Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Rubén Varela"'
Autor:
Uxía Regueiro, Maite López-López, Rubén Varela-Fernández, Francisco Javier Otero-Espinar, Isabel Lema
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 865 (2023)
Lactoferrin (LF) is a first-line defense protein with a pleiotropic functional pattern that includes anti-inflammatory, immunomodulatory, antiviral, antibacterial, and antitumoral properties. Remarkably, this iron-binding glycoprotein promotes iron r
Externí odkaz:
https://doaj.org/article/c2426c96ffed42d488ba4a921fd0d17f
Publikováno v:
Journal of Marine Science and Engineering, Vol 10, Iss 12, p 1970 (2022)
Knowing future changes in the sea surface temperature (SST) is of vital importance since they can affect marine ecosystems, especially in areas of high productivity such as the Eastern Boundary Upwelling Systems (EBUS). In this sense, it is key to ha
Externí odkaz:
https://doaj.org/article/3dc7972343de42b88232cb819bd6bc81
Autor:
Victoria Díaz-Tomé, Carlos Bendicho-Lavilla, Xurxo García-Otero, Rubén Varela-Fernández, Manuel Martín-Pastor, José Llovo-Taboada, Pilar Alonso-Alonso, Pablo Aguiar, Miguel González-Barcia, Anxo Fernández-Ferreiro, Francisco J. Otero-Espinar
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 35 (2022)
Fungal keratitis (FK) is a corneal mycotic infection that can lead to vision loss. Furthermore, the severity of FK is aggravated by the emergence of resistant fungal species. There is currently only one FDA-approved formulation for FK treatment forci
Externí odkaz:
https://doaj.org/article/a898f5d66c8d4ee5aadfc9c9c1080480
Autor:
Uxía Regueiro, Maite López-López, Rubén Varela-Fernández, Tomás Sobrino, Elio Diez-Feijoo, Isabel Lema
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12350 (2022)
Keratoconus (KC) is a corneal disorder whose etiology shares a close relationship with Lactoferrin (LTF) dysregulation and Toll-like Receptors 2 (TLR2) overexpression. This study shows how these two important biomarkers are clinically and molecularly
Externí odkaz:
https://doaj.org/article/5836adf6e2674b5db9249895a09f4f44
Autor:
Mahwash Mukhtar, Noemi Csaba, Sandra Robla, Rubén Varela-Calviño, Attila Nagy, Katalin Burian, Dávid Kókai, Rita Ambrus
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1543 (2022)
Marketed dosage forms fail to deliver anti-tubercular drugs directly to the lungs in pulmonary Tuberculosis (TB). Therefore, nanomediated isoniazid (INH)-loaded dry powder for inhalation (Nano-DPI) was developed for macrophage-targeted delivery in TB
Externí odkaz:
https://doaj.org/article/783108c4c97f4abda85cc4ad774774b0
Autor:
Rubén Varela-Fernández, Xurxo García-Otero, Victoria Díaz-Tomé, Uxía Regueiro, Maite López-López, Miguel González-Barcia, María Isabel Lema, Francisco Javier Otero-Espinar
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 799 (2022)
Background: the present work describes the preparation, characterization and optimization of eight types of PLGA-based nanosystems (nanospheres and nanocapsules) as innovative mucoadhesive drug delivery systems of lactoferrin, in order to achieve a p
Externí odkaz:
https://doaj.org/article/ed0ce7ca83ee4f29a961f2bc4f94c639
Autor:
Oscar J. Cordero, Carlos Rafael-Vidal, Rubén Varela-Calviño, Cristina Calviño-Sampedro, Beatriz Malvar-Fernández, Samuel García, Juan E. Viñuela, José M. Pego-Reigosa
Publikováno v:
Biomolecules, Vol 11, Iss 10, p 1446 (2021)
Immune system CD4 T-cells with high cell-surface CD26 expression show anti-tumoral properties. When engineered with a chimeric antigen receptor (CAR), they incite strong responses against solid cancers. This subset was originally associated to human
Externí odkaz:
https://doaj.org/article/d163e384812a4e869d2b38b6c16b6ba5
Autor:
Rui Seabra, Rubén Varela, António M. Santos, Moncho Gómez-Gesteira, Claudia Meneghesso, David S. Wethey, Fernando P. Lima
Publikováno v:
Frontiers in Marine Science, Vol 6 (2019)
Coastal marine biodiversity within eastern boundary upwelling systems (EBUS) is closely linked to the cooler sea temperatures associated with them. It has been suggested that global warming could lead to enhanced sea surface cooling in EBUS via the i
Externí odkaz:
https://doaj.org/article/27e9ea4e7c7a4aaea4b8ee3588f85ce6
Autor:
Xurxo García-Otero, Victoria Díaz-Tomé, Rubén Varela-Fernández, Manuel Martín-Pastor, Miguel González-Barcia, José Blanco-Méndez, Cristina Mondelo-García, Maria A. Bermudez, Francisco Gonzalez, Pablo Aguiar, Anxo Fernández-Ferreiro, Francisco J. Otero-Espinar
Publikováno v:
Pharmaceutics, Vol 13, Iss 2, p 149 (2021)
Uveitis is a vision inflammatory disorder with a high prevalence in developing countries. Currently, marketed treatments remain limited and reformulation is usually performed to obtain a tacrolimus eye drop as a therapeutic alternative in corticoster
Externí odkaz:
https://doaj.org/article/870874844d6d4b1da97542204be64b6d
Autor:
Rubén Varela-Fernández, Victoria Díaz-Tomé, Andrea Luaces-Rodríguez, Andrea Conde-Penedo, Xurxo García-Otero, Asteria Luzardo-Álvarez, Anxo Fernández-Ferreiro, Francisco J. Otero-Espinar
Publikováno v:
Pharmaceutics, Vol 12, Iss 3, p 269 (2020)
The treatment of the posterior-segment ocular diseases, such as age-related eye diseases (AMD) or diabetic retinopathy (DR), present a challenge for ophthalmologists due to the complex anatomy and physiology of the eye. This specialized organ is comp
Externí odkaz:
https://doaj.org/article/c812ef98945f4b819330a7ad7e35a147