Výsledky vyhledávání - "Roza Ishihara"

ANTIGENICITY STUDY OF TRANDOLAPRIL (RU44570)

Autor: Hiroshi Wada, Masami Kato, Fumihiko Aruga, Yoshiaki Hongo, Roza Ishihara, Sakae Iwasaki, Yasushi Yamada

Publikováno v: The Journal of Toxicological Sciences. 18:161-175

Antigenicity of trandolapril (RU44570) was evaluated using the following six standpoints: 1. active systemic anaphylaxis (ASA) in guinea pigs; 2. passive cutaneous anaphylaxis (PCA) in guinea pigs with serum of sensitized guinea pigs; 3. histamine re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146404f27c088a281ee9f54c3a90d250
https://doi.org/10.2131/jts.18.supplementi_161

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Intrapulmonary Pharmacokinetics of Telithromycin, a New Ketolide, in Healthy Japanese Volunteers

Autor: Kazunori Tomono, Iwashita T, Claudette Muller-Serieys, Yuji Ishimatsu, Shigeru Kohno, Roza Ishihara, Y. Matsubara, Jun-ichi Kadota, Masao Tateno

The concentrations of telithromycin, a new ketolide antimicrobial agent, in alveolar macrophages (AMs) and bronchoalveolar epithelial lining fluid (ELF) were determined in order to investigate the transfer of the drug into target tissue, relative to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ae7834d45eea34982564a321601326
https://europepmc.org/articles/PMC127464/

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[Reverse mutation test of trandolapril (RU44570) with bacteria]

Autor: Roza Ishihara, Rika Tanaka, Yoshiko Nagasawa, Fumihiko Aruga

Publikováno v: The Journal of toxicological sciences. 18

Mutagenicity of trandolapril (RU44570) was evaluated by the reverse mutation test with bacteria (test strains used: Salmonella typhimurium TA100, TA98, TA1535, TA1537 and Escherichia coli WP2uvrA). The test was conducted by the preincubation method w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f468098790ccdb9775501cd600a53246
https://pubmed.ncbi.nlm.nih.gov/8515502

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[Thirteen-week repeated dose toxicity by oral administration of trandolapril (RU44570) with 4-week recovery test in beagles]

Autor: Roza Ishihara, Hajime Obi, Yasuki Akie, Atsuko Ichikawa, Michio Inage, Masao Nakazawa, Noritsugu Shimizu, Masanori Sakaguchi, Fumio Masaki

Publikováno v: The Journal of toxicological sciences. 18

Trandolapril (RU44570) was orally administered to dogs at a daily dose of 2.5, 25 or 250 mg/kg for 13 weeks. After the administration period, 25 and 250 mg/kg groups were observed for recovery for 4 weeks. The results obtained are as follows: 1. One

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88a3cf9baff5ef48dc86c432c61f077
https://pubmed.ncbi.nlm.nih.gov/8515498

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