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Broadly applicable TCR-based therapy for multiple myeloma targeting the immunoglobulin J chain

Autor: Meeuwsen, M.H., Wouters, A.K., Wachsmann, T.L.A., Hagedoorn, R.S., Kester, M.G.D., Remst, D.F.G., Steen, D.M. van der, Ru, A.H. de, Hees, E.P. van, Kremer, M., Griffioen, M., Veelen, P.A. van, Falkenburg, J.H.F., Heemskerk, M.H.M.

Publikováno v: Journal of Hematology and Oncology, 16(1). BMC

Background The immunoglobulin J chain (Jchain) is highly expressed in the majority of multiple myeloma (MM), and Jchain-derived peptides presented in HLA molecules may be suitable antigens for T-cell therapy of MM. Methods Using immunopeptidomics, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1e2f6ddb1f105d12c9b23397f7c32f
https://doi.org/10.1186/s13045-023-01408-6

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The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling

Autor: Treffers, E.E., Tas, A., Scholte, F.E.M., Ru, A.H. de, Snijder, E.J., Veelen, P.A. van, Hemert, M.J. van

Publikováno v: PLoS Pathogens, 19(2). PUBLIC LIBRARY SCIENCE

Chikungunya virus (CHIKV) is a reemerging alphavirus. Since 2005, it has infected millions of people during outbreaks in Africa, Asia, and South/Central America. CHIKV replication depends on host cell factors at many levels and is expected to have a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0057419cf4ec9ba8a1e7a7c457472c
https://hdl.handle.net/1887/3593845

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Cancer-specific T helper shared and neo-epitopes uncovered by expression of the MHC class II master regulator CIITA

Autor: Hos, B.J., Tondini, E., Camps, M.G.M., Rademaker, W., Bulk, J. van den, Ruano, D., Janssen, G.M.C., Ru, A.H. de, Elsen, P.J. van den, Miranda, N.F.C.C. de, Veelen, P.A. van, Ossendorp, F.

Publikováno v: Cell Reports, 41(2). ScienceDirect
Cell Reports, 41(2). CELL PRESS

We report an approach to identify tumor-specific CD4+ T cell neo-epitopes of both mouse and human cancer cells by analysis of major histocompatibility complex (MHC) class II-eluted natural peptides. MHC class II -presented peptide sequences are ident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa97bc3ea64d8f5ba234e33fa12dfdfb
https://hdl.handle.net/1887/3593843

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Quantitative proteomics of small numbers of closely-related cells: Selection of the optimal method for a clinical setting

Publikováno v: Frontiers in Medicine, 9:997305. Frontiers Media S.A.
Frontiers in Medicine, 9. FRONTIERS MEDIA SA

Mass spectrometry (MS)-based proteomics profiling has undoubtedly increased the knowledge about cellular processes and functions. However, its applicability for paucicellular sample analyses is currently limited. Although new approaches have been dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897e1671943173654f52c0f362a14c8f
https://pure.eur.nl/en/publications/148825fb-7f80-40d9-842f-9f9986554acb

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PTX3 structure determination using a hybrid cryoelectron microscopy and AlphaFold approach offers insights into ligand binding and complement activation

Autor: Noone, D.P., Dijkstra, D.J., Klugt, T.T. van der, Veelen, P.A. van, Ru, A.H. de, Hensbergen, P.J., Trouw, L.A., Sharp, T.H.

Publikováno v: Proceedings of the National Academy of Sciences, 119(33). NATL ACAD SCIENCES

Pattern recognition molecules (PRMs) form an important part of innate immunity, where they facilitate the response to infections and damage by triggering processes such as inflammation. The pentraxin family of soluble PRMs comprises long and short pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381b42d254864cf37725346a78821e6f
https://doi.org/10.1073/pnas.2208144119

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A library of cancer testis specific T cell receptors for T cell receptor gene therapy

Autor: Rooij, M.A.J. de, Remst, D.F.G., Steen, D.M. van der, Wouters, A.K., Hagedoorn, R.S., Kester, M.G.D., Meeuwsen, M.H., Wachsmann, T.L.A., Ru, A.H. de, Veelen, P.A. van, Verdegaal, E.M.E., Falkenburg, J.H.F., Heemskerk, M.H.M.

Publikováno v: Molecular Therapy-Oncolytics, 28, 1-14. CELL PRESS

To increase the number of cancer patients that can be treated with T cell receptor (TCR) gene therapy, we aimed to identify a set of high-affinity cancer-specific TCRs targeting different melanoma-associated antigens (MAGEs). In this study, pep-tides

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2124913943b66063e6806aeaf7774d
https://pubmed.ncbi.nlm.nih.gov/36589698

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