Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.

Autor: Janny A Villa-Pulgarín, Consuelo Gajate, Javier Botet, Alberto Jimenez, Nicole Justies, Rubén E Varela-M, Álvaro Cuesta-Marbán, Ingrid Müller, Manuel Modolell, José L Revuelta, Faustino Mollinedo

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 8, p e0005805 (2017)

Leishmaniasis is the world's second deadliest parasitic disease after malaria, and current treatment of the different forms of this disease is far from satisfactory. Alkylphospholipid analogs (APLs) are a family of anticancer drugs that show antileis

Externí odkaz: https://doaj.org/article/b4bc8ef28cd54018b172542ea561c88d

In vitro and in vivo anti-schistosomal activity of the alkylphospholipid analog edelfosine.

Autor: Edward Yepes, Rubén E Varela-M, Julio López-Abán, El Habib Dakir, Faustino Mollinedo, Antonio Muro

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e109431 (2014)

BACKGROUND: Schistosomiasis is a parasitic disease caused by trematodes of the genus Schistosoma. Five species of Schistosoma are known to infect humans, out of which S. haematobium is the most prevalent, causing the chronic parasitic disease schisto

Externí odkaz: https://doaj.org/article/ad70c884f3884ea0bf45b4487c04ea36

Identification of Potential Kinase Inhibitors within the PI3K/AKT Pathway of Leishmania Species

Autor: Rodrigo Ochoa, Amaya Ortega-Pajares, Florencia A. Castello, Federico Serral, Darío Fernández Do Porto, Janny A. Villa-Pulgarin, Rubén E. Varela-M, Carlos Muskus

Publikováno v: Biomolecules, Vol 11, Iss 7, p 1037 (2021)

Leishmaniasis is a public health disease that requires the development of more effective treatments and the identification of novel molecular targets. Since blocking the PI3K/AKT pathway has been successfully studied as an effective anticancer strate

Externí odkaz: https://doaj.org/article/d8b62333c2da49bfb36bbea6ccf1300b

Antitumor Activity In Vitro Provided by N-Alkyl-Nitroimidazole Compounds

Autor: Rubén E. Varela-M, Constain H. Salamanca, Jose Oñate-Garzón, Janny A. Villa-Pulgarin

Publikováno v: The Open Medicinal Chemistry Journal. 14:45-48

Background: Cancer is one of the most common diseases in the world, with over 18 million new cases estimated in 2018. Many of the drugs used for cancer can have significant adverse effects and variable effectiveness. Nitroimidazoles are prodrugs that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a06256a1da5bfa6061d50c63ea698be
https://doi.org/10.2174/1874104502014010045

Estandarización de una prueba múltiple de reacción en cadena de la polimerasa en tiempo real para la identificación de Angiostrongylus cantonensis, A. costaricensis y A. vasorum

Autor: Jinney Stefany Arias, Luz Elena Velásquez, Rubén E. Varela-M

Publikováno v: Biomédica: revista del Instituto Nacional de Salud, Vol 38, Iss 1, Pp 111-119 (2018)
Biomédica, Volume: 38, Issue: 1, Pages: 111-119, Published: JAN 2018

Resumen Introducción. En el mundo, las angiostrongilosis de mayor impacto en salud humana y animal son ocasionadas por Angiostrongylus cantonensis, A. costaricensis y A. vasorum. En las personas, las formas clínicas son la meningitis eosinofílica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ab8638cb3f2e6146e15288c354b340
https://www.revistabiomedica.org/index.php/biomedica/article/view/3407