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pro vyhledávání: '"Rps6, ribosomal protein S6"'
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Autor:
Bernard L. Flynn, Ruth R Magaye, Xin Xiong, Peter J Meikle, Danny Liew, Feby Savira, Kevin Huynh, David M. Kaye, Bing Hui Wang, Christopher M. Reid
Publikováno v:
International Journal of Cardiology. Heart & Vasculature
International Journal of Cardiology: Heart & Vasculature, Vol 35, Iss, Pp 100837-(2021)
International Journal of Cardiology: Heart & Vasculature, Vol 35, Iss, Pp 100837-(2021)
Graphical abstract
Highlights • Increasing sphingolipid metabolism in cardiac fibroblasts inhibited TGFβ mediated collagen synthesis. • Dihydrosphingosine inhibits collagen synthesis in cardiac fibroblasts through substrate-enzyme-receptor
Highlights • Increasing sphingolipid metabolism in cardiac fibroblasts inhibited TGFβ mediated collagen synthesis. • Dihydrosphingosine inhibits collagen synthesis in cardiac fibroblasts through substrate-enzyme-receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7107d8c58bf953de354bb354b3a6ef20
https://pubmed.ncbi.nlm.nih.gov/34277924
https://pubmed.ncbi.nlm.nih.gov/34277924
Autor:
Ruixia Dong, Pingping Chen, Chung S. Yang, Xiaoxiao Wang, Ke Zhang, Jinsong Zhang, Dongxu Wang
Publikováno v:
Redox Biology, Vol 10, Iss C, Pp 221-232 (2016)
Redox Biology
Redox Biology
Selenium participates in the antioxidant defense mainly through a class of selenoproteins, including thioredoxin reductase. Epigallocatechin-3-gallate (EGCG) is the most abundant and biologically active catechin in green tea. Depending upon the dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7266d574e203ea4c2eff947b654886
http://www.sciencedirect.com/science/article/pii/S2213231716302129
http://www.sciencedirect.com/science/article/pii/S2213231716302129
Publikováno v:
EBioMedicine
Background Skin atrophy is a major adverse effect of topical glucocorticoids. We recently reported that REDD1 (regulated in development and DNA damage 1) and FKBP51 (FK506 binding protein 5), negative regulators of mTOR/Akt signaling, are induced by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff10e7b1dfa397ceac3419b5e6b841c
https://pubmed.ncbi.nlm.nih.gov/30737086
https://pubmed.ncbi.nlm.nih.gov/30737086
Autor:
Xiu-Fen Ming, Gautham Yepuri, Michael Forbiteh, Zhihong Yang, Jean-Pierre Montani, Yuyan Xiong, Yi Yu
Publikováno v:
Autophagy
Impaired autophagy function and enhanced ARG2 (arginase 2)-MTOR (mechanistic target of rapamycin) crosstalk are implicated in vascular aging and atherosclerosis. We are interested in the role of ARG2 and the potential underlying mechanism(s) in modul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5108959ca172d61ef5a4bdfe8419c9b
https://doi.org/10.4161/15548627.2014.981789
https://doi.org/10.4161/15548627.2014.981789
Autor:
Brian K. Law, Jae-Sung Kim, Pouran Habibzadegah-Tari, Xiao Ming Yin, Min Li, S. Keisin Wang, Nicole A. Horenstein, David A. Ostrov, William A. Dunn, Debra Akin
Publikováno v:
Autophagy
Autophagy has been implicated in the progression and chemoresistance of various cancers. In this study, we have shown that osteosarcoma Saos-2 cells lacking ATG4B, a cysteine proteinase that activates LC3B, are defective in autophagy and fail to form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb8cbf8795014b07d7b6ab3f1710117
https://doi.org/10.4161/auto.32229
https://doi.org/10.4161/auto.32229
Autor:
Grasso, Silvina, Tristante, Elena, Saceda, Miguel, Carbonell, Pablo, Mayor-López, Leticia, Carballo-Santana, Mar, Carrasco-García, Estefanía, Rocamora-Reverte, Lourdes, García-Morales, Pilar, Carballo, Fernando, Ferragut, José A., Martínez-Lacaci, Isabel
Publikováno v:
Neoplasia (New York, N.Y.)
Selumetinib (AZD6244, ARRY-142886) is a MEK1/2 inhibitor that has gained interest as an anti-tumour agent. We have determined the degree of sensitivity/resistance to Selumetinib in a panel of colorectal cancer cell lines using cell proliferation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b7b38e2a48ee06150c6d97f0d3a36df4
http://europepmc.org/articles/PMC4212257
http://europepmc.org/articles/PMC4212257
Autor:
Calum C. Bain, Foo Y. Liew, Ananda S. Mirchandani, Anne-Gaelle Besnard, Neil C. Thomson, Robert J. Salmond
Publikováno v:
The Journal of Allergy and Clinical Immunology
Background: The IL-1 family cytokine IL-33 is involved in the induction of airway inflammation in allergic patients and after viral infection. Several cell types, including CD4 1 TH2 cells and the recently described type 2 innate lymphoid cells (ILCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5cfddcfe91f7be30f8547bc2fc489c3
http://europepmc.org/articles/PMC3664950
http://europepmc.org/articles/PMC3664950
Autor:
Zakaria, Albatoul, Berthault, Claire, Cosson, Bertrand, Jung, Vincent, Guerrera, Ida Chiara, Rachdi, Latif, Scharfmann, Raphael
Publikováno v:
The Journal of Biological Chemistry
Glucose-mediated signaling regulates the expression of a limited number of genes in human pancreatic β-cells at the transcriptional level. However, it is unclear whether glucose plays a role in posttranscriptional RNA processing or translational con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::086e8c31a0aa12b12b5069857d6dcb91
Autor:
Bardeck N; Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine University Hospital, Düsseldorf, Germany., Paluschinski M; Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine University Hospital, Düsseldorf, Germany., Castoldi M; Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine University Hospital, Düsseldorf, Germany., Kordes C; Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine University Hospital, Düsseldorf, Germany., Görg B; Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine University Hospital, Düsseldorf, Germany., Stindt J; Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine University Hospital, Düsseldorf, Germany., Luedde T; Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine University Hospital, Düsseldorf, Germany., Dahl SV; Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine University Hospital, Düsseldorf, Germany., Häussinger D; Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine University Hospital, Düsseldorf, Germany., Schöler D; Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine University Hospital, Düsseldorf, Germany.
Publikováno v:
JHEP reports : innovation in hepatology [JHEP Rep] 2022 Jan 22; Vol. 4 (4), pp. 100440. Date of Electronic Publication: 2022 Jan 22 (Print Publication: 2022).