arthritis, RA, is a chronic autoimmune disease characterized by joint pain, tenderness, swelling, and stiffness. This disease affects nearly 1% of the world population. RA predominates in females and typically develops between the
Externí odkaz:
https://doaj.org/article/91f6ab19a7e3417e963945c46f129575
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
3,4-Methylenedioxymethamphetamine (MDMA) is currently being investigated as an adjunctive treatment to therapy for posttraumatic stress and other anxiety related disorders in clinical trials. Within the next few years MDMA-assisted therapy is project
Externí odkaz:
https://doaj.org/article/91692d656f5a46a3ba35f4ec0194d9fe
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Osteoporosis affects over 10 million Americans over 50. Bisphosphonate therapy, mainly alendronate, is amongst the most prescribed treatments for the disease. The use of alendronate and other bisphosphonates has been associated with depressi
Externí odkaz:
https://doaj.org/article/3a0f2bd629644aef8fb8c38b036794c0
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Randomized controlled trials (RCTs) have shown an antidepressant effect of glabellar botulinum toxin (BoNT) injections. In the FDA Adverse Event Reporting System (FAERS) database, BoNT injection is associated with reduced incidence rates of
Externí odkaz:
https://doaj.org/article/929c0971c2234a46a2163e2802818440
Autor:
Tigran Makunts, Ila M. Saunders, Isaac V. Cohen, Mengxing Li, Talar Moumedjian, Masara A. Issa, Keith Burkhart, Peter Lee, Sandip Pravin Patel, Ruben Abagyan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Antibodies targeting the PD-1, PD-L1, and CTLA-4 immune checkpoint axis have been used in a variety of tumor types. They achieve anti-tumor activity through activating the patient’s own immune system to target immune response evading cance
Externí odkaz:
https://doaj.org/article/f9e5c40ece6d4172afc9cd95cfa7fd22