Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Roy Ummels"'
Autor:
Meng Zhang, Sabir Adroub, Roy Ummels, Mohammed Asaad, Lei Song, Arnab Pain, Wilbert Bitter, Qingtian Guan, Abdallah M. Abdallah
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Mycobacteria is a diverse genus that includes both innocuous environmental species and serious pathogens like Mycobacterium tuberculosis, Mycobacterium leprae, and Mycobacterium ulcerans, the causative agents of tuberculosis, leprosy, and Bu
Externí odkaz:
https://doaj.org/article/d6945d1d86bb48d68b1bbac72356690a
Autor:
Beatriz Izquierdo Lafuente, Theo Verboom, Sita Coenraads, Roy Ummels, Wilbert Bitter, Alexander Speer
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 6 (2024)
ABSTRACT Vitamin B12 (B12) serves as a critical cofactor within mycobacterial metabolism. While some pathogenic strains can synthesize B12 de novo, others rely on host-acquired B12. In this investigation, we studied the transport of vitamin B12 in My
Externí odkaz:
https://doaj.org/article/81c6e0debf22470181d72ec94c5a4631
Autor:
Qingtian Guan, Roy Ummels, Fathia Ben-Rached, Yara Alzahid, Mohammad S. Amini, Sabir A. Adroub, Jakko van Ingen, Wilbert Bitter, Abdallah M. Abdallah, Arnab Pain
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Mycobacterium kansasii is an important opportunistic pathogen of humans and has a close phylogenetic relationship with Mycobacterium tuberculosis. Seven subtypes (I–VII) have been identified using molecular biology approaches, of which subtype I is
Externí odkaz:
https://doaj.org/article/4f4e5c3d72774c9b921df1666201ab4d
Autor:
Ping Lu, Amer H. Asseri, Martijn Kremer, Janneke Maaskant, Roy Ummels, Holger Lill, Dirk Bald
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
Abstract Mycobacterial energy metabolism currently attracts strong attention as new target space for development of anti-tuberculosis drugs. The imidazopyridine Q203 targets the cytochrome bcc complex of the respiratory chain, a key component in ener
Externí odkaz:
https://doaj.org/article/f3ff05a4c9b840efb2333c8bfd9914f6
Autor:
Maroeska J. Burggraaf, Alexander Speer, Aniek S. Meijers, Roy Ummels, Astrid M. van der Sar, Konstantin V. Korotkov, Wilbert Bitter, Coenraad Kuijl
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT Tuberculosis, one of the world’s most severe infectious diseases, is caused by Mycobacterium tuberculosis. A major weapon of this pathogen is a unique cell wall that protects the pathogen from eradication by the immune system. Mycobacteria
Externí odkaz:
https://doaj.org/article/471da19eeb16404ebd6a78080b66c8b0
Autor:
Abdallah M Abdallah, Eveline M Weerdenburg, Qingtian Guan, Roy Ummels, Stephanie Borggreve, Sabir A Adroub, Tareq B Malas, Raeece Naeem, Huoming Zhang, Thomas D Otto, Wilbert Bitter, Arnab Pain
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0211003 (2019)
The mycobacterial type VII secretion system ESX-1 is responsible for the secretion of a number of proteins that play important roles during host infection. The regulation of the expression of secreted proteins is often essential to establish successf
Externí odkaz:
https://doaj.org/article/f34212ee8a7f4fe08eb2f2189dbf0663
Autor:
Trang H Phan, Lisanne M van Leeuwen, Coen Kuijl, Roy Ummels, Gunny van Stempvoort, Alba Rubio-Canalejas, Sander R Piersma, Connie R Jiménez, Astrid M van der Sar, Edith N G Houben, Wilbert Bitter
Publikováno v:
PLoS Pathogens, Vol 14, Iss 8, p e1007247 (2018)
The pathogen Mycobacterium tuberculosis employs a range of ESX-1 substrates to manipulate the host and build a successful infection. Although the importance of ESX-1 secretion in virulence is well established, the characterization of its individual c
Externí odkaz:
https://doaj.org/article/168aa6b95d0e4e7c9b73b8e47bd923a8
Autor:
Louis S Ates, Fadel Sayes, Wafa Frigui, Roy Ummels, Merel P M Damen, Daria Bottai, Marcel A Behr, Jeroen W J van Heijst, Wilbert Bitter, Laleh Majlessi, Roland Brosch
Publikováno v:
PLoS Pathogens, Vol 14, Iss 6, p e1007139 (2018)
Tuberculosis is the deadliest infectious disease worldwide. Although the BCG vaccine is widely used, it does not efficiently protect against pulmonary tuberculosis and an improved tuberculosis vaccine is therefore urgently needed. Mycobacterium tuber
Externí odkaz:
https://doaj.org/article/59cdf3a2345a4a53948f740e2258720b
Autor:
Maikel Boot, Vincent J C van Winden, Marion Sparrius, Robert van de Weerd, Alexander Speer, Roy Ummels, Tige Rustad, David R Sherman, Wilbert Bitter
Publikováno v:
PLoS Genetics, Vol 13, Iss 12, p e1007131 (2017)
The cell envelope of mycobacteria is a highly unique and complex structure that is functionally equivalent to that of Gram-negative bacteria to protect the bacterial cell. Defects in the integrity or assembly of this cell envelope must be sensed to a
Externí odkaz:
https://doaj.org/article/8868350f93d743d58cc283a2b3313435
Autor:
Vincent J. C. van Winden, Roy Ummels, Sander R. Piersma, Connie R. Jiménez, Konstantin V. Korotkov, Wilbert Bitter, Edith N. G. Houben
Publikováno v:
mBio, Vol 7, Iss 5 (2016)
ABSTRACT Pathogenic mycobacteria contain up to five type VII secretion (T7S) systems, ESX-1 to ESX-5. One of the conserved T7S components is the serine protease mycosin (MycP). Strikingly, whereas MycP is essential for secretion, the protease activit
Externí odkaz:
https://doaj.org/article/bf7cb1e658b14d3a818312f43e42cc8a