HostSeq: a Canadian whole genome sequencing and clinical data resource

Autor: S Yoo, E Garg, LT Elliott, RJ Hung, AR Halevy, JD Brooks, SB Bull, F Gagnon, CMT Greenwood, JF Lawless, AD Paterson, L Sun, MH Zawati, J Lerner-Ellis, RJS Abraham, I Birol, G Bourque, J-M Garant, C Gosselin, J Li, J Whitney, B Thiruvahindrapuram, J-A Herbrick, M Lorenti, MS Reuter, OO Adeoye, S Liu, U Allen, FP Bernier, CM Biggs, AM Cheung, J Cowan, M Herridge, DM Maslove, BP Modi, V Mooser, SK Morris, M Ostrowski, RS Parekh, G Pfeffer, O Suchowersky, J Taher, J Upton, RL Warren, RSM Yeung, N Aziz, SE Turvey, BM Knoppers, M Lathrop, SJM Jones, SW Scherer, LJ Strug

Publikováno v: BMC Genomic Data, Vol 24, Iss 1, Pp 1-12 (2023)

Abstract HostSeq was launched in April 2020 as a national initiative to integrate whole genome sequencing data from 10,000 Canadians infected with SARS-CoV-2 with clinical information related to their disease experience. The mandate of HostSeq is to

Externí odkaz: https://doaj.org/article/8dd9330e73634673be15f3808eeffdfb

OP0332 Paediatric open-label clinical study of rituximab for the treatment of granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA)

Autor: Satyapal Rangaraj, J. Cooper, P.B. Lehane, Gavin Cleary, Pooneh Pordeli, Paul Brunetta, Ozgur Kasapcopur, Paul A. Brogan, Rsm Yeung

Publikováno v: FRIDAY, 15 JUNE 2018.

Background Rituximab in combination with glucocorticoids (GC) is approved to treat adult patients (pts) with GPA or MPA; however, limited data exist on the safety and efficacy of rituximab in paediatric pts with these potentially life- and organ-thre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae1e1cec0d094d2ad71e8133826c79f7
https://doi.org/10.1136/annrheumdis-2018-eular.2150

OP0122 Fine Mapping of the CHR 22Q13.1 Juvenile Idiopathic Arthritis Risk Locus

Autor: Leah C. Kottyan, Anne Hinks, Susan D. Thompson, Matthew T. Weirauch, Lucy R. Wedderburn, Sampath Prahalad, J.-P. Haas, Carl D. Langefeld, Ellen Nordal, L. Brungs, Marc Sudman, Miranda C. Marion, Wendy Thomson, J Cobb, B.E. Levy, Vibeke Videm, Halima Moncrieffe, K.A. Shams, Aditi Lele, John F. Bohnsack, Rsm Yeung, Marite Rygg

Publikováno v: Annals of the Rheumatic Diseases. 74:114.2-114

Background Juvenile Idiopathic Arthritis (JIA) patients have arthritis onset of unknown cause that lasts >6 weeks in the inflamed joints of children younger than 16 years. JIA is a complex genetic trait with established increased familial risk and ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d804cb3afe43e941205c999f986e0f8a
https://doi.org/10.1136/annrheumdis-2015-eular.5296

Enrichment of Rare Variants of Hemophagocytic Lymphohistiocytosis Genes in Systemic Juvenile Idiopathic Arthritis.

Autor: Correia Marques M; National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland., Rubin D; National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland., Shuldiner EG; National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland., Datta M; National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland., Schmitz E; National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland., Gutierrez Cruz G; National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland., Patt A; National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland., Bennett E; National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland., Grom A; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Foell D; University Hospital Muenster, Muenster, Germany., Gattorno M; IRCCS Istituto G. Gaslini, Genoa, Italy., Bohnsack J; University of Utah Eccles School of Medicine, Salt Lake City., Yeung RSM; University of Toronto, Toronto, Ontario, Canada., Prahalad S; Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia., Mellins E; Stanford University, Stanford, California., Anton J; Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain., Len CA; São Paulo Federal University, São Paulo, Brazil., Oliveira S; Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Woo P; University College London, London, United Kingdom., Ozen S; Hacettepe University, Ankara, Turkey., Deng Z; National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland., Ombrello MJ; National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland.

Publikováno v: Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2024 Oct; Vol. 76 (10), pp. 1566-1572. Date of Electronic Publication: 2024 Aug 09.

A decade of progress in juvenile idiopathic arthritis treatments and outcomes in Canada: results from ReACCh-Out and the CAPRI registry.

Autor: Nguyen K; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Barsalou J; Department of Pediatrics, Université de Montréal, Montréal, QC, Canada., Basodan D; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Batthish M; Department of Pediatrics, McMaster University, Hamilton, ON, Canada., Benseler SM; Department of Pediatrics, University of Calgary, Calgary, AB, Canada., Berard RA; Department of Pediatrics, Western University, London, ON, Canada., Blanchette N; Health Sciences North, Sudbury, ON, Canada., Boire G; Department of Pediatrics, Université de Sherbrooke, Sherbrooke, QC, Canada., Bolaria R; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Bruns A; Department of Pediatrics, Université de Sherbrooke, Sherbrooke, QC, Canada., Cabral DA; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Cameron B; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Campillo S; Department of Pediatrics, McGill University, Montreal, QC, Canada., Cellucci T; Department of Pediatrics, McMaster University, Hamilton, ON, Canada., Chan M; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Chédeville G; Department of Pediatrics, McGill University, Montreal, QC, Canada., Chetaille AL; Department of Pediatrics, CHU de Québec-Université Laval, Québec, Canada., Chhabra A; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Couture J; Department of Pediatrics, Université de Montréal, Montréal, QC, Canada., Dancey P; Department of Pediatrics, Memorial University, St. John's, NL, Canada., De Bruycker JJ; Department of Pediatrics, Université de Montréal, Montréal, QC, Canada., Demirkaya E; Department of Pediatrics, Western University, London, ON, Canada., Dhalla M; Department of Pediatrics, University of Calgary, Calgary, AB, Canada., Duffy CM; Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada., Feldman BM; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Feldman DE; Department of Pediatrics, Université de Montréal, Montréal, QC, Canada., Gerschman T; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Haddad E; Department of Pediatrics, Université de Montréal, Montréal, QC, Canada., Heale L; Department of Pediatrics, McMaster University, Hamilton, ON, Canada., Herrington J; Department of Pediatrics, McMaster University, Hamilton, ON, Canada., Houghton K; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Huber AM; Department of Pediatrics, Dalhousie University, Halifax, NS, Canada., Human A; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Johnson N; Department of Pediatrics, University of Calgary, Calgary, AB, Canada., Jurencak R; Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada., Lang B; Department of Pediatrics, Dalhousie University, Halifax, NS, Canada., Larché M; Department of Pediatrics, McMaster University, Hamilton, ON, Canada., Laxer RM; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., LeBlanc CM; Department of Pediatrics, McGill University, Montreal, QC, Canada., Lee JJY; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Levy DM; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Lim L; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Lim LSH; Department of Pediatrics, University of Manitoba, Winnipeg, MB, Canada., Luca N; Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada., McGrath T; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., McMillan T; Department of Pediatrics, University of Manitoba, Winnipeg, MB, Canada., Miettunen PM; Department of Pediatrics, University of Calgary, Calgary, AB, Canada., Morishita KA; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Ng HY; Department of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada., Oen K; Department of Pediatrics, University of Manitoba, Winnipeg, MB, Canada., Park J; Department of Pediatrics, Western University, London, ON, Canada., Petty RE; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Proulx-Gauthier JP; Department of Pediatrics, CHU de Québec-Université Laval, Québec, Canada., Ramsey S; Department of Pediatrics, Dalhousie University, Halifax, NS, Canada., Roth J; Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada., Rosenberg AM; Department of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada., Rozenblyum E; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Rumsey DG; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Schmeling H; Department of Pediatrics, University of Calgary, Calgary, AB, Canada., Schneider R; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Scuccimarri R; Department of Pediatrics, McGill University, Montreal, QC, Canada., Shiff NJ; Department of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada., Silverman E; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Soon G; Health Sciences North, Sudbury, ON, Canada.; North York General Hospital, North York, Toronto, ON, Canada., Spiegel L; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Stringer E; Department of Pediatrics, Dalhousie University, Halifax, NS, Canada., Tam H; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Tse SM; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Tucker LB; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Turvey S; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Twilt M; Department of Pediatrics, University of Calgary, Calgary, AB, Canada., Duffy KW; Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada., Yeung RSM; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Guzman J; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.

Publikováno v: Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2024 Sep 01; Vol. 63 (SI2), pp. SI173-SI179.