Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Roza Selimyan"'
Autor:
Roza Selimyan, Rachel M Gerstein, Irina Ivanova, Patricia Precht, Ramesh Subrahmanyam, Thomas Perlot, Frederick W Alt, Ranjan Sen
Publikováno v:
PLoS Biology, Vol 11, Iss 1, p e1001475 (2013)
Multiple epigenetic marks have been proposed to contribute to the regulation of antigen receptor gene assembly via V(D)J recombination. Here we provide a comprehensive view of DNA methylation at the immunoglobulin heavy chain (IgH) gene locus prior t
Externí odkaz:
https://doaj.org/article/da7279c959ba4adf98b054966dd8c55f
Autor:
Karen S Hathcock, Lila Farrington, Irina Ivanova, Ferenc Livak, Roza Selimyan, Ranjan Sen, Joy Williams, Xuguang Tai, Richard J Hodes
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20639 (2011)
T cell development occurs in the thymus and is critically dependent on productive TCRβ rearrangement and pre-TCR expression in DN3 cells. The requirement for pre-TCR expression results in the arrest of thymocytes at the DN3 stage (β checkpoint), wh
Externí odkaz:
https://doaj.org/article/249b9fedd00d485e85240b65e0a4f66b
Autor:
Je-Hyun Yoon, Roza Selimyan, Amaresh C. Panda, Supriyo De, Kevin G. Becker, William H. Wood rd, Kotb Abdelmohsen, Jennifer L. Martindale, Jason Xu, Myriam Gorospe, Min Ju Kang
Publikováno v:
Aging Cell. 12:890-900
Noncoding RNAs include small transcripts, such as microRNAs and piwi-interacting RNAs, and a wide range of long noncoding RNAs (lncRNAs). Although many lncRNAs have been identified, only a small number of lncRNAs have been characterized functionally.
Autor:
Irina Ivanova, Eugene M. Oltz, Ranjan Sen, Tirtha Chakraborty, Changying Guo, Roza Selimyan, Tatiana I. Gerasimova, Haiping Hao
Publikováno v:
Cell. 147(2):332-343
SummaryThe immunoglobulin heavy-chain (IgH) gene locus undergoes radial repositioning within the nucleus and locus contraction in preparation for gene recombination. We demonstrate that IgH locus conformation involves two levels of chromosomal compac
Autor:
Kotb Abdelmohsen, Kumiko Tominaga, Eun Kyung Lee, Subramanya Srikantan, Min-Ju Kang, Mihee M. Kim, Roza Selimyan, Jennifer L. Martindale, Xiaoling Yang, France Carrier, Ming Zhan, Kevin G. Becker, Myriam Gorospe
Publikováno v:
Nucleic Acids Research
RNA-binding proteins (RBPs) regulate gene expression at many post-transcriptional levels, including mRNA stability and translation. The RBP nucleolin, with four RNA-recognition motifs, has been implicated in cell proliferation, carcinogenesis and vir
Autor:
Elin Lehrmann, Eun Kyung Lee, Jennifer L. Martindale, Myriam Gorospe, Mihee M. Kim, Kotb Abdelmohsen, Kevin G. Becker, Xiaoling Yang, Hyeon Ho Kim, Yongqing Zhang, Subramanya Srikantan, Roza Selimyan, Jian-Ying Wang, Kiyoshi Masuda, Kumiko Tominaga
Publikováno v:
The EMBO Journal. 30:1040-1053
Ionizing radiation (IR) triggers adaptive changes in gene expression. Here, we show that survival after IR strongly depends on the checkpoint kinase Chk2 acting upon its substrate HuR, an RNA-binding protein that stabilizes and/or modulates the trans
Publikováno v:
Experimental and Clinical Endocrinology & Diabetes. 116:437-442
Locally produced estrogens are important paracrine regulators of placental growth and differentiation in cattle and sheep. The key enzyme of estrogen biosynthesis, aromatase cytochrome P450, is encoded by CYP19. Transcription of this gene in fetal co
Autor:
Lila Farrington, Roza Selimyan, Joy A. Williams, Richard J. Hodes, Karen S. Hathcock, Irina Ivanova, Xuguang Tai, Ranjan Sen, Ferenc Livak
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 6, p e20639 (2011)
PLoS ONE, Vol 6, Iss 6, p e20639 (2011)
T cell development occurs in the thymus and is critically dependent on productive TCRβ rearrangement and pre-TCR expression in DN3 cells. The requirement for pre-TCR expression results in the arrest of thymocytes at the DN3 stage (β checkpoint), wh
Autor:
Kiyoshi, Masuda, Kotb, Abdelmohsen, Mihee M, Kim, Subramanya, Srikantan, Eun Kyung, Lee, Kumiko, Tominaga, Roza, Selimyan, Jennifer L, Martindale, Xiaoling, Yang, Elin, Lehrmann, Yongqing, Zhang, Kevin G, Becker, Jian-Ying, Wang, Hyeon Ho, Kim, Myriam, Gorospe
Publikováno v:
The EMBO journal. 30(6)
Ionizing radiation (IR) triggers adaptive changes in gene expression. Here, we show that survival after IR strongly depends on the checkpoint kinase Chk2 acting upon its substrate HuR, an RNA-binding protein that stabilizes and/or modulates the trans
Publikováno v:
Molecular reproduction and development. 75(1)
Placental oestrogens play an important role as local regulators of placental growth and differentiation during gestation, and toward term they are also involved in the preparation of parturition. They are synthesized within the fetal cotyledons of pl