Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rubèn Quintana-Cabrera"'
Autor:
Francesco Chemello, Michela Pozzobon, Lorenza Iolanda Tsansizi, Tatiana Varanita, Rubèn Quintana-Cabrera, Daniele Bonesso, Martina Piccoli, Gerolamo Lanfranchi, Marta Giacomello, Luca Scorrano, Camilla Bean
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-13 (2023)
Abstract The approved gene therapies for spinal muscular atrophy (SMA), caused by loss of survival motor neuron 1 (SMN1), greatly ameliorate SMA natural history but are not curative. These therapies primarily target motor neurons, but SMN1 loss has d
Externí odkaz:
https://doaj.org/article/b774fc702e994e658b7dca7d1a915dc5
Autor:
Irene Lopez-Fabuel, Marina Garcia-Macia, Costantina Buondelmonte, Olga Burmistrova, Nicolo Bonora, Paula Alonso-Batan, Brenda Morant-Ferrando, Carlos Vicente-Gutierrez, Daniel Jimenez-Blasco, Ruben Quintana-Cabrera, Emilio Fernandez, Jordi Llop, Pedro Ramos-Cabrer, Aseel Sharaireh, Marta Guevara-Ferrer, Lorna Fitzpatrick, Christopher D. Thompton, Tristan R. McKay, Stephan Storch, Diego L. Medina, Sara E. Mole, Peter O. Fedichev, Angeles Almeida, Juan P. Bolaños
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
CLN7 neuronal ceroid lipofuscinosis is an inherited lysosomal storage disease typically with childhood onset of neurodegenerative symptoms. Here the authors report that in a mouse model of CLN7 disease neuronal reactive oxygen species and the activit
Externí odkaz:
https://doaj.org/article/3a651b3190b84e729467d309cc661713
Autor:
Marta Zaninello, Konstantinos Palikaras, Deborah Naon, Keiko Iwata, Stephanie Herkenne, Ruben Quintana-Cabrera, Martina Semenzato, Francesca Grespi, Fred N. Ross-Cisneros, Valerio Carelli, Alfredo A. Sadun, Nektarios Tavernarakis, Luca Scorrano
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Autosomal dominant optic atrophy is caused by mutations in the mitochondrial fusion protein OPA1. Here, the authors show that AMPK-induced autophagy depletes mitochondria in axons of retinal ganglion cells and that autophagic inhibition reverses visi
Externí odkaz:
https://doaj.org/article/85cc1dcbdee340b78b661df3a14cc334
Autor:
Marina Fuertes-Agudo, María Luque-Tévar, Carme Cucarella, Rocío Brea, Lisardo Boscá, Rubén Quintana-Cabrera, Paloma Martín-Sanz, Marta Casado
Publikováno v:
Antioxidants, Vol 11, Iss 9, p 1724 (2022)
Cyclooxygenase 2 (COX-2) is a key enzyme in prostanoid biosynthesis. The constitutive hepatocyte expression of COX-2 has a protective role in hepatic ischemia-reperfusion (I/R) injury (IRI), decreasing necrosis, reducing reactive oxygen species (ROS)
Externí odkaz:
https://doaj.org/article/7197fd7a025544b8bb11315bc738e3b0
Autor:
Rubén Quintana-Cabrera, Israel Manjarrés-Raza, Carlos Vicente-Gutiérrez, Mauro Corrado, Juan P. Bolaños, Luca Scorrano
Publikováno v:
Redox Biology, Vol 41, Iss , Pp 101944- (2021)
Reactive oxygen species (ROS) are a common product of active mitochondrial respiration carried in mitochondrial cristae, but whether cristae shape influences ROS levels is unclear. Here we report that the mitochondrial fusion and cristae shape protei
Externí odkaz:
https://doaj.org/article/0fb0517a992c4b07874dc305e95be298
Autor:
Rubén Quintana-Cabrera, Charlotte Quirin, Christina Glytsou, Mauro Corrado, Andrea Urbani, Anna Pellattiero, Enrique Calvo, Jesús Vázquez, José Antonio Enríquez, Christoph Gerle, María Eugenia Soriano, Paolo Bernardi, Luca Scorrano
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Mitochondrial cristae shape influences apoptosis and respiration. Here the authors show that the mitochondrial fusion protein OPA1 protects mitochondria from dysfunction by promoting ATP synthase oligomerization and reversal activity.
Externí odkaz:
https://doaj.org/article/a66df5bbbc5c4ae5970022ce8e2ac008
Autor:
Roberto Costa, Roberta Peruzzo, Magdalena Bachmann, Giulia Dalla Montà, Mattia Vicario, Giulia Santinon, Andrea Mattarei, Enrico Moro, Rubén Quintana-Cabrera, Luca Scorrano, Massimo Zeviani, Francesca Vallese, Mario Zoratti, Cristina Paradisi, Francesco Argenton, Marisa Brini, Tito Calì, Sirio Dupont, Ildikò Szabò, Luigi Leanza
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 1949-1960.e6 (2019)
Summary: Wnt signaling affects fundamental development pathways and, if aberrantly activated, promotes the development of cancers. Wnt signaling is modulated by different factors, but whether the mitochondrial energetic state affects Wnt signaling is
Externí odkaz:
https://doaj.org/article/077b21d8e4ff458c9f6ba31149cf7656
Autor:
Anna Maria Cseh, Zsolt Fabian, Ruben Quintana-Cabrera, Aliz Szabo, Krisztian Eros, Maria Eugenia Soriano, Ferenc Gallyas, Luca Scorrano, Balazs Sumegi
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
PARP-1 inhibition has recently been employed in both mono- and combination therapies in various malignancies including melanoma with both promising and contradicting results reported. Although deeper understanding of the underlying molecular mechanis
Externí odkaz:
https://doaj.org/article/f381065919764ca58bfa19b4e21df72f