Single-nucleus chromatin accessibility reveals intratumoral epigenetic heterogeneity in IDH1 mutant gliomas

Autor: Ruslan Al-Ali, Katharina Bauer, Jong-Whi Park, Ruba Al Abdulla, Valentina Fermi, Andreas von Deimling, Christel Herold-Mende, Jan-Philipp Mallm, Carl Herrmann, Wolfgang Wick, Şevin Turcan

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-12 (2019)

Abstract The presence of genome-wide DNA hypermethylation is a hallmark of lower grade gliomas (LGG) with isocitrate dehydrogenase (IDH) mutations. Further molecular classification of IDH mutant gliomas is defined by the presence (IDHmut-codel) or ab

Externí odkaz: https://doaj.org/article/648525fc70e5488fb89fa53efcf3aa6f

Exploring the Effects of Metabolism-Disrupting Chemicals on Pancreatic α-Cell Viability, Gene Expression and Function: A Screening Testing Approach

Autor: Ruba Al-Abdulla, Hilda Ferrero, Talía Boronat-Belda, Sergi Soriano, Iván Quesada, Paloma Alonso-Magdalena

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 2; Pages: 1044

Humans are constantly exposed to many environmental pollutants, some of which have been largely acknowledged as key factors in the development of metabolic disorders such as diabetes and obesity. These chemicals have been classified as endocrine-disr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02fa5cc9aebde922844ff2bfcf143c7c

Causes of hOCT1‐Dependent Cholangiocarcinoma Resistance to Sorafenib and Sensitization by Tumor‐Selective Gene Therapy

Autor: Jesper B. Andersen, María L. Martínez-Chantar, Matías A. Avila, Ruba Al-Abdulla, Laura Sanchez-Vicente, Colm J O'Rourke, Letizia Satriano, Rocio I.R. Macias, Maria J. Monte, Elisa Lozano, Sofía Del Carmen, Maitane Asensio, Jose J.G. Marin, Jesus M. Banales, Oscar Briz, Patricia Munoz-Garrido, Marta Alonso-Peña

Publikováno v: Hepatology. 70:1246-1261

Although the multi-tyrosine kinase inhibitor sorafenib is useful in the treatment of several cancers, cholangiocarcinoma (CCA) is refractory to this drug. Among other mechanisms of chemoresistance, impaired uptake through human organic cation transpo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c745e2a1c2d845892285d5c5bb8dc85a
https://doi.org/10.1002/hep.30656

Screening of Relevant Metabolism-Disrupting Chemicals on Pancreatic β-Cells: Evaluation of Murine and Human In Vitro Models

Autor: Hilda Ferrero, Sergi Soriano, Ruba Al-Abdulla, PALOMA ALONSO MAGDALENA, Talía Boronat-Belda

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 8; Pages: 4182
RUA. Repositorio Institucional de la Universidad de Alicante
Universidad de Alicante (UA)

Endocrine-disrupting chemicals (EDCs) are chemical substances that can interfere with the normal function of the endocrine system. EDCs are ubiquitous and can be found in a variety of consumer products such as food packaging materials, personal care

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::880541d34ec6c3666646fa3d1d4e234f
https://doi.org/10.3390/ijms23084182

Relationship between changes in the exon-recognition machinery and SLC22A1 alternative splicing in hepatocellular carcinoma

Autor: Loreto Boix, Maria Reviejo, Jose J.G. Marin, Meraris Soto, Maria A. Serrano, Jordi Bruix, Ruba Al-Abdulla, Rocio I.R. Macias, Marta R. Romero

Publikováno v: Biochimica et biophysica acta. Molecular basis of disease. 1866(5)

Changes in the phenotype that characterizes cancer cells are partly due to altered processing of pre-mRNA by the spliceosome. We have previously reported that aberrant splicing plays an essential role in the impaired response of hepatocellular carcin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7e160d57b7c388f16f935628d20479
https://pubmed.ncbi.nlm.nih.gov/31953214