Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Ru Chih C. Huang"'
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 11, Pp 9262-9283 (2023)
Specificity protein 1 (SP1), hypoxia-inducible factor 1 (HIF-1), and MYC are important transcription factors (TFs). SP1, a constitutively expressed housekeeping gene, regulates diverse yet distinct biological activities; MYC is a master regulator of
Externí odkaz:
https://doaj.org/article/8df6ec17484a497db0ed0dd6d02353a0
Autor:
Kotohiko Kimura, Jong Ho Chun, Yu-Ling Lin, Yu-Chuan Liang, Tiffany L. B. Jackson, Ru Chih C. Huang
Publikováno v:
PLoS ONE, Vol 18, Iss 5 (2023)
Tetra-O-methyl-nordihydroguaiaretic acid (terameprocol; M4N), a global transcription inhibitor, in combination with a second anticancer drug induces strong tumoricidal activity and has the ability to suppress energy metabolism in cultured cancer cell
Externí odkaz:
https://doaj.org/article/19ca8f15c5e74974b8e7bc647814c826
Autor:
Yu-Chuan Liang, DVM, Yu-Ling Lin, PhD, Ru Chih C. Huang, PhD, Tiffany Jackson, PhD, Kotohiko Kimura, MD/PhD, Jong Ho Chun, MD/PhD
Tetra-O-methyl-nordihydroguaiaretic acid (terameprocol; M4N), a global transcription inhibitor, in combination with a second anticancer drug induces strong tumoricidal activity and has the ability to suppress energy metabolism in cultured cancer cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb3348546abd60cd7512f8d628f22aed
Autor:
Kotohiko Kimura, Ru Chih C Huang
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148685 (2016)
The ability of Tetra-O-methyl nordihydroguaiaretic acid (M4N) to induce rapid cell death in combination with Etoposide, Rapamycin, or UCN-01 was examined in LNCaP cells, both in cell culture and animal experiments. Mice treated with M4N drug combinat
Externí odkaz:
https://doaj.org/article/a4c788172fd542ce8d650d4476218e43
Publikováno v:
Journal of Traditional and Complementary Medicine, Vol 5, Iss 3, Pp 119-126 (2015)
Journal of Traditional and Complementary Medicine
Journal of Traditional and Complementary Medicine
The medicinal properties of the most successful plant in the deserts of the western hemisphere, the creosote bush (Larrea tridentata), are evidenced by the long traditional usage of the plants by the Native Americans Indian tribes in Southwestern Nor
Autor:
Ming Hua Hsu, Ru Chih C. Huang, Jackson Tiffany, Chia-Ching Chang, Kuang-Wen Liao, Cheng Hao Hsieh, Nu Man Tsai, Yu Ling Lin, Hsin Yi Wu, Jung Chang, David E. Mold, Shu Yi Ho
Publikováno v:
Proceedings of the National Academy of Sciences. 113
Cancer progression is associated with the development of antitumor autoantibodies in patients’ sera. Although passive treatment with antitumor antibodies has exhibited remarkable therapeutic efficacy, inhibitory effects on tumor progression by endo
Publikováno v:
European Journal of Organic Chemistry. 2012:4684-4688
The first total syntheses of oresbiusin A in the (+)-, (–)-, and (±)-forms were accomplished in five steps with overall yields of ca. 70 %. The key intermediates with optical activity were generated through a Sharpless asymmetric dihydroxylation r
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1884-1888
Reaction of nordihydroguaiaretic acid with various alkyl chloride, 1-piperidinecarbonyl chloride, methyl chloroformate, or 1,1'-carbonyldiimidazole under alkaline conditions produced the corresponding phenol ethers, carbamates and carbonates, respect
Autor:
Yu-Chuan Liang, David E. Mold, Ting-Chao Chou, Chih-Chuan Chang, Chien-Fu Lin, Yuan C. Lee, Ru Chih C. Huang, Athena Klutz, Chuan-I Hsu
Publikováno v:
Cancer Chemotherapy and Pharmacology. 58:640-653
Purpose: Multidrug resistance (MDR) continues to be a major obstacle for successful anticancer therapy. One of the principal factors implicated in MDR is the over expression of P-glycoprotein (Pgp), the product of the MDR1 gene. Methods: Here we expl
Autor:
Yousun Chung, Ru Chih C. Huang, Elaine Lin, Chih-Chuan Chang, Yu-Chuan Liang, Richard Park, Ryan A. Henry, David E. Mold
Publikováno v:
Clinical Cancer Research. 11:4601-4609
Purpose: We have previously shown that the transcriptional inhibitor tetra-O-methyl nordihydroguaiaretic acid (M4N) induces growth arrest in tumor cells and exhibits tumoricidal activity when injected intratumorally into tumor cell explants in mice.