Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Rubén E. Varela-M."'
Autor:
Christian Bustamante, Andrés Felipe Díez-Mejía, Natalia Arbeláez, Maurilio José Soares, Sara M. Robledo, Rodrigo Ochoa, Rubén E. Varela-M., Marcel Marín-Villa
Publikováno v:
Pathogens, Vol 11, Iss 6, p 616 (2022)
The lack of therapeutic alternatives for the treatment of Chagas disease, a neglected disease, drives the discovery of new drugs with trypanocidal activity. Consequently, we conducted in vitro studies using UBMC-4, a potential Trypanosoma cruzi AKT-l
Externí odkaz:
https://doaj.org/article/accd649222414eeeaed25721cc212126
Autor:
Rodrigo Ochoa, Amaya Ortega-Pajares, Florencia A. Castello, Federico Serral, Darío Fernández Do Porto, Janny A. Villa-Pulgarin, Rubén E. Varela-M, Carlos Muskus
Publikováno v:
Biomolecules, Vol 11, Iss 7, p 1037 (2021)
Leishmaniasis is a public health disease that requires the development of more effective treatments and the identification of novel molecular targets. Since blocking the PI3K/AKT pathway has been successfully studied as an effective anticancer strate
Externí odkaz:
https://doaj.org/article/d8b62333c2da49bfb36bbea6ccf1300b
Publikováno v:
The Open Medicinal Chemistry Journal. 14:45-48
Background: Cancer is one of the most common diseases in the world, with over 18 million new cases estimated in 2018. Many of the drugs used for cancer can have significant adverse effects and variable effectiveness. Nitroimidazoles are prodrugs that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a06256a1da5bfa6061d50c63ea698be
https://doi.org/10.2174/1874104502014010045
https://doi.org/10.2174/1874104502014010045
Autor:
Edward Yepes, Rubén E Varela-M, Julio López-Abán, Jose Rojas-Caraballo, Antonio Muro, Faustino Mollinedo
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 7, p e0003893 (2015)
Schistosomiasis is the third most devastating tropical disease worldwide caused by blood flukes of the genus Schistosoma. This parasitic disease is due to immunologic reactions to Schistosoma eggs trapped in tissues. Egg-released antigens stimulate t
Externí odkaz:
https://doaj.org/article/e9079f217336471bbd2ff715b720c0df
Publikováno v:
Journal of Environmental Management. 322:116159
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f5793494147cd96a7b308b1d75b20bb
https://doi.org/10.1016/j.jenvman.2022.116159
https://doi.org/10.1016/j.jenvman.2022.116159
Autor:
Edward Yepes, Rubén E Varela-M, Julio López-Abán, El Habib Dakir, Faustino Mollinedo, Antonio Muro
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109431 (2014)
BACKGROUND: Schistosomiasis is a parasitic disease caused by trematodes of the genus Schistosoma. Five species of Schistosoma are known to infect humans, out of which S. haematobium is the most prevalent, causing the chronic parasitic disease schisto
Externí odkaz:
https://doaj.org/article/ad70c884f3884ea0bf45b4487c04ea36
Autor:
Rubén E Varela-M, Janny A Villa-Pulgarin, Edward Yepes, Ingrid Müller, Manuel Modolell, Diana L Muñoz, Sara M Robledo, Carlos E Muskus, Julio López-Abán, Antonio Muro, Iván D Vélez, Faustino Mollinedo
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 4, p e1612 (2012)
BACKGROUND: The leishmaniases are a complex of neglected tropical diseases caused by more than 20 Leishmania parasite species, for which available therapeutic arsenal is scarce and unsatisfactory. Pentavalent antimonials (SbV) are currently the first
Externí odkaz:
https://doaj.org/article/1a8c62ffbbea481489e277e0e09c0a99
Publikováno v:
Biomédica: revista del Instituto Nacional de Salud, Vol 38, Iss 1, Pp 111-119 (2018)
Biomédica, Volume: 38, Issue: 1, Pages: 111-119, Published: JAN 2018
Biomédica, Volume: 38, Issue: 1, Pages: 111-119, Published: JAN 2018
Resumen Introducción. En el mundo, las angiostrongilosis de mayor impacto en salud humana y animal son ocasionadas por Angiostrongylus cantonensis, A. costaricensis y A. vasorum. En las personas, las formas clínicas son la meningitis eosinofílica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ab8638cb3f2e6146e15288c354b340
https://www.revistabiomedica.org/index.php/biomedica/article/view/3407
https://www.revistabiomedica.org/index.php/biomedica/article/view/3407
Autor:
Rubén E. Varela-M, Rodrigo Ochoa, Janny A. Villa-Pulgarin, Florencia Andrea Castello, Darío Fernández Do Porto, Amaya Ortega-Pajares, Federico Serral, Carlos Muskus
Publikováno v:
Biomolecules, Vol 11, Iss 1037, p 1037 (2021)
Biomolecules
Volume 11
Issue 7
Biomolecules
Volume 11
Issue 7
Leishmaniasis is a public health disease that requires the development of more effective treatments and the identification of novel molecular targets. Since blocking the PI3K/AKT pathway has been successfully studied as an effective anticancer strate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6c37a7bf523a26f6ce9cda8eed4bd3
https://doi.org/10.3390/biom11071037
https://doi.org/10.3390/biom11071037
Search of Allosteric Inhibitors and Associated Proteins of an AKT-like Kinase from Trypanosoma cruzi
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 19, Iss 12, p 3951 (2018)
Volume 19
Issue 12
International Journal of Molecular Sciences, Vol 19, Iss 12, p 3951 (2018)
Volume 19
Issue 12
Proteins associated to the PI3K/AKT/mTOR signaling pathway are widely used targets for cancer treatment, and in recent years they have also been evaluated as putative targets in trypanosomatids parasites, such as Trypanosoma cruzi. Here, we performed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e758a022cf4cab1a5b1ddbebcb5623
http://europepmc.org/articles/PMC6321509
http://europepmc.org/articles/PMC6321509