The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions.

Autor: Irene Fasciani, Francesco Petragnano, Ziming Wang, Ruairidh Edwards, Narasimha Telugu, Ilaria Pietrantoni, Ulrike Zabel, Henrik Zauber, Marlies Grieben, Maria E Terzenidou, Jacopo Di Gregorio, Cristina Pellegrini, Silvano Santini, Anna R Taddei, Bärbel Pohl, Stefano Aringhieri, Marco Carli, Gabriella Aloisi, Francesco Marampon, Eve Charlesworth, Alexandra Roman, Sebastian Diecke, Vincenzo Flati, Franco Giorgi, Fernanda Amicarelli, Andrew B Tobin, Marco Scarselli, Kostas Tokatlidis, Mario Rossi, Martin J Lohse, Paolo Annibale, Roberto Maggio

Publikováno v: PLoS Biology, Vol 22, Iss 4, p e3002582 (2024)

Muscarinic acetylcholine receptors are prototypical G protein-coupled receptors (GPCRs), members of a large family of 7 transmembrane receptors mediating a wide variety of extracellular signals. We show here, in cultured cells and in a murine model,

Externí odkaz: https://doaj.org/article/55337ca4f8c84555b649a08804c2bd5c

The biogenesis of mitochondrial intermembrane space proteins

Autor: Sarah Gerlich, Kostas Tokatlidis, Ruairidh Edwards

Publikováno v: Biological Chemistry. 401:737-747

The mitochondrial intermembrane space (IMS) houses a large spectrum of proteins with distinct and critical functions. Protein import into this mitochondrial sub-compartment is underpinned by an intriguing variety of pathways, many of which are still

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef2035ec5a8829b1424891110dfde1b8
https://doi.org/10.1515/hsz-2020-0114

The mitochondrial protein Sideroflexin 3 (SFXN3) influences neurodegeneration pathways in vivo

Autor: Leire M. Ledahawsky, Maria Eirini Terzenidou, Ruairidh Edwards, Rachel A. Kline, Laura C. Graham, Samantha L. Eaton, Dinja van der Hoorn, Helena Chaytow, Yu‐Ting Huang, Ewout J. N. Groen, Anna A. L. Motyl, Douglas J. Lamont, Kostas Tokatlidis, Thomas M. Wishart, Thomas H. Gillingwater

Publikováno v: The FEBS journal. 289(13)

Synapses are a primary pathological target in neurodegenerative diseases. Identifying therapeutic targets at the synapse could delay progression of numerous conditions. The mitochondrial protein SFXN3 is a neuronally enriched protein expressed in syn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22fe7f223cfbdb8a1aeaca41cbf7ba44
https://pubmed.ncbi.nlm.nih.gov/35092170

AIF meets the CHCHD4/Mia40-dependent mitochondrial import pathway

Autor: Catherine Brenner, Kostas Tokatlidis, Nazanine Modjtahedi, Ruairidh Edwards, Kenza Nedara, Giuseppe Arena, Camille Reinhardt

Publikováno v: Biochimica et Biophysica Acta-Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease, Elsevier, 2020, 1866 (6), pp.165746. ⟨10.1016/j.bbadis.2020.165746⟩
Biochimica et Biophysica Acta-Molecular Basis of Disease, 2020, 1866 (6), pp.165746. ⟨10.1016/j.bbadis.2020.165746⟩

International audience; In the mitochondria of healthy cells, Apoptosis-Inducing factor (AIF) is required for the optimal functioning of the respiratory chain machinery, mitochondrial integrity, cell survival, and proliferation. In all analysed speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd687fc35ce96464acdae42ddba86de
http://orbilu.uni.lu/handle/10993/54782