Výsledky vyhledávání - "Rua'a A. Al-Aqtash"

Discovery of New Phosphoinositide 3-kinase Delta (PI3Kδ) Inhibitors via Virtual Screening using Crystallography-derived Pharmacophore Modelling and QSAR Analysis

Autor: Rua'a A. Al-Aqtash, Mahmoud A. Al-Sha’er, Mutasem O. Taha

Publikováno v: Medicinal Chemistry. 15:588-601

Background: PI3Kδ is predominantly expressed in hematopoietic cells and participates in the activation of leukocytes. PI3Kδ inhibition is a promising approach for treating inflammatory diseases and leukocyte malignancies. Accordingly, we decided to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908f4c283e5eb253248098635dd57096
https://doi.org/10.2174/1573406415666190222125333

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L-Citrulline Supplementation Increases Plasma Nitric Oxide Levels and Reduces Arginase Activity in Patients With Type 2 Diabetes

Autor: Mohammad H Hamdan, Munir N. Gharaibeh, Rua’a A. Al-Aqtash, Alia Shatanawi, Munther S. Momani

Publikováno v: Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 11 (2020)

Type 2 diabetes mellitus (T2DM) is becoming a major contributor to cardiovascular disease. One of the early signs of T2DM associated cardiovascular events is the development of vascular dysfunction. This dysfunction has been implicated in increasing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba80c3ddec5a55ab88d1674555959ae5
http://europepmc.org/articles/PMC7783447

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Ligand-based computational modelling of platelet-derived growth factor beta receptor leading to new angiogenesis inhibitory leads

Autor: Hana Hammad, Malek Zihlif, Zeyad D. Nassar, Rua’a A. Al-Aqtash, Mutasem O. Taha, Jehad Al Meliti

Publikováno v: Computational Biology and Chemistry. 71:170-179

Platelet derived growth factor beta receptor (PDGFR- β) plays an important role in angiogenesis. PDGFR-β expression is correlated with increased vascularity and maturation of blood vessels in cancer. Pharmacophore modeling and quantitative structur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f305be29c6911576c1a281884597c2d0
https://doi.org/10.1016/j.compbiolchem.2017.10.003

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Computational modeling of the bat HKU4 coronavirus 3CL pro inhibitors as a tool for the development of antivirals against the emerging M iddle E ast respiratory syndrome ( MERS ) coronavirus

Autor: Mutasem O. Taha, Rua’a A. Al-Aqtash, Andrew D. Mesecar, Brandon J. Anson, Areej Abuhammad

Publikováno v: Journal of Molecular Recognition. 30

The Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging virus that poses a major challenge to clinical management. The 3C-like protease (3CLpro) is essential for viral replication and thus represents a potential target for antivira

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25547ec6d44b48191bd902645d08f293
https://doi.org/10.1002/jmr.2644

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