Integrated Post-GWAS Analysis Sheds New Light on the Disease Mechanisms of Schizophrenia

Autor: Quanwei Zhang, Rubén Nogales-Cadenas, Jhih Rong Lin, Wen Zhang, Ying Cai, Zhengdong D. Zhang

Publikováno v: Genetics. 204:1587-1600

Schizophrenia is a severe mental disorder with a large genetic component. Recent genome-wide association studies (GWAS) have identified many schizophrenia-associated common variants. For most of the reported associations, however, the underlying biol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a337f2383e73cc1589dbe02fc4d3976
https://doi.org/10.1534/genetics.116.187195

Distinct Molecular Signature of Murine Fetal Liver and Adult Hematopoietic Stem Cells Identify Novel Regulators of Hematopoietic Stem Cell Function

Autor: Javed Karim Manesia, Rubén Nogales-Cadenas, Elisa Van Den Bosch, Catherine M. Verfaillie, Thomas Vanwelden, Mónica Franch, Daniel Tabas-Madrid, Satish Khurana, Alberto Pascual-Montano, Zhuofei Xu

During ontogeny, fetal liver (FL) acts as a major site for hematopoietic stem cell (HSC) maturation and expansion, whereas HSCs in the adult bone marrow (ABM) are largely quiescent. HSCs in the FL possess faster repopulation capacity as compared with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1323288e414999caaee75b22ddc068b8
https://europepmc.org/articles/PMC5961932/

Prioritization of Schizophrenia Risk Genes by a Network-Regularized Logistic Regression Method

Autor: Jhin Rong Lin, Ying Cai, Quanwei Zhang, Rubén Nogales-Cadenas, Wen Zhang, Zhengdong D. Zhang

Publikováno v: Bioinformatics and Biomedical Engineering ISBN: 9783319317434
IWBBIO

Schizophrenia (SCZ) is a severe mental disorder with a large genetic component. While recent large-scale microarray- and sequencing-based genome wide association studies have made significant progress toward finding SCZ risk variants and genes of sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b4e8b66e002e8fc20495d64f63f2cd8
https://doi.org/10.1007/978-3-319-31744-1_39

GeneCodis: interpreting gene lists through enrichment analysis and integration of diverse biological information

Autor: José María Carazo, Francisco Tirado, Miguel Vazquez, Rubén Nogales-Cadenas, Xiaoyuan Yang, Alberto Pascual-Montano, Cesar Vicente, Pedro Carmona-Sáez

Publikováno v: E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
Nucleic Acids Research
Nucleic Acids Research; Vol 37
E-Prints Complutense. Archivo Institucional de la UCM
instname

Medical imaging has become an absolutely essential diagnostic tool for clinical practices; at present, pathologies can be detected with an earliness never before known. Its use has not only been relegated to the field of radiology but also, increasin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824ff30e6b98802198e686394a4f2970
https://doi.org/10.1093/nar/gkp416

From Gene Expression to Disease Phenotypes: Network-Based Approaches to Study Complex Human Diseases

Autor: Rubén Nogales-Cadenas, Jhin-Rong Lin, Ying Cai, Zhengdong D. Zhang, Wen Zhang, Quanwei Zhang

Publikováno v: Translational Bioinformatics ISBN: 9789401774482

Gene expression is a fundamental biological process under tight regulation at all levels in normal cells. Its dysregulation can cause abnormal cell behaviors and result in diseases, and thus gene expression profiling and analysis have been widely use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eac275d017ce22365eb62a144d270429
https://doi.org/10.1007/978-94-017-7450-5_5