An eco-friendly HPLC-UV method for the determination of risedronate in its bulk and tablet dosage form with application to content uniformity, dissolution and stability testing

Autor: Rania M. El-Gamal, Mehnaz Kamal, Moustapha E. Moustapha

Publikováno v: Saudi Pharmaceutical Journal : SPJ
Saudi Pharmaceutical Journal, Vol 28, Iss 11, Pp 1301-1308 (2020)

Risedronate is a nitrogen-containing bisphosphonate for the treatment and prevention of postmenopausal osteoporosis. The current work aims to develop a novel green HPLC-UV method for the rapid analysis of risedronate sodium in bulk and tablet formula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db405a1006c6ceb48616cbd8e75bf0bf
http://europepmc.org/articles/PMC7679468

DIA-Based Proteomics Identifies IDH2 as a Targetable Regulator of Acquired Drug Resistance in Chronic Myeloid Leukemia

Autor: Wei Liu, Yaoting Sun, Weigang Ge, Fangfei Zhang, Lin Gan, Yi Zhu, Tiannan Guo, Kexin Liu

Publikováno v: Molecular & Cellular Proteomics : MCP

Drug resistance is a critical obstacle to effective treatment in patients with chronic myeloid leukemia. To understand the underlying resistance mechanisms in response to imatinib mesylate (IMA) and adriamycin (ADR), the parental K562 cells were trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3bdf625e96948f348e1492f9567a2e8
http://europepmc.org/articles/PMC8800142

The C-Mannosylome of Human Induced Pluripotent Stem Cells Implies a Role for ADAMTS16 C-Mannosylation in Eye Development

Autor: Aleksandra Shcherbakova, Karsten Cirksena, Joachim Wittbrodt, Falk F. R. Buettner, Roman Sakson, Lars R. Jensen, Thomas Ruppert, Daniel Todt, Andreas W. Kuss, Alina Friedrich, Stefan Weiss, Hermann J. Hütte, Hans Bakker, Thomas Thumberger

Publikováno v: Molecular & Cellular Proteomics : MCP

C-mannosylation is a modification of tryptophan residues with a single mannose and can affect protein folding, secretion, and/or function. To date, only a few proteins have been demonstrated to be C-mannosylated, and studies that globally assess prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7dcfa5ab5c34fd0ed0c4709b4ea4419
https://pubmed.ncbi.nlm.nih.gov/33975020

The Role of Data-Independent Acquisition for Glycoproteomics

Autor: Sergey Y. Vakhrushev, Zilu Ye

Publikováno v: Ye, Z & Vakhrushev, S Y 2021, ' The Role of Data-Independent Acquisition for Glycoproteomics ', Molecular & Cellular Proteomics, vol. 20, 100042 . https://doi.org/10.1074/mcp.R120.002204
Molecular & Cellular Proteomics : MCP

Data-independent acquisition (DIA) is now an emerging method in bottom–up proteomics and capable of achieving deep proteome coverage and accurate label-free quantification. However, for post-translational modifications, such as glycosylation, DIA m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5faa061c69e45a6bf2901882d777e6df
https://curis.ku.dk/portal/da/publications/the-role-of-dataindependent-acquisition-for-glycoproteomics(db9c851d-2dc6-4054-886d-bdebd9658b20).html

Insight into chemical basis of traditional Chinese medicine based on the state-of-the-art techniques of liquid chromatography-mass spectrometry

Autor: Changliang Yao, De-An Guo, Yang Yu

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1469-1492 (2021)

Traditional Chinese medicine (TCM) has been an indispensable source of drugs for curing various human diseases. However, the inherent chemical diversity and complexity of TCM restricted the safety and efficacy of its usage. Over the past few decades,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e17b04c502a8079fb64055ca20456b6
https://pubmed.ncbi.nlm.nih.gov/34221863