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CRISPR-Cas9-mediated genome editing delivered by a single AAV9 vector inhibits HSV-1 reactivation in a latent rabbit keratitis model.

Autor: Amrani N; Excision BioTherapeutics Inc, Watertown, MA, USA., Luk K; Excision BioTherapeutics Inc, Watertown, MA, USA., Singh P; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA., Shipley M; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA., Isik M; Excision BioTherapeutics Inc, Watertown, MA, USA., Donadoni M; Center for Neurovirology and Gene Editing, Department of Microbiology, Immunology and Inflammation, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA., Bellizzi A; Center for Neurovirology and Gene Editing, Department of Microbiology, Immunology and Inflammation, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA., Khalili K; Center for Neurovirology and Gene Editing, Department of Microbiology, Immunology and Inflammation, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA., Sariyer IK; Center for Neurovirology and Gene Editing, Department of Microbiology, Immunology and Inflammation, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA., Neumann D; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA., Gordon J; Excision BioTherapeutics Inc, Watertown, MA, USA., Ruan GX; Excision BioTherapeutics Inc, Watertown, MA, USA.

Publikováno v: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2024 Aug 14; Vol. 32 (3), pp. 101303. Date of Electronic Publication: 2024 Aug 14 (Print Publication: 2024).

Spliceosome component PHD finger 5A is essential for early B lymphopoiesis.

Autor: Zhang R; Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China., Wang D; Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China., Ruan GX; Medical School, Taizhou University, Taizhou 318000, China., Wang R; Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China., Li Y; Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China., Chen W; Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China., Huang H; Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China., Wang J; Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China., Meng L; Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China., Zhu Z; Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China., Lei D; Department of Ophthalmology, Southern University of Science and Technology Hospital, Shenzhen 518055, China., Xu S; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos, Singapore 138648, Republic of Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 2 Medical Drive MD9, Singapore 117593, Republic of Singapore., Ou X; Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.

Publikováno v: Development (Cambridge, England) [Development] 2024 Jan 15; Vol. 151 (2). Date of Electronic Publication: 2024 Jan 11.

The RNA-binding protein hnRNP F is required for the germinal center B cell response.

Autor: Huang H; School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China., Li Y; School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China., Zhang G; School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China., Ruan GX; Medical School, Taizhou University, Taizhou, 318000, China., Zhu Z; School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China., Chen W; School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China., Zou J; Department of Computer Science and Engineering, College of Engineering, Southern University of Science and Technology, Shenzhen, 518055, China., Zhang R; School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China., Wang J; School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China., Ouyang Y; School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China., Xu S; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, 138648, Singapore. xu_shengli@immunol.a-star.edu.sg.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore. xu_shengli@immunol.a-star.edu.sg., Ou X; School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China. ouxj@sustech.edu.cn.

Publikováno v: Nature communications [Nat Commun] 2023 Mar 30; Vol. 14 (1), pp. 1731. Date of Electronic Publication: 2023 Mar 30.

RNA-Editing Enzyme ADAR1 p150 Isoform Is Critical for Germinal Center B Cell Response.

Autor: Li Y; Harbin Institute of Technology, Harbin, China.; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China., Ruan GX; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China., Chen W; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China., Huang H; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China., Zhang R; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China., Wang J; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China., Li Y; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China; ouxj@sustech.edu.cn liy33@sustech.edu.cn., Xu S; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore; and.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Ou X; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China; ouxj@sustech.edu.cn liy33@sustech.edu.cn.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2022 Sep 15; Vol. 209 (6), pp. 1071-1082. Date of Electronic Publication: 2022 Aug 17.