Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Ruaidhri Jackson"'
Autor:
Hao Xu, Theodora Agalioti, Jun Zhao, Babett Steglich, Ramez Wahib, Maria Carolina Amezcua Vesely, Piotr Bielecki, Will Bailis, Ruaidhri Jackson, Daniel Perez, Jakob Izbicki, Paula Licona-Limón, Vesa Kaartinen, Jens Geginat, Enric Esplugues, Eva Tolosa, Samuel Huber, Richard A. Flavell, Nicola Gagliani
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
CD4+ T helper cells producing IL-17A (TH17 cells) can take on pathogenic or anti-inflammatory functions in context-specific manners. Here the authors show that the anti-inflammatory fate of TH17 cells contributes, via TGF-β signaling and induction o
Externí odkaz:
https://doaj.org/article/fd3bdc3cbb8644b4bdee048b5254c9a1
Autor:
Fiachra Humphries, Ronan Bergin, Ruaidhri Jackson, Nezira Delagic, Bingwei Wang, Shuo Yang, Alice V. Dubois, Rebecca J. Ingram, Paul N. Moynagh
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The NLRP3 inflammasome is important for inducing IL-1β and IL-18 inflammatory responses. Here the authors show, by generating and characterizing Peli2 deficient mice and immune cells, that an E3 ubiquitin ligase Pellino2 promotes inflammasome primin
Externí odkaz:
https://doaj.org/article/b58516ad7891424abe4c474bec6c5209
Autor:
Jun Wang, K. Patricia Hartmann, Connor E. Rosen, Richard A. Flavell, Marcus Bosenberg, Suzanne Fischer, Orr-El Weizman, Ruaidhri Jackson, Aaron M. Ring, Ting Zhou, William Damsky, Miguel F. Sanmamed, Meaghan K. McGeary
Publikováno v:
Nature
Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer, but they have only modest efficacy and limited tolerability1,2. In an effort to identify alternative cytokine pathways for immunotherapy, w
Autor:
Ruaidhri Jackson, Ariel Jaffe, Esen Sefik, Yuval Kluger, Richard A. Flavell, Ofir Lindenbaum, Henry Li, Xiuyuan Cheng, Jun Zhao
Publikováno v:
Proc Natl Acad Sci U S A
Comprehensive and accurate comparisons of transcriptomic distributions of cells from samples taken from two different biological states, such as healthy versus diseased individuals, are an emerging challenge in single-cell RNA sequencing (scRNA-seq)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d28202b7da77b0178c26b612f918c1b
https://europepmc.org/articles/PMC8179149/
https://europepmc.org/articles/PMC8179149/
Autor:
Roberto R. Ricardo-Gonzalez, Leif S. Ludwig, Georg Gasteiger, Holly R. Steach, Lina Kroehling, Maria Carolina Amezcua Vesely, Monika S. Kowalczyk, Autumn G. York, Mathias H. Skadow, Richard M. Locksley, Ruaidhri Jackson, Piotr Bielecki, Caroline B. M. Porter, Heather M. McGee, Aviv Regev, Hao Xu, Michal Slyper, Samantha J. Riesenfeld, Danielle Dionne, Will Bailis, Amanda J. Kedaigle, Elena Christian, Abigail Jarret, Richard A. Flavell, Elena Torlai Triglia, Paula Licona-Limón, Liming Tao, Mi Lian, Nicola Gagliani, Christoph Muus, Parastou Yaghoubi, Jan-Christian Hütter
Publikováno v:
Nature, vol 592, iss 7852
Nature
Nature
Tissue-resident innate lymphoid cells (ILCs) help sustain barrier function and respond to local signals. ILCs are traditionally classified as ILC1, ILC2 or ILC3 on the basis of their expression of specific transcription factors and cytokines1. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84e4925bc69bf051396bee0fdabe30e
https://escholarship.org/uc/item/4cc9s2xz
https://escholarship.org/uc/item/4cc9s2xz
Autor:
Mathias H. Skadow, Angel G. Solis, Abigail Jarret, J Richard Brewer, Alexandra Khitun, Holly R. Steach, Omair Khan, Will Bailis, Richard A. Flavell, Autumn G. York, Lina Kroehling, Ruaidhri Jackson, Christian C. D. Harman, Piotr Bielecki, Lelina Chang, Coco Duizer, Sarah A. Slavoff
Publikováno v:
Nature
The annotation of the mammalian protein coding genome is incomplete. Arbitrary open reading frame (ORF) size restriction and the absolute requirement for a methionine codon as the sole initiator of translation, have constrained identification of pote
Autor:
Justin A. Shyer, Rihao Qu, Yuval Kluger, Jorge Henao-Mejia, Ruaidhri Jackson, John L. Rinn, Jun Zhao, Loyal A. Goff, Adam Williams, Louisa Hill, Holly R. Steach, Christian C. D. Harman, Will Bailis, Richard A. Flavell
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Haematopoiesis relies on tightly controlled gene expression patterns as development proceeds through a series of progenitors. While the regulation of hematopoietic development has been well studied, the role of noncoding elements in this critical pro
Autor:
Chenbo Ding, Qiang Zou, Manolis Roulis, Hua-Bing Li, Bing Su, Zheng Wei, Jing Zhou, Yimeng Gao, Qiang Xia, Richard A. Flavell, Hao Xu, Esen Sefik, Abigail Jarret, Ruaidhri Jackson, Mathias H. Skadow, Rihao Qu, Zhibin Yu, Zhinan Yin
γδ T cells are abundant T cell population at the mucosa and are important in providing immune surveillance as well as maintaining tissue homeostasis. However, despite γδ T cells origin in thymus, detailed mechanisms regulating γδ T cell develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6514eee996a5af5fff4a82b5175b1f7d
https://doi.org/10.21203/rs.3.rs-79739/v1
https://doi.org/10.21203/rs.3.rs-79739/v1
Autor:
Esen Sefik, Xiaodong Jiang, Christian C. D. Harman, Jun Siong Low, Richard A. Flavell, Yagmur Farsakoglu, Maria Carolina Amezcua Vesely, Susan M. Kaech, Justin A. Shyer, Ruaidhri Jackson, Joseph B. Kelly, Linda S. Cauley
Publikováno v:
The Journal of Experimental Medicine
Low et al. compare the reactivation of memory CD8+ T cells resident in the lung or draining lymph node after a secondary influenza infection and find that memory T cells in the different anatomical locations have unique reactivation mechanics in term
Publikováno v:
Neurogastroenterol Motil
Background Commonly used methods to measure whole gut transit time in rodents have yet to combine high sensitivity, objectivity, and automation. We have developed a novel method using oral gavage of non-toxic fluorescent dye particles and their detec