Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Roya, Zoraghi"'
Autor:
Roya Zoraghi, Neil E. Reiner, James P. Morrison, Clinton G. L. Veale, Kevin A. Lobb, Raymond J. Andersen, Michael T. Davies-Coleman
Publikováno v:
Tetrahedron. 70:7845-7853
The public health care crisis caused by the emergence of drug resistant bacterial strains, e.g., methicillin resistant Staphylococcus aureus (MRSA) has underlined the urgent need to accelerate the discovery of new chemical entities active against ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04598f886a54e9b0ea1e2813c188780c
https://doi.org/10.1016/j.tet.2014.09.007
https://doi.org/10.1016/j.tet.2014.09.007
Autor:
Robert N. Young, B. Brett Finlay, Neil E. Reiner, Anthony R. Richardson, J. Jon Paul Selvam, Roya Zoraghi, Sara Campbell, Lisa Thorson, Nag S. Kumar, Nicholas P. Vitko, Huansheng Gong, Edie Dullaghan
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:1708-1725
A novel series of bis-indoles derived from naturally occurring marine alkaloid 4 were synthesized and evaluated as inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase (PK). PK is not only critical for bacterial survival w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::535c9726aef83f1a822f866924e24d63
https://doi.org/10.1016/j.bmc.2014.01.020
https://doi.org/10.1016/j.bmc.2014.01.020
Autor:
Roya Zoraghi, Neil E. Reiner
Publikováno v:
Current Opinion in Microbiology. 16:566-572
Novel classes of antimicrobials are needed to address the challenge of multidrug-resistant bacteria. Current bacterial drug targets mainly consist of specific proteins or subsets of proteins without regard for either how these targets are integrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313771168ecafd3ce925e4d4f5deb541
https://doi.org/10.1016/j.mib.2013.07.010
https://doi.org/10.1016/j.mib.2013.07.010
Autor:
Emily Amandoron, B. Brett Finlay, Liam J. Worrall, Nag S. Kumar, Sukhbir Kaur, Lisa Thorson, Huansheng Gong, Roya Zoraghi, Neil E. Reiner, Edwin W. Y. Wong, Raymond H. See, Christophe Labriere, Artem Cherkasov, Anne Moreau, Natalie C. J. Strynadka, Robert N. Young, Linda A. Jackson, Tian Lian
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:7069-7082
A novel series of hydrazones were synthesized and evaluated as inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase (PK). PK has been identified as one of the most highly connected 'hub proteins' in MRSA. PK has been shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a096570047bdf0abf938f31f150568c7
https://doi.org/10.1016/j.bmc.2012.10.002
https://doi.org/10.1016/j.bmc.2012.10.002
Autor:
Nikolay Stoynov, Artem Cherkasov, Natalie C. J. Strynadka, Sukhbir Kaur, Michael Hsing, Robert N. Young, Jihong Jiang, Emily Amandoron, Leonard J. Foster, Nag S. Kumar, Anne Moreau, Linda A. Jackson, B. Brett Finlay, Liam Worral, Huansheng Gong, Rick Swayze, William R. McMaster, Peter Axerio-Cilies, Roya Zoraghi, Raymond H. See, Tian Lian, Neil E. Reiner
Publikováno v:
ACS Chemical Biology. 7:350-359
We have recently mapped the protein interaction network of methicillin-resistant Staphylococcus aureus (MRSA), which revealed its scale-free organization with characteristic presence of highly connected hub proteins that are critical for bacterial su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c612ae77a74aa36df0d08ee0ce89ee3
https://doi.org/10.1021/cb2003576
https://doi.org/10.1021/cb2003576
Autor:
Sukhbir Kaur, B. Brett Finlay, Phuong Dao, Cenk Sahinalp, William R. McMaster, Emily Amandoron, Rick Swayze, Leonard J. Foster, Raymond H. See, Robert C. Brunham, Peter Axerio-Cilies, Neil E. Reiner, Farhad Hormozdiari, Nikolay Stoynov, Artem Cherkasov, Huansheng Gong, Tian Lian, Linda A. Jackson, Osvaldo A. Santos-Filho, Michael Hsing, Roya Zoraghi, Kendall G. Byler, Jihong Jiang
Publikováno v:
Journal of Proteome Research. 10:1139-1150
Mortality attributable to infection with methicillin-resistant Staphylococcus aureus (MRSA) has now overtaken the death rate for AIDS in the United States, and advances in research are urgently needed to address this challenge. We report the results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2214ff6fcc74f5b394ac20256f18a5fa
https://doi.org/10.1021/pr100918u
https://doi.org/10.1021/pr100918u
Publikováno v:
Biochemistry. 46:10353-10364
The phosphodiesterase-11A (PDE11) family consists of four splice variants (PDE11A1-PDE11A4) that contain a conserved carboxyl-terminal (C-terminal) catalytic domain that hydrolyzes cAMP and cGMP; the amino-termini (N-termini) vary in length and amino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307d751932f441f97039e4d701e6fd33
https://doi.org/10.1021/bi7009629
https://doi.org/10.1021/bi7009629
Autor:
Knut Ohlsen, Mardia Telep El-Sayed, Michael Lalk, Sibel Suzen, Roya Zoraghi, Nurten Altanlar, Neil E. Reiner, Andreas Hilgeroth
Novel bisindolyl-cycloalkane indoles resulted from the reaction of aliphatic dialdehydes and indole. As bisindolyl-natural alkaloid compounds have recently been reported as inhibitors of the methicillin-resistant Staphylococcus aureus (MRSA)-pyruvate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67fee4cc61be459b348f72dd1b0f6098
Autor:
Jiwen Cai, Roya Zoraghi, Howard Robinson, Yudong Liu, Qing Huai, Huanchen Wang, Jackie D. Corbin, Guiting Lin, Sharron H. Francis, Zhongcheng Xin, Hengming Ke
Publikováno v:
Journal of Biological Chemistry. 281:21469-21479
Phosphodiesterase-5 (PDE5) is the target for sildenafil, vardenafil, and tadalafil, which are drugs for treatment of erectile dysfunction and pulmonary hypertension. We report here the crystal structures of a fully active catalytic domain of unligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::921c223e8b83518c563c151fd434e586
https://doi.org/10.1074/jbc.m512527200
https://doi.org/10.1074/jbc.m512527200
Publikováno v:
Journal of Biological Chemistry. 281:5553-5558
The side group of an invariant Gln in cGMP- and cAMP-specific phosphodiesterases (PDE) is held in different orientations by bonds with other amino acids and purportedly discriminates between guanine and adenine in cGMP and cAMP. In cGMP-specific PDE5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0801b9045b5a6200af9fa80afa7da467
https://doi.org/10.1074/jbc.m510372200
https://doi.org/10.1074/jbc.m510372200