Metamorphism in TDP-43 prion-like domain determines chaperone recognition

Autor: Jaime Carrasco, Rosa Antón, Alejandro Valbuena, David Pantoja-Uceda, Mayur Mukhi, Rubén Hervás, Douglas V. Laurents, María Gasset, Javier Oroz

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

In this work, the authors show that metamorphism in the post-translationally modified TDP-43 prion-like domain encodes determinants that command mechanisms with major relevance in disease and stress the relevance of post-translationally modified chai

Externí odkaz: https://doaj.org/article/9a9166e33ea74700a35643c8927458e0

Mechanistic Insights into the Role of Molecular Chaperones in Protein Misfolding Diseases: From Molecular Recognition to Amyloid Disassembly

Autor: Rubén Hervás, Javier Oroz

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 23, p 9186 (2020)

Age-dependent alterations in the proteostasis network are crucial in the progress of prevalent neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, or amyotrophic lateral sclerosis, which are characterized by the presence of insoluble pr

Externí odkaz: https://doaj.org/article/a04aa6b60c1c47599685f481bd834a17

Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation.

Autor: Rubén Hervás, Liying Li, Amitabha Majumdar, María Del Carmen Fernández-Ramírez, Jay R Unruh, Brian D Slaughter, Albert Galera-Prat, Elena Santana, Mari Suzuki, Yoshitaka Nagai, Marta Bruix, Sergio Casas-Tintó, Margarita Menéndez, Douglas V Laurents, Kausik Si, Mariano Carrión-Vázquez

Publikováno v: PLoS Biology, Vol 14, Iss 1, p e1002361 (2016)

Amyloids are ordered protein aggregates that are typically associated with neurodegenerative diseases and cognitive impairment. By contrast, the amyloid-like state of the neuronal RNA binding protein Orb2 in Drosophila was recently implicated in memo

Externí odkaz: https://doaj.org/article/77f95cb5f9284cf6befdeef4b438bc58

Expanded Conformations of Monomeric Tau Initiate Its Amyloidogenesis

Autor: María del Carmen Fernández‐Ramírez, Kevin Kan‐Shing Ng, Margarita Menéndez, Douglas V. Laurents, Rubén Hervás, Mariano Carrión‐Vázquez

Publikováno v: Angewandte Chemie (International ed. in English).

11 pags., 5 figs.
Understanding early amyloidogenesis is key to rationally develop therapeutic strategies. Tau protein forms well-characterized pathological deposits but its aggregation mechanism is still poorly understood. Using single-molecule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec41f38ddd764f706719f308e941755
https://pubmed.ncbi.nlm.nih.gov/36542681

Divergent CPEB prion-like domains reveal different assembly mechanisms for a generic amyloid-like fold

Autor: Mari Suzuki, Douglas V. Laurents, Albert Galera-Prat, Yoshitaka Nagai, Mariano Carrión-Vázquez, Marta Bruix, Margarita Menéndez, Rubén Hervás, María del Carmen Fernández-Ramírez

Publikováno v: Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
BMC Biology
BMC Biology, Vol 19, Iss 1, Pp 1-14 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname

14 pags., 4 figs.
Background: Amyloids are ordered, insoluble protein aggregates, characterized by a cross-β sheet quaternary structure in which molecules in a β-strand conformation are stacked along the filament axis via intermolecular intera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920c6b7a6e21dc19b043268434fc4ce3
http://hdl.handle.net/10261/248470