Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Ruben, Bill"'
Autor:
Alfred Zippelius, Mélanie Buchi, Richard Klar, Julia Festag, Sven Michel, Frank Jaschinski, Sebastian Kobold, Abhishek S Kashyap, Johannes vom Berg, Laura Fernandez-Rodriguez, Chiara Cianciaruso, Ruben Bill, Marcel P Trefny, Nicole Kirchhammer, Rainer H Kohler, Elham Jones, Andre Maaske, Karen O Dixon, Mikael J Pittet
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
Background Although immune checkpoint inhibitors have been a breakthrough in clinical oncology, these therapies fail to produce durable responses in a significant fraction of patients. This lack of long-term efficacy may be due to a poor pre-existing
Externí odkaz:
https://doaj.org/article/78cf6c8515374d7f847b8913a986bde6
Autor:
Ruben Bill, Daniel G. Deschler, Mikael J. Pittet, Sara I. Pai, Peter M. Sadow, Jong Chul Park
Publikováno v:
Cancer Reports, Vol 5, Iss 3, Pp n/a-n/a (2022)
Abstract Background Secretory carcinoma is a more recently described subtype of salivary gland carcinoma that may pose diagnostic challenges and frequently harbors NTRK fusions that may successfully be targeted by TRK inhibitors in advanced disease.
Externí odkaz:
https://doaj.org/article/3502dd3b3d334ee6b7ccb156233cf336
Autor:
Mikael J. Pittet, Allon M. Klein, Ralph Weissleder, Virginia Savova, Rainer H. Kohler, Maaz S. Ahmed, Jeremy Quintana, Michael F. Cuccarese, Christopher B. Rodell, Angela N. Marquard, Melissa M. Sprachman, Jeremy Gungabeesoon, Marie Siwicki, Ruben Bill, Yunkang Lin, Nicolas A. Gort-Freitas, Steffen Rickelt, Angela E. Zou, Marius Messemaker, Camilla Engblom, Rapolas Zilionis, Christina Pfirschke
Supplementary Data from Macrophage-Targeted Therapy Unlocks Antitumoral Cross-talk between IFNγ-Secreting Lymphocytes and IL12-Producing Dendritic Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03be49f542113058bc6ec50af244fe65
https://doi.org/10.1158/2326-6066.22544211
https://doi.org/10.1158/2326-6066.22544211
Autor:
Mikael J. Pittet, Allon M. Klein, Ralph Weissleder, Virginia Savova, Rainer H. Kohler, Maaz S. Ahmed, Jeremy Quintana, Michael F. Cuccarese, Christopher B. Rodell, Angela N. Marquard, Melissa M. Sprachman, Jeremy Gungabeesoon, Marie Siwicki, Ruben Bill, Yunkang Lin, Nicolas A. Gort-Freitas, Steffen Rickelt, Angela E. Zou, Marius Messemaker, Camilla Engblom, Rapolas Zilionis, Christina Pfirschke
Macrophages often abound within tumors, express colony-stimulating factor 1 receptor (CSF1R), and are linked to adverse patient survival. Drugs blocking CSF1R signaling have been used to suppress tumor-promoting macrophage responses; however, their m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dbe5dea6561f080330bae8bd2e02da5
https://doi.org/10.1158/2326-6066.c.6550572.v1
https://doi.org/10.1158/2326-6066.c.6550572.v1
Autor:
Aurel Perren, Ilaria Marinoni, Mario P. Tschan, Philippe Krebs, Ruben Bill, Lea Normand, Sophia Pantasis, Annika Blank, Tabea Wiedmer
Downregulation of autophagic flux in knockdown cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a389e4e9b066c8e35d83105878816db
https://doi.org/10.1158/1535-7163.22507801.v1
https://doi.org/10.1158/1535-7163.22507801.v1
Autor:
Aurel Perren, Ilaria Marinoni, Mario P. Tschan, Philippe Krebs, Ruben Bill, Lea Normand, Sophia Pantasis, Annika Blank, Tabea Wiedmer
Increasing the efficacy of approved systemic treatments in metastasized pancreatic neuroendocrine tumors (PanNET) is an unmet medical need. The antiangiogenic tyrosine kinase inhibitor sunitinib is approved for PanNET treatment. In addition, sunitini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63fac2d7a4489dc4a4a6599fd65882a3
https://doi.org/10.1158/1535-7163.c.6538795
https://doi.org/10.1158/1535-7163.c.6538795
Autor:
Laura Pisarsky, Ruben Bill, Ernesta Fagiani, Sarah Dimeloe, Ryan William Goosen, Jörg Hagmann, Christoph Hess, Gerhard Christofori
Publikováno v:
Cell Reports, Vol 15, Iss 6, Pp 1161-1174 (2016)
Despite the approval of several anti-angiogenic therapies, clinical results remain unsatisfactory, and transient benefits are followed by rapid tumor recurrence. Here, we demonstrate potent anti-angiogenic efficacy of the multi-kinase inhibitors nint
Externí odkaz:
https://doaj.org/article/2e1f3cdad32948ae82dae8837ddcdd50
Autor:
Gerhard Christofori, Frank Hilberg, Imke Albrecht, Simon Haefliger, David Johansson, Helena Antoniadis, Adrian Zumsteg, Ernesta Fagiani, Ruben Bill
Supplementary methods and Figures S1-S7. Supplementary Methods. Detailed description of reagents and protocols used for immunohistochemical and metastasis analysis, and immunofluorescence microscopy analysis. Supplementary Figure S1. Histopathologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44169c27d86f9648f529a3bb750d5575
https://doi.org/10.1158/1078-0432.22458375.v1
https://doi.org/10.1158/1078-0432.22458375.v1
Autor:
Gerhard Christofori, Frank Hilberg, Imke Albrecht, Simon Haefliger, David Johansson, Helena Antoniadis, Adrian Zumsteg, Ernesta Fagiani, Ruben Bill
Purpose: Pancreatic neuroendocrine tumors (PNET) represent a rare but challenging heterogeneous group of cancers with an increasing incidence over the last number of decades. Herein, we report an in-depth evaluation of the new antiangiogenic small-mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a26f4ce08a9b96ebf85d0a6d4c40bd5
https://doi.org/10.1158/1078-0432.c.6523929
https://doi.org/10.1158/1078-0432.c.6523929
Autor:
Chen Wang, Coline Barnoud, Mara Cenerenti, Mengzhu Sun, Irene Caffa, Burak Kizil, Ruben Bill, Yuanlong Liu, Robert Pick, Laure Garnier, Olga A. Gkountidi, Louise M. Ince, Stephan Holtkamp, Nadine Fournier, Olivier Michielin, Daniel E. Speiser, Stéphanie Hugues, Alessio Nencioni, Mikaël J. Pittet, Camilla Jandus, Christoph Scheiermann
Publikováno v:
Wang, Chen; Barnoud, Coline; Cenerenti, Mara; Sun, Mengzhu; Caffa, Irene; Kizil, Burak; Bill, Ruben; Liu, Yuanlong; Pick, Robert; Garnier, Laure; Gkountidi, Olga A; Ince, Louise M; Holtkamp, Stephan; Fournier, Nadine; Michielin, Olivier; Speiser, Daniel E; Hugues, Stéphanie; Nencioni, Alessio; Pittet, Mikaël J; Jandus, Camilla; ... (2023). Dendritic cells direct circadian anti-tumor immune responses. Nature, 614(7946), pp. 136-143. Springer Nature 10.1038/s41586-022-05605-0
The process of cancer immunosurveillance is a mechanism of tumour suppression that can protect the host from cancer development throughout its lifetime1,2. However, it is unknown whether the effectiveness of cancer immunosurveillance fluctuates over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153c5412fe0197711ec212feccd733e4
https://boris.unibe.ch/176997/1/s41586-022-05605-0_reference.pdf
https://boris.unibe.ch/176997/1/s41586-022-05605-0_reference.pdf