Zobrazeno 1 - 10
of 423
pro vyhledávání: '"Rsk2"'
Autor:
Suyeon Kim, Ki Wook Lee, Yongjin Yoo, Sang Hee Park, Ji Won Lee, Suhyun Jeon, Shaginyan Illia, Pooja Joshi, Hyun Woo Park, Han-En Lo, Jimin Seo, Yeonwoo Kim, Min Chang, Tae Jin Lee, Jong Bae Seo, Sung-Hak Kim, Carlo M. Croce, Inki Kim, Sung-Suk Suh, Young-Jun Jeon
Publikováno v:
Animal Cells and Systems, Vol 28, Iss 1, Pp 184-197 (2024)
ABSTRACTTumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has chemotherapeutic potential as a regulator of an extrinsic apoptotic ligand, but its effect as a drug is limited by innate and acquired resistance. Recent findings suggest tha
Externí odkaz:
https://doaj.org/article/f61b46f24f894d4e8a34249749f4f54c
Autor:
Dohyun Jeung, Ga-Eun Lee, Weidong Chen, Jiin Byun, Soo-Bin Nam, You-Min Park, Hye Suk Lee, Han Chang Kang, Joo Young Lee, Kwang Dong Kim, Young-Soo Hong, Cheol-Jung Lee, Dae Joon Kim, Yong-Yeon Cho
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Although previous studies have examined the signaling pathway involved in melanogenesis through which ultraviolet (UV) or α-melanocyte-stimulating hormones (α-MSH) stimuli act as key inducers to produce melanin at the stratum basal layer o
Externí odkaz:
https://doaj.org/article/0ac73f9cafcc4c07b0467d71513f83bd
Autor:
Jaspreet Kalra, Mykhaylo Artamonov, Hua Wang, Aaron Franke, Zaneta Markowska, Li Jin, Zygmunt S. Derewenda, Ramon J. Ayon, Avril Somlyo
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Phosphorylation of smooth muscle (SM) myosin regulatory light chain (RLC20) is a critical switch leading to SM contraction. The canonical view held that only the short isoform of myosin light chain kinase (MLCK1) catalyzed this reaction
Externí odkaz:
https://doaj.org/article/cfd5b73566534942a20862c48cbd93d9
Autor:
Xu Zhang, Yeye Guo, Ta Xiao, Jie Li, Aiyuan Guo, Li Lei, Chong Jin, Qi Long, Juan Su, Mingzhu Yin, Hong Liu, Chao Chen, Zhe Zhou, Susi Zhu, Juan Tao, Shuo Hu, Xiang Chen, Cong Peng
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-21 (2022)
Abstract Background Malignant transformation of the epidermis is an essential process in the pathogenesis of cutaneous squamous-cell carcinoma (cSCC). Although evidence has demonstrated that CD147 plays key roles in various tumors, the role of CD147
Externí odkaz:
https://doaj.org/article/ca3fd9603af646d3bebfee2b46fd40dc
Akademický článek
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Autor:
Jianan Li, Jianxiang Lin, Shisheng Huang, Min Li, Wenxia Yu, Yuting Zhao, Junfan Guo, Pumin Zhang, Xingxu Huang, Yunbo Qiao
Publikováno v:
Advanced Science, Vol 9, Iss 30, Pp n/a-n/a (2022)
Abstract Selective inhibition of targeted protein kinases is an effective therapeutic approach for treatment of human malignancies, which interferes phosphorylation of cellular substrates. However, a drug‐imposed selection creates pressures for tum
Externí odkaz:
https://doaj.org/article/3138ac8b45f34d1c87bd25c3ed52f91a
Autor:
Hai-Zhou Wu, Lan-Ya Li, Shi-Long Jiang, Yi-Zhi Li, Xiao-Mei Shi, Xin-Yuan Sun, Zhuo Li, Yan Cheng
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
BRAF inhibitors are commonly used in targeted therapies for melanoma patients harboring BRAFV600E mutant. Despite the benefit of vemurafenib therapy, acquired resistance during or after treatment remains a major obstacle in BRAFV600E mutant melanoma.
Externí odkaz:
https://doaj.org/article/32a637fa82144f2787d5d06f4ef4eb7b
Therapeutic Effect of Idebenone on Rats with Vascular Dementia via the MicroRNA-216a/RSK2/NF-κB Axis
Publikováno v:
Neuropsychiatric Disease and Treatment, Vol Volume 17, Pp 533-543 (2021)
Xudong Qian,1 Qianqian Xu,1 Guoyun Li,2 Yi Bu,1 Fan Sun,1 Jian Zhang1 1Department of Neurology, Affiliated Hospital of Chengde Medical University, Chengde, 067000, Hebei, People’s Republic of China; 2Department of Respiratory, Affiliated Hospital o
Externí odkaz:
https://doaj.org/article/5d828a956e4145549bd139a19d9dda29
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1798-1809 (2021)
Identifying isoform-specific inhibitors for closely related kinase family members remains a substantial challenge. The necessity for achieving this specificity is exemplified by the RSK family, downstream effectors of ERK1/2, which have divergent phy
Externí odkaz:
https://doaj.org/article/24e72094666b4d03bb12ea13e0ecdbd6
Autor:
Yayoi Matsumura‐Kimoto, Taku Tsukamoto, Yuji Shimura, Yoshiaki Chinen, Kazuna Tanba, Saeko Kuwahara‐Ota, Yuto Fujibayashi, Daichi Nishiyama, Reiko Isa, Junko Yamaguchi, Yuka Kawaji‐Kanayama, Tsutomu Kobayashi, Shigeo Horiike, Masafumi Taniwaki, Junya Kuroda
Publikováno v:
Cancer Medicine, Vol 9, Iss 14, Pp 5185-5199 (2020)
Abstract RSK2 is a serine/threonine kinase downstream signaling mediator in the RAS/ERK signaling pathway and may be a therapeutic target in mantle cell lymphoma (MCL), an almost incurable disease subtype of non‐Hodgkin lymphoma. In this study, ser
Externí odkaz:
https://doaj.org/article/9e1e7146637b4917811ff4b9c406b974