Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Roy Turton"'
Autor:
Geoffrey Martyn Williams, Felix Spindler, Daniel Black, Philippe Wong-Kai-In, P. John Murray, Martin James Procter, Rosemary Chatfield, Lisa Sarah Bertram, Andrew Cooke, Kosuke Yasuda, Roy Turton, Paul H. Briner, Frédéric Naud, Karen Lesley Schofield, Günaj Rakipovski, Amanda Taylor, Masao Nawano, Christine Reynet, Chrystelle Marie Rasamison, Matthew Colin Thor Fyfe, Vilas K. Shah
Publikováno v:
Journal of Medicinal Chemistry. 51:4340-4345
Allosteric activators of the glucose-sensing enzyme glucokinase (GK) are currently attracting much interest as potential antidiabetic therapies because they can achieve powerful blood glucose lowering through actions in multiple organs. Here, the opt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96638620f497a62ba910de15908f24ed
https://doi.org/10.1021/jm8003202
https://doi.org/10.1021/jm8003202
Autor:
Yue Peng, Hanqing Dong, Xin Chen, Arno G. Steinig, Darla Landfair, David Epstein, Ryan Schulz, Paula A. Tavares-Greco, Meizhong Jin, Andy Cooke, Jonathan A. Pachter, Jen Workman, Jennifer Kahler, Kathryn M. Stolz, Christine Mantis, Linda Crew, Ti Wang, Mark J. Mulvihill, Mridula Kadalbajoo, Jing Wang, Maryland Franklin, Caterina Ferraro, Robert A. Wild, Julie Kan, Prafulla C. Gokhale, Mark Albertella, Roy Turton, An-Hu Li, Mark Bittner, Andrew Kleinberg
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(15)
A series of novel 6-aminofuro[3,2-c]pyridines as kinase inhibitors is described, most notably, OSI-296 (6). We discuss our exploration of structure-activity relationships and optimization leading to OSI-296 and disclose its pharmacological activity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec66757e923fb29bc802fa5ffc251b43
https://pubmed.ncbi.nlm.nih.gov/23773865
https://pubmed.ncbi.nlm.nih.gov/23773865
Autor:
Prafulla C. Gokhale, Darla Landfair, Julie Kan, Jonathan A. Pachter, Andrew Kleinberg, Meizhong Jin, Ti Wang, Mark J. Mulvihill, Arno G. Steinig, Yue Peng, Roy Turton, An-Hu Li, Kathryn M. Stolz Gavagan, Siobhan McCormack, Hanqing Dong, Jing Wang, Maryland Franklin, Mark Bittner, Linda Castaldo, Jen Kahler, David Epstein, Paula A. Tavares-Greco, Andy Cooke, Robert A. Wild, Mark Albertella
Publikováno v:
Cancer Research. 72:2915-2915
cMET and RON are receptor tyrosine kinases of the MET proto-oncogene family that are activated by their respective ligands HGF and MSP. Signaling through the cMET/HGF system can be deregulated in cancer by HGF-dependent autocrine activation, gene amp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2664f7beea5f99d9c42a1bf921ffe4ab
https://doi.org/10.1158/1538-7445.am2012-2915
https://doi.org/10.1158/1538-7445.am2012-2915
Autor:
Lisa S. Bertram, Daniel Black, Paul H. Briner, Rosemary Chatfield, Andrew Cooke, P. John Murray, Frédéric Naud, Masao Nawano, Martin J. Procter, Günaj Rakipovski, Chrystelle M. Rasamison, Christine Reynet, Karen L. Schofield, Vilas K. Shah, Felix Spindler, Amanda Taylor, Roy Turton, Geoffrey M. Williams, Philippe Wong-Kai-In, Kosuke Yasuda
Publikováno v:
Journal of Medicinal Chemistry; Jun2008, Vol. 51 Issue 14, p4340-4345, 6p