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Autor:
RuJu Chian, Diana Linnekin, Leonie K. Ashman, Alla Danilkovitch-Miagkova, Sonia Young, Lars Rönnstrand, Edward J. Leonard, Petranel Ferrao
Publikováno v:
Blood. 98(5)
Stem cell factor (SCF) binds the receptor tyrosine kinase c-Kit and is critical for normal hematopoiesis. Substitution of valine for aspartic acid 816 (D816V) constitutively actives human c-Kit, and this mutation is found in patients with mastocytosi