The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms.

Autor: Pham TCP; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Raun SH; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Havula E; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Henriquez-Olguín C; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.; Exercise Science Laboratory, Faculty of Medicine, Universidad Finis Terrae, Av. Pedro de Valdivia 1509, Santiago, Chile., Rubalcava-Gracia D; Division of Molecular Metabolism, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Frank E; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Fritzen AM; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jannig PR; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, SE-17177, Stockholm, Sweden., Andersen NR; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark., Kruse R; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark., Ali MS; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Irazoki A; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Halling JF; Department of Biology, University of Copenhagen, Copenhagen, Denmark., Ringholm S; Department of Biology, University of Copenhagen, Copenhagen, Denmark., Needham EJ; Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia., Hansen S; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark., Lemminger AK; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark., Schjerling P; Institute of Sports Medicine Copenhagen, Department of Orthopaedic Surgery M, Bispebjerg Hospital, Copenhagen, Denmark.; Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Petersen MH; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark., de Almeida ME; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark., Jensen TE; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark., Kiens B; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark., Hostrup M; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark., Larsen S; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Institute of Sports Medicine Copenhagen, Department of Orthopaedic Surgery M, Bispebjerg Hospital, Copenhagen, Denmark.; Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland., Ørtenblad N; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark., Højlund K; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Kjær M; Institute of Sports Medicine Copenhagen, Department of Orthopaedic Surgery M, Bispebjerg Hospital, Copenhagen, Denmark.; Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ruas JL; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, SE-17177, Stockholm, Sweden., Trifunovic A; Institute for Mitochondrial Diseases and Aging, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), Medical Faculty, University of Cologne, Cologne, Germany., Wojtaszewski JFP; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark., Nielsen J; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark., Qvortrup K; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pilegaard H; Department of Biology, University of Copenhagen, Copenhagen, Denmark., Richter EA; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark., Sylow L; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark. Lykkesylow@sund.ku.dk.; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Lykkesylow@sund.ku.dk.

Publikováno v: Nature communications [Nat Commun] 2024 Nov 13; Vol. 15 (1), pp. 9826. Date of Electronic Publication: 2024 Nov 13.

A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue.

Autor: Wadsworth BJ; Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden., Leiwe M; Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden., Minogue EA; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom., Cunha PP; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom., Engman V; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden., Brombach C; Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden., Asvestis C; Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden., Sah-Teli SK; Faculty of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland.; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom., Marklund E; Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden., Koivunen P; Faculty of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland., Ruas JL; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden., Rundqvist H; Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden., Lanner JT; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden., Johnson RS; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.

Publikováno v: ELife [Elife] 2024 Sep 03; Vol. 12. Date of Electronic Publication: 2024 Sep 03.

Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition.

Autor: Ducommun S; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden., Jannig PR; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden., Cervenka I; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden., Murgia M; Department of Biomedical Sciences, University of Padova, Via Ugo Bassi, 58/B, 35131 Padua, Italy; Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany., Mittenbühler MJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA., Chernogubova E; Department of Medicine, Cardiovascular Unit, Karolinska Institutet, 171 77 Stockholm, Sweden., Dias JM; Department of Cell and Molecular Biology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden; Nanomedicine and Spatial Biology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden., Jude B; Molecular Muscle Physiology and Pathophysiology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden., Correia JC; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden., Van Vranken JG; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA., Ocana-Santero G; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden., Porsmyr-Palmertz M; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden., McCann Haworth S; Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden., Martínez-Redondo V; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden., Liu Z; Molecular Muscle Physiology and Pathophysiology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden., Carlström M; Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden., Mann M; Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany., Lanner JT; Molecular Muscle Physiology and Pathophysiology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden., Teixeira AI; Nanomedicine and Spatial Biology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden., Maegdefessel L; Department of Medicine, Cardiovascular Unit, Karolinska Institutet, 171 77 Stockholm, Sweden; Institute of Molecular Vascular Medicine, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany; German Center for Cardiovascular Research DZHK, Partner Site Munich Heart Alliance, 10785 Berlin, Germany., Spiegelman BM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA., Ruas JL; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Pharmacology and Stanley and Judith Frankel Institute for Heart & Brain Health, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: jlruas@med.umich.edu.

Publikováno v: Molecular metabolism [Mol Metab] 2024 Apr; Vol. 82, pp. 101912. Date of Electronic Publication: 2024 Mar 06.

Multivalent insulin receptor activation using insulin-DNA origami nanostructures.

Autor: Spratt J; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Dias JM; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden., Kolonelou C; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Kiriako G; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Engström E; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Petrova E; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Karampelias C; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden., Cervenka I; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Papanicolaou N; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Lentini A; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Reinius B; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Andersson O; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden., Ambrosetti E; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.; Center for Life Nano- and Neuro-Science, Istituto Italiano di Tecnologia, Rome, Italy., Ruas JL; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Teixeira AI; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. Ana.Teixeira@ki.se.; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. Ana.Teixeira@ki.se.

Publikováno v: Nature nanotechnology [Nat Nanotechnol] 2024 Feb; Vol. 19 (2), pp. 237-245. Date of Electronic Publication: 2023 Oct 09.

Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration.

Autor: Correia JC; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum. Karolinska. SE-171 77, Stockholm, Sweden., Jannig PR; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum. Karolinska. SE-171 77, Stockholm, Sweden., Gosztyla ML; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, USA., Cervenka I; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum. Karolinska. SE-171 77, Stockholm, Sweden., Ducommun S; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum. Karolinska. SE-171 77, Stockholm, Sweden., Præstholm SM; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum. Karolinska. SE-171 77, Stockholm, Sweden., Dumont K; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum. Karolinska. SE-171 77, Stockholm, Sweden., Liu Z; Molecular Muscle Physiology and Pathophysiology. Department of Physiology and Pharmacology, Biomedicum. Karolinska Institutet. SE-171 77, Stockholm. Sweden., Liang Q; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, USA., Edsgärd D; Science for Life Laboratory, Department of Gene Technology, School of Engineering Sciences in Biotechnology, Chemistry and Health, KTH Royal Institute of Technology, Stockholm, Sweden., Emanuelsson O; Science for Life Laboratory, Department of Gene Technology, School of Engineering Sciences in Biotechnology, Chemistry and Health, KTH Royal Institute of Technology, Stockholm, Sweden., Gregorevic P; Centre for Muscle Research, Department of Anatomy and Physiology, School of Biomedical Sciences, The University of Melbourne, Melbourne, VIC, Australia., Westerblad H; Muscle Physiology, Department of Physiology and Pharmacology, Biomedicum. Karolinska. SE-171 77, Stockholm, Sweden., Venckunas T; Institute of Sports Science and Innovations, Lithuanian Sports University, 44221 Kaunas, Lithuania., Brazaitis M; Institute of Sports Science and Innovations, Lithuanian Sports University, 44221 Kaunas, Lithuania., Kamandulis S; Institute of Sports Science and Innovations, Lithuanian Sports University, 44221 Kaunas, Lithuania., Lanner JT; Molecular Muscle Physiology and Pathophysiology. Department of Physiology and Pharmacology, Biomedicum. Karolinska Institutet. SE-171 77, Stockholm. Sweden., Yeo GW; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, USA., Ruas JL; Molecular and Cellular Exercise Physiology, Department of Physiology and Pharmacology, Biomedicum. Karolinska. SE-171 77, Stockholm, Sweden.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 13. Date of Electronic Publication: 2023 Jun 13.