Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ruaa Al-qazazi"'
Publikováno v:
Cells, Vol 12, Iss 21, p 2528 (2023)
DNA methylation is an epigenetic mechanism that regulates gene expression without altering gene sequences in health and disease. DNA methyltransferases (DNMTs) are enzymes responsible for DNA methylation, and their dysregulation is both a pathogenic
Externí odkaz:
https://doaj.org/article/1b5a843719ae49199b46664b35133c85
Autor:
Stephen L. Archer, Asish Dasgupta, Kuang-Hueih Chen, Danchen Wu, Kaushal Baid, John E. Mamatis, Victoria Gonzalez, Austin Read, Rachel ET. Bentley, Ashley Y. Martin, Jeffrey D. Mewburn, Kimberly J. Dunham-Snary, Gerald A. Evans, Gary Levy, Oliver Jones, Ruaa Al-Qazazi, Brooke Ring, Elahe Alizadeh, Charles CT. Hindmarch, Jenna Rossi, Patricia DA. Lima, Darryl Falzarano, Arinjay Banerjee, Che C. Colpitts
Publikováno v:
Redox Biology, Vol 58, Iss , Pp 102508- (2022)
Rationale: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 pneumonia. We hypothesize that SARS-CoV-2 causes alveolar injury and hypoxemia by damaging mitochondria in airway epithelial cells (AEC) and pulmonary artery smoo
Externí odkaz:
https://doaj.org/article/e159da1d54f348208fca210ce85dc53f
Autor:
Charles Colin Thomas Hindmarch, Lian Tian, Ping Yu Xiong, Francois Potus, Rachel Emily Teresa Bentley, Ruaa Al-Qazazi, Kurt W. Prins, Stephen L. Archer
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Aim: Pulmonary arterial hypertension (PAH) is an obstructive pulmonary vasculopathy that results in death from right ventricular failure (RVF). There is limited understanding of the molecular mechanisms of RVF in PAH.Methods: In a PAH-RVF model induc
Externí odkaz:
https://doaj.org/article/61645dbb02e24793bfcfd02ab8b072b2
Autor:
Kimberly J. Dunham-Snary, Bas GJ. Surewaard, Jeffrey D. Mewburn, Rachel ET. Bentley, Ashley Y. Martin, Oliver Jones, Ruaa Al-Qazazi, Patricia AD. Lima, Paul Kubes, Stephen L. Archer
Publikováno v:
Redox Biology, Vol 49, Iss , Pp 102225- (2022)
Background: Neutrophils play a role in innate immunity and are critical for clearance of Staphylococcus aureus. Current understanding of neutrophil bactericidal effects is that NADPH oxidase produces reactive oxygen species (ROS), mediating bacterial
Externí odkaz:
https://doaj.org/article/c6180755b5904ae7b1e5168555395369
Autor:
Sasha Z. Prisco, Lauren Rose, Francois Potus, Lian Tian, Danchen Wu, Lynn Hartweck, Ruaa Al-Qazazi, Monica Neuber-Hess, Megan Eklund, Steven Hsu, Thenappan Thenappan, Stephen L. Archer, Kurt W. Prins
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7278 (2020)
The hexosamine biosynthetic pathway (HBP) converts glucose to uridine-diphosphate-N-acetylglucosamine, which, when added to serines or threonines, modulates protein function through protein O-GlcNAcylation. Glutamine-fructose-6-phosphate amidotransfe
Externí odkaz:
https://doaj.org/article/3d3a8833186743b3b652e0c4b8189161
Autor:
Austin Read, Danchen Wu, Stephen L. Archer, Kuang-Hueih Chen, Asish Dasgupta, Jeffrey Mewburn, Mehras Motamed, Elahe Alizadeh, Kimberly J. Dunham-Snary, Lian Tian, Ruaa Al-qazazi, Rachel Bentley
Publikováno v:
Free Radic Biol Med
The homeostatic oxygen sensing system (HOSS) optimizes systemic oxygen delivery. Specialized tissues utilize a conserved mitochondrial sensor, often involving NDUFS2 in complex I of the mitochondrial electron transport chain, as a site of pO(2)-respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ed06ba00a7d3e1e683206c52f101e7
https://doi.org/10.1016/j.freeradbiomed.2020.12.452
https://doi.org/10.1016/j.freeradbiomed.2020.12.452
Autor:
Ruaa Al-Qazazi, Patricia D. A. Lima, Sasha Z. Prisco, Francois Potus, Asish Dasgupta, Kuang-Hueih Chen, Lian Tian, Rachel E. T. Bentley, Jeff Mewburn, Ashley Y. Martin, Danchen Wu, Oliver Jones, Donald H. Maurice, Sebastien Bonnet, Steeve Provencher, Kurt W. Prins, Stephen L. Archer
Publikováno v:
American journal of respiratory and critical care medicine. 206(5)
Rationale: Pulmonary arterial hypertension (PAH) often results in death from right ventricular failure (RVF). NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3)-macrophage activation may promote RVF in PAH. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0c4693362c46c46100c6dbdf2f16d4
https://pubmed.ncbi.nlm.nih.gov/35704289
https://pubmed.ncbi.nlm.nih.gov/35704289
Autor:
Kimberly J. Dunham-Snary, Bas GJ. Surewaard, Jeffrey D. Mewburn, Rachel ET. Bentley, Ashley Y. Martin, Oliver Jones, Ruaa Al-Qazazi, Patricia AD. Lima, Paul Kubes, Stephen L. Archer
Publikováno v:
Redox Biology
Redox Biology, Vol 49, Iss, Pp 102225-(2022)
Redox Biology, Vol 49, Iss, Pp 102225-(2022)
Background Neutrophils play a role in innate immunity and are critical for clearance of Staphylococcus aureus. Current understanding of neutrophil bactericidal effects is that NADPH oxidase produces reactive oxygen species (ROS), mediating bacterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d90d6ef589c6b0a6453c397c7178d51
https://pubmed.ncbi.nlm.nih.gov/34959099
https://pubmed.ncbi.nlm.nih.gov/34959099
Autor:
Patricia D.A. Lima, François Potus, Stephen L. Archer, Ruaa Al-qazazi, Sébastien Bonnet, Kuang-Hueih Chen, Asish Dasgupta, Lian Tian, Danchen Wu, Oliver Jones, Jeffrey Mewburn
Publikováno v:
The FASEB Journal. 35
Impaired mitochondrial fusion, due in part to decreased mitofusin 2 (Mfn2) expression, contributes to unrestricted cell proliferation and apoptosis-resistance in hyperproliferative diseases like pulmonary arterial hypertension (PAH) and non-small cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519b42a6c33b33d3a4c423948549b05a
https://doi.org/10.1096/fj.202100361r
https://doi.org/10.1096/fj.202100361r
Autor:
Kurt W. Prins, Lauren Rose, M. Neuber-Hess, François Potus, Lian Tian, Stephen L. Archer, Ruaa Al-qazazi, Sasha Z. Prisco, Thenappan Thenappan, Lynn M. Hartweck, Danchen Wu, Megan Eklund, Steven Hsu
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 19
International Journal of Molecular Sciences, Vol 21, Iss 7278, p 7278 (2020)
Volume 21
Issue 19
International Journal of Molecular Sciences, Vol 21, Iss 7278, p 7278 (2020)
The hexosamine biosynthetic pathway (HBP) converts glucose to uridine-diphosphate-N-acetylglucosamine, which, when added to serines or threonines, modulates protein function through protein O-GlcNAcylation. Glutamine-fructose-6-phosphate amidotransfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57596be5b26b10a0479fca5982ebad8