Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rubén Soto-Acosta"'
Autor:
Rubén Soto-Acosta, Patricia Bautista-Carbajal, Margot Cervantes-Salazar, Antonio H Angel-Ambrocio, Rosa M Del Angel
Publikováno v:
PLoS Pathogens, Vol 13, Iss 4, p e1006257 (2017)
Dengue is the most common mosquito-borne viral disease in humans. Changes of lipid-related metabolites in endoplasmic reticulum of dengue virus (DENV) infected cells have been associated with replicative complexes formation. Previously, we reported t
Externí odkaz:
https://doaj.org/article/7c3f4be56cfc4db7858ee4c5c9703f18
Autor:
Eshwar R, Tammineni, Elba D, Carrillo, Rubén, Soto-Acosta, Antonio H, Angel-Ambrocio, María C, García, Patricia, Bautista-Carbajal, Rosa M, Del Angel, Jorge A, Sánchez
Publikováno v:
Science signaling. 11(560)
The auxiliary β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::94dddb3ef025c92838db3decb8f4f8ef
https://pubmed.ncbi.nlm.nih.gov/30538175
https://pubmed.ncbi.nlm.nih.gov/30538175
Publikováno v:
Molecules, Vol 27, Iss 18, p 6109 (2022)
To search for Zika virus (ZIKV) antivirals, we have further explored previously reported 7H-pyrrolo[2,3-d]pyrimidines by examining an alternative substitution pattern of their central scaffold, leading to compound 5 with low micromolar antiviral acti
Externí odkaz:
https://doaj.org/article/f944d6773a5b4f69b532981979d310bc
Autor:
Ruben Soto-Acosta, Tiffany C. Edwards, Christine D. Dreis, Venkatramana D. Krishna, Maxim C-J. Cheeran, Li Qiu, Jiashu Xie, Laurent F. Bonnac, Robert J. Geraghty
Publikováno v:
Viruses, Vol 13, Iss 12, p 2508 (2021)
Broad-spectrum antiviral therapies hold promise as a first-line defense against emerging viruses by blunting illness severity and spread until vaccines and virus-specific antivirals are developed. The nucleobase favipiravir, often discussed as a broa
Externí odkaz:
https://doaj.org/article/4ed7d485443143e19662aa390f9377fb
Publikováno v:
Molecules, Vol 26, Iss 13, p 3779 (2021)
Discovery of compound 1 as a Zika virus (ZIKV) inhibitor has prompted us to investigate its 7H-pyrrolo[2,3-d]pyrimidine scaffold, revealing structural features that elicit antiviral activity. Furthermore, we have demonstrated that 9H-purine or 1H-pyr
Externí odkaz:
https://doaj.org/article/4eb03b91a3d74e30a93c520ef7dcb865
Autor:
Ruben Soto-Acosta, Xuping Xie, Chao Shan, Coleman K Baker, Pei-Yong Shi, Shannan L Rossi, Mariano A Garcia-Blanco, Shelton Bradrick
Publikováno v:
eLife, Vol 7 (2018)
Subgenomic flaviviral RNA (sfRNA) accumulates during infection due to incomplete degradation of viral genomes and interacts with cellular proteins to promote infection. Here we identify host proteins that bind the Zika virus (ZIKV) sfRNA. We identifi
Externí odkaz:
https://doaj.org/article/200e02bf34774f20a077dc4c0581b8e2
Autor:
Julien Pompon, Menchie Manuel, Geok Kee Ng, Benjamin Wong, Chao Shan, Gayathri Manokaran, Ruben Soto-Acosta, Shelton S Bradrick, Eng Eong Ooi, Dorothée Missé, Pei-Yong Shi, Mariano A Garcia-Blanco
Publikováno v:
PLoS Pathogens, Vol 13, Iss 7, p e1006535 (2017)
Globally re-emerging dengue viruses are transmitted from human-to-human by Aedes mosquitoes. While viral determinants of human pathogenicity have been defined, there is a lack of knowledge of how dengue viruses influence mosquito transmission. Identi
Externí odkaz:
https://doaj.org/article/2e0386c04b854bb8ac00eaedbdbae51a
Publikováno v:
Viruses, Vol 9, Iss 6, p 137 (2017)
Flaviviruses are enveloped arthropod-borne viruses with a single-stranded, positive-sense RNA genome that can cause serious illness in humans and animals. The 11 kb 5′ capped RNA genome consists of a single open reading frame (ORF), and is flanked
Externí odkaz:
https://doaj.org/article/63872056c89e42d79c6205dc8e400212