Výsledky vyhledávání - "Ru-Hao Liang"

Akademický článek

Synthesis and biological evaluation of C-4 substituted phenoxazine-bearing hydroxamic acids with potent class II histone deacetylase inhibitory activities

Autor: Jung-Chun Chu, Hui-Ju Tseng, Sung-Bau Lee, Kai-Cheng Hsu, Ling-Wei Hsin, Ru-Hao Liang, Tony Eight Lin, Nain-Chu Gao, Liang-Chieh Chen, Wan-Hsun Lu, Andrew H.-J Wang, Wei-Jan Huang

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

Class II histone deacetylases (HDACs) are considered as potential targets to treat Alzheimer’s disease (AD). Previously, C-3 substituted phenothiazine-containing compounds with class II HDAC-inhibiting activities was found to promote neurite outgro

Externí odkaz: https://doaj.org/article/7b58580986544041963eeb2da4256825

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Bis(chloroacetamidino)-Derived Heteroarene-Fused Anthraquinones Bind to and Cause Proteasomal Degradation of tNOX, Leading to c-Flip Downregulation and Apoptosis in Oral Cancer Cells

Autor: Jeng Shiun Chang, Chien-Yu Chen, Alexander S. Tikhomirov, Atikul Islam, Ru-Hao Liang, Chia-Wei Weng, Wei-Hou Wu, Andrey E. Shchekotikhin, Pin Ju Chueh

Publikováno v: Cancers; Volume 14; Issue 19; Pages: 4719

Anthraquinone-based intercalating compounds, namely doxorubicin and mitoxantrone, have been used clinically based on their capacity to bind DNA and induce DNA damage. However, their applications have been limited by side effects and drug resistance.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d972b906e636533af406900cac6baf

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Antibiotic heliomycin and its water-soluble 4-aminomethylated derivative provoke cell death in T24 bladder cancer cells by targeting sirtuin 1 (SIRT1)

Autor: Ming Hung, Lin, Atikul, Islam, Yen-Hui, Liu, Chia-Wei, Weng, Jun-Han, Zhan, Ru-Hao, Liang, Alexander S, Tikhomirov, Andrey E, Shchekotikhin, Pin Ju, Chueh

Publikováno v: Am J Cancer Res

Bladder cancer is one of the most frequent cancers among males, and a poor survival rate reflects problems with aggressiveness and chemo-resistance. Accumulating evidence indicates that SIRT1 is involved in bladder cancer tumorigenesis and is positiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f7b5400cca8bdf6c6c36dde036949214
https://pubmed.ncbi.nlm.nih.gov/35411221

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