18Fluorodeoxyglucose Accumulation in Arterial Tissues Determined by PET Signal Analysis

Autor: Michael Winterdahl, Zahra P. Nasr, Zheer Al-Mashhadi, Martin M. Bjørklund, Jacob F. Bentzon, Lars Poulsen Tolbod, Jørgen Frøkiær, Rozh H Al-Mashhadi, Erling Falk, Lars Ø Bloch

Publikováno v: Al-Mashhadi, R H, Tolbod, L P, Bloch, L, Bjørklund, M M, Nasr, Z P, Al-Mashhadi, Z, Winterdahl, M, Frøkiær, J, Falk, E & Bentzon, J F 2019, ' 18 Fluorodeoxyglucose Accumulation in Arterial Tissues Determined by PET Signal Analysis ', Journal of the American College of Cardiology, vol. 74, no. 9, pp. 1220-1232 . https://doi.org/10.1016/j.jacc.2019.06.057
Repisalud
Instituto de Salud Carlos III (ISCIII)

BACKGROUND: Arterial 18fluorodeoxyglucose (FDG) positron emission tomography (PET) is considered a measure of atherosclerotic plaque macrophages and is used for quantification of disease activity in clinical trials, but the distribution profile of FD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc99682fa67670b39ac4a69061f98bff
https://doi.org/10.1016/j.jacc.2019.06.057

Local Pressure Drives Low-Density Lipoprotein Accumulation and Coronary Atherosclerosis in Hypertensive Minipigs

Autor: Jesús Vázquez, Jesper M. Jensen, Erling Falk, K. Ravlo, Peter Bie, Martin Bødtker Mortensen, Zahra P. Nasr, Rozh H Al-Mashhadi, Ahmed Ludvigsen Al-Mashhadi, Johan Palmfeldt, Esmeralda A. Lewis, Daniel Kjær, Emilio Camafeita, Jacob F. Bentzon, Zheer Al-Mashhadi, Bjarne L. Nørgaard

Publikováno v: Al-Mashhadi, R H, Al-Mashhadi, A L, Nasr, Z P, Mortensen, M B, Lewis, E A, Camafeita, E, Ravlo, K, Al-Mashhadi, Z, Kjær, D W, Palmfeldt, J, Bie, P, Jensen, J M, Nørgaard, B L, Falk, E, Vázquez, J & Bentzon, J F 2021, ' Local Pressure Drives Low-Density Lipoprotein Accumulation and Coronary Atherosclerosis in Hypertensive Minipigs ', Journal of the American College of Cardiology, vol. 77, no. 5, pp. 575-589 . https://doi.org/10.1016/j.jacc.2020.11.059

Background The mechanisms by which hypertension accelerates coronary artery disease are poorly understood. Patients with hypertension often have confounding humoral changes, and to date, no experimental models have allowed analysis of the isolated ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c0e5d020292c6b800a1e24555171c4
https://pure.au.dk/portal/da/publications/local-pressure-drives-lowdensity-lipoprotein-accumulation-and-coronary-atherosclerosis-in-hypertensive-minipigs(a0ede8d9-e0d7-488f-ab95-998d83afd28e).html

Treatment with a human recombinant monoclonal IgG antibody against oxidized LDL in atherosclerosis-prone pigs reduces cathepsin S in coronary lesions

Autor: Ludovic Drouet, Ahmed Tawakol, Esad Vucic, Jill Fredrickson, Rozh H Al-Mashhadi, Christian Bo Poulsen, Anna-Karin L. Robertson, Søren K. Moestrup, Jesper Thygesen, Jacob F. Bentzon, Ahmed Ludvigsen Al-Mashhadi, Erling Falk, Jens Rolighed Larsen, Lars Bo Nielsen, Lars Poulsen Tolbod, Karin von Wachenfeldt, Amos Baruch, Björn Frendéus, Jørgen Frøkiær

Publikováno v: Poulsen, C B, Al-Mashhadi, A L, von Wachenfeldt, K, Bentzon, J F, Nielsen, L B, Al-Mashhadi, R H, Thygesen, J, Tolbod, L, Larsen, J R, Frøkiær, J, Tawakol, A, Vucic, E, Fredrickson, J, Baruch, A, Frendéus, B, Robertson, A-K L, Moestrup, S K, Drouet, L & Falk, E 2016, ' Treatment with a human recombinant monoclonal IgG antibody against oxidized LDL in atherosclerosis-prone pigs reduces cathepsin S in coronary lesions ', International Journal of Cardiology, vol. 215, pp. 506-515 . https://doi.org/10.1016/j.ijcard.2016.03.222

BACKGROUND: Immunization with oxidized LDL (oxLDL) reduces atherosclerosis in rodents. We tested the hypothesis that treatment with a human recombinant monoclonal antibody against oxLDL will reduce the burden or composition of atherosclerotic lesions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01eb048def768283c24deb9d95bf08f8
https://doi.org/10.1016/j.ijcard.2016.03.222

Diet-Induced Abdominal Obesity, Metabolic Changes, and Atherosclerosis in Hypercholesterolemic Minipigs

Autor: Erling Falk, Christian Bo Poulsen, Søren K. Moestrup, Brynjulf Mortensen, Ludovic Drouet, Rozh H Al-Mashhadi, Jacob F. Bentzon, Anna-Karin L. Robertson, Lars Poulsen Tolbod, Karin von Wachenfeldt, Jens Rolighed Larsen, Lars Bo Nielsen, Jesper Thygesen, Ahmed Ludvigsen Al-Mashhadi, Björn Frendéus

Publikováno v: Journal of Diabetes Research, Vol 2018 (2018)
Journal of Diabetes Research
Al-Mashhadi, A L, Poulsen, C B, von Wachenfeldt, K, Robertson, A-K, Bentzon, J F, Nielsen, L B, Thygesen, J, Tolbod, L P, Larsen, J R, Moestrup, S K, Frendéus, B, Mortensen, B, Drouet, L, Al-Mashhadi, R H & Falk, E 2018, ' Diet-Induced Abdominal Obesity, Metabolic Changes, and Atherosclerosis in Hypercholesterolemic Minipigs ', Journal of Diabetes Research, vol. 2018, 6823193 . https://doi.org/10.1155/2018/6823193
Al-Mashhadi, A L, Poulsen, C B, von Wachenfeldt, K, Robertson, A-K L, Bentzon, J F, Nielsen, L B, Thygesen, J, Tolbod, L P, Larsen, J R, Moestrup, S K, Frendéus, B, Mortensen, B, Drouet, J-L, Al-Mashhadi, R & Falk, E 2018, ' Diet-Induced Abdominal Obesity, Metabolic Changes, and Atherosclerosis in Hypercholesterolemic Minipigs ', Journal of Diabetes Research, vol. 2018, 6823193 . https://doi.org/10.1155/2018/6823193
BASE-Bielefeld Academic Search Engine

Background. Obesity and metabolic syndrome (MetS) are major risk factors for atherosclerotic diseases; however, a causal link remains elusive. Animal models resembling human MetS and its complications, while important, are scarce. We aimed at develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ccc3f3ac07ce6115acc097691801966
https://doaj.org/article/2c21b3e715324ff9bbb4daf88ef55399

Diabetes with poor glycaemic control does not promote atherosclerosis in genetically modified hypercholesterolaemic minipigs

Autor: Erling Falk, Jacob F. Bentzon, Martin Bødtker Mortensen, Rozh H Al-Mashhadi, Christina Christoffersen, Martin M. Bjørklund, Torben Larsen

Publikováno v: Al-Mashhadi, R H, Bjørklund, M M, Mortensen, M B, Christoffersen, C, Larsen, T, Falk, E & Bentzon, J F 2015, ' Diabetes with poor glycaemic control does not promote atherosclerosis in genetically modified hypercholesterolaemic minipigs ', Diabetologia . https://doi.org/10.1007/s00125-015-3637-1

AIMS/HYPOTHESIS: Diabetes is associated with an increased risk of atherosclerotic cardiovascular disease, but whether there is a direct and independent role for impaired glucose control in atherogenesis remains uncertain. We investigated whether diab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60fe3247c73227b4cc0a031f3d3c8ce8
https://doi.org/10.1007/s00125-015-3637-1