Influence of a new botanical combination on quality of life in menopausal Spanish women: Results of a randomized, placebo-controlled pilot study.

Autor: Laura López-Ríos, Miguel A Barber, Julia Wiebe, Rubén P Machín, Tanausú Vega-Morales, Ricardo Chirino

Publikováno v: PLoS ONE, Vol 16, Iss 7, p e0255015 (2021)

BackgroundThis study was designed to evaluate the beneficial effects of a botanical extract combination containing soy isoflavone extract (100mg), Aframomum melegueta seed dry extract (50 mg), and Punica granatum skin dry extract (100mg) on health-re

Externí odkaz: https://doaj.org/article/64401edd928b428bb34fd31691196673

Searching for novel molecular targets of chronic rejection in an orthotopic experimental lung transplantation model

Autor: Rubén P. Machín, Ana López-García, Leandro Fernández-Pérez, Yanira Brito, José A. Ruíz-Caballero, Juan C. Rodríguez-Bermejo, Pedro Llontop, Bernardino Clavo, José Manuel García-Castellano, Miguel A. Ponce-González, María D. Fiuza, Norberto Santana-Rodríguez, Jesús Villar, Ricardo García-Herrera

Publikováno v: The Journal of Heart and Lung Transplantation. 31:213-221

Background Chronic rejection (CR) is the main reason for the limited survival rates among lung transplant (LT) recipients. There remains no effective treatment for CR. The aim of this study was to identify new molecular mechanisms involved in CR by u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a23c7e22e78f5d314acb2894e3f86d08
https://doi.org/10.1016/j.healun.2011.11.011

γ-Lactones α,β- and β,γ-fused to carbocycles as novel antiproliferative drugs

Autor: Carmen M. Rodríguez, José L. Ravelo, Leticia G. Leon, José M. Padrón, Víctor S. Martín, Rubén P. Machín

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:5171-5173

A set of γ-lactones α,β-fused and β,γ-fused to carbocycles have been synthesized and evaluated for their in vitro antiproliferative activities using the human cancer cell lines SW1573 (lung), T-47D (breast) and WiDr (colon). The compounds are ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75eb4ec3a38bb280c71fcdaf2e1f2727
https://doi.org/10.1016/j.bmcl.2008.08.098

Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and application of statins as a novel effective therapeutic approach against Acanthamoeba infections

Autor: Jacob Lorenzo-Morales, Sutherland K. Maciver, Isabel Fuentes, José Manuel García-Castellano, Basilio Valladares, Brendan J. Loftus, Rubén P. Machín, Carmen María Martín-Navarro, Atteneri López-Arencibia, José E. Piñero

Publikováno v: Maria Martin-Navarro, C, Lorenzo-Morales, J, Machin, R P, Lopez-Arencibia, A, Manuel Garcia-Castellano, J, de Fuentes, I, Loftus, B, Maciver, S K, Valladares, B & Pineroa, J E 2013, ' Inhibition of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase and Application of Statins as a Novel Effective Therapeutic Approach against Acanthamoeba Infections ', Antimicrobial Agents and Chemotherapy, vol. 57, no. 1, pp. 375-381 . https://doi.org/10.1128/AAC.01426-12

Acanthamoeba is an opportunistic pathogen in humans, whose infections most commonly manifest as Acanthamoeba keratitis or, more rarely, granulomatous amoebic encephalitis. Although there are many therapeutic options for the treatment of Acanthamoeba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a632ab666e8ac1a2054c72f127af2a13
https://pubmed.ncbi.nlm.nih.gov/23114753

Acanthamoeba spp.: in vitro effects of clinical isolates on murine macrophages, osteosarcoma and HeLa cells

Autor: José E. Piñero, Rubén P. Machín, Jacob Lorenzo-Morales, Atteneri López-Arencibia, Basilio Valladares, Carmen M. Martín-Navarro

Publikováno v: Experimental parasitology. 126(1)

Three different cell lines (murine macrophages, HeLa and osteosarcoma cells) were assayed in order to check for the manifestation of the cytopathic effects of three strains of Acanthamoeba recently isolated in our laboratory from contact lens cases:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675c947f219282114ea1b192650081cc
https://pubmed.ncbi.nlm.nih.gov/19857490