Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Ru Liu‐Bryan"'
Autor:
Concepcion Sanchez, Anaamika Campeau, Ru Liu-Bryan, Ted R. Mikuls, James R. O’Dell, David J. Gonzalez, Robert Terkeltaub
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Urate-lowering treatment (ULT) to target with xanthine oxidase inhibitors (XOIs) paradoxically causes early increase in gouty arthritis flares. Because delayed reduction in flare burden is mechanistically unclear, we tested for ULT inflammat
Externí odkaz:
https://doaj.org/article/e349f9cade8a437bae5fe3b49312ee3e
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103030- (2024)
Summary: Gout is caused by the deposition of monosodium urate crystals (MSUc) in the joints, triggering a unique inflammatory and metabolic response in macrophages. Here, we present a protocol to generate MSUc for in vitro and in vivo studies in mous
Externí odkaz:
https://doaj.org/article/748a4bdf7ee9431d95b55eaac584eca0
Autor:
Monica Guma, Benyamin Dadpey, Roxana Coras, Ted R. Mikuls, Bartlett Hamilton, Oswald Quehenberger, Hilda Thorisdottir, David Bittleman, Kimberly Lauro, Shannon M. Reilly, Ru Liu-Bryan, Robert Terkeltaub
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-13 (2022)
Abstract Objective Linked metabolic and cardiovascular comorbidities are prevalent in hyperuricemia and gout. For mechanistic insight into impact on inflammatory processes and cardiometabolic risk factors of xanthine oxidase inhibitor urate-lowering
Externí odkaz:
https://doaj.org/article/2e001f3b06a94a069b0f462242812c21
Autor:
Isidoro Cobo, Anyan Cheng, Jessica Murillo-Saich, Roxana Coras, Alyssa Torres, Yohei Abe, Addison J. Lana, Johannes Schlachetzki, Ru Liu-Bryan, Robert Terkeltaub, Elsa Sanchez-Lopez, Christopher K. Glass, Monica Guma
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110489- (2022)
Summary: Monosodium urate crystals (MSUc) induce inflammation in vivo without prior priming, raising the possibility of an initial cell-autonomous phase. Here, using genome-wide transcriptomic analysis and biochemical assays, we demonstrate that MSUc
Externí odkaz:
https://doaj.org/article/59ac06773fa54dd1820f6bbb11d5a0f0
Autor:
Xiangzhao Ai, Yaou Duan, Qiangzhe Zhang, Derrick Sun, Ronnie H. Fang, Ru Liu‐Bryan, Weiwei Gao, Liangfang Zhang
Publikováno v:
Bioengineering & Translational Medicine, Vol 6, Iss 1, Pp n/a-n/a (2021)
Abstract Current drug delivery approaches for the treatment of cartilage disorders such as osteoarthritis (OA) remain inadequate to achieve sufficient drug penetration and retention in the dense cartilage matrix. Herein, we synthesize sub‐30 nm lip
Externí odkaz:
https://doaj.org/article/eb262d4eafab4ae4b281c64779be6d97
Autor:
Charles McWherter, Yun-Jung Choi, Ramon L. Serrano, Sushil K. Mahata, Robert Terkeltaub, Ru Liu-Bryan
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-11 (2018)
Abstract Background Arhalofenate acid, the active acid form of arhalofenate, is a non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand, with uricosuric activity via URAT1 inhibition. Phase II studies revealed decreased acute arth
Externí odkaz:
https://doaj.org/article/d6553b490e6f4c16870ac89284cdd33e
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140452 (2015)
AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase critically involved in the regulation of cellular energy homeostasis. It is a central regulator of both lipid and glucose metabolism. Many studies have suggested that AMPK activ
Externí odkaz:
https://doaj.org/article/e254eb9aa7dd4910ad433cca1e4d93d5
Autor:
Khaled Elsaid, Tony R. Merriman, Leigh‐Ana Rossitto, Ru Liu‐Bryan, Jacob Karsh, Amanda Phipps‐Green, Gregory D. Jay, Sandy Elsayed, Marwa Qadri, Marin Miner, Murray Cadzow, Talia J. Dambruoso, Tannin A. Schmidt, Nicola Dalbeth, Ashika Chhana, Jennifer Höglund, Majid Ghassemian, Anaamika Campeau, Nancy Maltez, Niclas G. Karlsson, David J. Gonzalez, Robert Terkeltaub
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.).
In gout, hyperuricemia promotes urate crystal deposition that stimulates the NLRP3 inflammasome and IL-1β-mediated arthritis. Incident gout without background hyperuricemia is rarely reported. To identify hyperuricemia-independent mechanisms driving
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1f1d1e711df58df24eaa422cc0ff478
https://pubmed.ncbi.nlm.nih.gov/36457235
https://pubmed.ncbi.nlm.nih.gov/36457235
Targeting CD38 to suppress osteoarthritis development and associated pain after joint injury in mice
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.).
To determine the role of CD38, which can function as an enzyme to degrade nicotinamide adenosine dinucleotide (NADHuman knee cartilage from normal and OA donors were examined for CD38 expression. Approaches of "gain-of-function" through overexpressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82df482e84ab30509679527429b6cbd4
https://pubmed.ncbi.nlm.nih.gov/36103412
https://pubmed.ncbi.nlm.nih.gov/36103412
Autor:
Tyler A. U. Hilsabeck, Ru Liu-Bryan, Tracy Guo, Kenneth A. Wilson, Neelanjan Bose, Daniel Raftery, Jennifer N. Beck, Sven Lang, Kelly Jin, Christopher S. Nelson, Tal Oron, Marshall Stoller, Daniel Promislow, Rachel B. Brem, Robert Terkeltaub, Pankaj Kapahi
Publikováno v:
GeroScience, vol 44, iss 4
GeroScience
GeroScience
Elevated serum urate (hyperuricemia) promotes crystalline monosodium urate tissue deposits and gout, with associated inflammation and increased mortality. To identify modifiers of uric acid pathologies, we performed a fly Genome-Wide Association Stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4657fbfcc42b6acd5163051fb15ec7
https://escholarship.org/uc/item/20c3d830
https://escholarship.org/uc/item/20c3d830
