S184: SAFETY AND OUTCOMES FOLLOWING IMMUNOSUPPRESSIVE THERAPY WITH ATG/CYCLOSPORIN +/- ELTROMBOPAG FOR OLDER PATIENTS WITH SEVERE APLASTIC ANEMIA

Autor: Ashvind Prabahran, Jibran Durrani, Juan Coelho Da Silva, Ruba Shalhoub, Jennifer Lotter, Olga Rios, Colin Wu, Bhavisha Patel, Young Neal, Emma Groarke

Publikováno v: HemaSphere, Vol 7, p e8904593 (2023)

Externí odkaz: https://doaj.org/article/f0bb7f0475df46038579dd69b0e38c52

Eltrombopag monotherapy can improve hematopoiesis in patients with low to intermediate risk-1 myelodysplastic syndrome

Autor: Alana Vicente, Bhavisha A. Patel, Fernanda Gutierrez-Rodrigues, Emma Groarke, Valentina Giudice, Jennifer Lotter, Xingmin Feng, Sachiko Kajigaya, Barbara Weinstein, Evette Barranta, Matthew J. Olnes, Ankur R. Parikh, Maher Albitar, Colin O. Wu, Ruba Shalhoub, Katherine R. Calvo, Danielle M. Townsley, Phillip Scheinberg, Cynthia E. Dunbar, Neal S. Young, Thomas Winkler

Publikováno v: Haematologica, Vol 105, Iss 12 (2020)

Myelodysplastic syndromes (MDS) are a group of clonal myeloid disorders characterized by cytopenia and a propensity to develop acute myeloid leukemia (AML). The management of lower-risk (LR) MDS with persistent cytopenias remains suboptimal. Eltrombo

Externí odkaz: https://doaj.org/article/d39465a6ea80433faa1359329e4d1aed

Clonal hematopoiesis is not significantly associated with COVID-19 disease severity

Autor: Yifan Zhou, Ruba Shalhoub, Stephanie N. Rogers, Shiqin Yu, Muxin Gu, Margarete A. Fabre, Pedro M. Quiros, Tae-Hoon Shin, Arch Diangson, Wenhan Deng, Shubha Anand, Wenhua Lu, Matthew Cullen, Anna L. Godfrey, Jacobus Preller, Jerome Hadjadj, Emmanuelle Jouanguy, Aurélie Cobat, Laurent Abel, Frederic Rieux-Laucat, Benjamin Terrier, Alain Fischer, Lara Novik, Ingelise J. Gordon, Larisa Strom, Martin R. Gaudinski, Andrea Lisco, Irini Sereti, Thomas J. Gniadek, Andrea Biondi, Paolo Bonfanti, Luisa Imberti, Clifton L. Dalgard, Yu Zhang, Kerry Dobbs, Helen C. Su, Luigi D. Notarangelo, Colin O. Wu, Peter J.M. Openshaw, Malcolm G. Semple, Ziad Mallat, Kenneth Baillie, Cynthia E. Dunbar, George S. Vassiliou

Publikováno v: Zhou, Y, Shalhoub, R N, Rogers, S N, Yu, S, Gu, M, Fabre, M A, Quiros, P M, Diangson, A, Deng, W, Anand, S, Lu, W, Cullen, M, Godfrey, A L, Preller, J, Hadjadj, J, Jouanguy, E, Cobat, A, Abel, L, Rieux-Laucat, F, Terrier, B, Fischer, A, Novik, L, Gordon, I J, Strom, L, Gaudinski, M, Lisco, A, Sereti, I, Gniadek, T J, Biondi, A, Bonfanti, P, Imberti, L, Zhang, Y, Dalgard, C L, Dobbs, K, Su, H C, Notarangelo, L D, Wu, C O, Openshaw, P J M, Semple, M G, Mallat, Z, Baillie, K, Dunbar, C E & Vassiliou, G S 2022, ' Clonal Hematopoiesis Is Not Significantly Associated with Covid-19 Disease Severity ', Blood, vol. 140, no. 14, pp. 1650-1655 . https://doi.org/10.1182/blood.2022015721

Clonal hematopoiesis (CH) describes the disproportionate expansion of a hematopoietic stemcell (HSC) and its progeny, in association with leukemia-associated somatic mutations, mostcommonly affecting the genes for epigenetic regulators DNMT3A, TET2 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b76ab2376652b898353a85bd024178
https://www.repository.cam.ac.uk/handle/1810/340199

Predicting response of severe aplastic anemia to immunosuppression combined with eltrombopag

Autor: Emma M. Groarke, Bhavisha A Patel, Colin O. Wu, Xingmin Feng, Ruba Shalhoub, Neal S. Young, Yoshitaka Zaimoku

Publikováno v: Haematologica. 107:126-133

Pretreatment blood counts, particularly an absolute reticulocyte count ≥25×109/L, correlate with response to immunosuppressive therapy in severe aplastic anemia. In recent trials, eltrombopag combined with standard immunosuppressive therapy yielde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c31aae2e792e16836b54fb63fb4125d
https://doi.org/10.3324/haematol.2021.278413

Granulocyte Transfusions As an Adjunctive Therapy in Severe Aplastic Anemia

Autor: Roma V. Rajput, Vaani Shah, Ruba Shalhoub, Kamille West-Mitchell, Cathy Conry-Cantilena, David J. Young, Cynthia E. Dunbar, Bhavisha A. Patel, Richard W. Childs, Neal S. Young, Colin O. Wu, Emma M. Groarke, Shelley S. Kalsi

Publikováno v: Blood. 140:8556-8557

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02c74491df8751dc6995cf5a9171c614
https://doi.org/10.1182/blood-2022-162595