Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Roy R. Woldhuis"'
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Akademický článek
Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?
Autor: Corry-Anke Brandsma, Maaike de Vries, Rita Costa, Roy R. Woldhuis, Melanie Königshoff, Wim Timens
Publikováno v: European Respiratory Review, Vol 26, Iss 146 (2017)
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide, with increasing prevalence, in particular in the elderly. COPD is characterised by abnormal tissue repair resulting in (small) airways disease and emphysema.
Externí odkaz: https://doaj.org/article/93f2a5a80d0f4aada3bc8154e1cba413
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2
A proteomics approach to identify COPD-related changes in lung fibroblasts
Autor: Nicolaas J. Bekker, Alienke van Pijkeren, Justina C. Wolters, Alejandro Sánchez Brotons, Victor Guryev, Roy R. Woldhuis, Rainer Bischoff, Wynand Alkema, Peter Horvatovich, Johannes L. L. van Nijnatten, Maarten van den Berge, Wim Timens, Corry-Anke Brandsma
Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology, 324(4), L521-L535. American Physiological Society
American Journal of Physiology-Lung Cellular and Molecular Physiology. AMER PHYSIOLOGICAL SOC
BACKGROUND: Lung fibroblasts are implicated in abnormal tissue repair in chronic obstructive pulmonary disease (COPD). The exact mechanisms are unknown and comprehensive analysis comparing COPD- and control fibroblasts is lacking.AIM: To gain insight
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad0ea9e828c0a1a9e58247d53e7e32b
https://research.hanze.nl/en/publications/f61fbd50-2a36-4acc-a316-509e8855250a
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3
BET proteins are associated with the induction of small airway fibrosis in COPD
Autor: Karosham D. Reddy, Sandra Rutting, Corry-Anke Brandsma, Dikaia Xenaki, Jack Bozier, Brian G. Oliver, Yik Lung Chan, Hui Chen, Razia Zakarya, Ian M. Adcock, Roy R Woldhuis, David Van Ly
Publikováno v: Thorax, 76(7), 647-655. BMJ PUBLISHING GROUP
RationaleIn COPD, small airway fibrosis occurs due to increased extracellular matrix (ECM) deposition in and around the airway smooth muscle (ASM) layer. Studies of immune cells and peripheral lung tissue have shown that epigenetic changes occur in C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f3909db847312782e8864b7f87650a
https://hdl.handle.net/11370/27cc7406-4155-4cac-95b0-f7016b66b1b5
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4
The role of accelerated ageing in aberrant lung tissue repair and remodelling in COPD
Autor: Roy R Woldhuis
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, while the prevalence is still increasing. Since the exact pathogenesis is still unknown and no therapeutics are available to stop disease progression, novel i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407b7d5911548bb0b922a0f956c76c87
https://research.rug.nl/en/publications/31af37ac-3cab-4663-81a8-23bc127c11fe
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5
Link between increased cellular senescence and extracellular matrix changes in COPD
Autor: Maarten van den Berge, Brian G. Oliver, Irene H. Heijink, Maaike de Vries, Roy R Woldhuis, Corry-Anke Brandsma, Marco Demaria, Wim Timens
Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology, 319(1), L48-L60. AMER PHYSIOLOGICAL SOC
Chronic obstructive pulmonary disease (COPD) is associated with features of accelerated aging, including cellular senescence, DNA damage, oxidative stress, and extracellular matrix (ECM) changes. We propose that these features are particularly appare
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf123aee958cd13c5c45e3a0e7ded03
https://hdl.handle.net/10453/144799
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6
COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins
Autor: Irene H. Heijink, Corry-Anke Brandsma, Roy R Woldhuis, Wim Timens, Maarten van den Berge, Brian G. Oliver, Maaike de Vries
Publikováno v: Thorax
Thorax, 76(5), 508-511. BMJ PUBLISHING GROUP
COPD-derived fibroblasts have increased cellular senescence. Senescent cell accumulation can induce tissue dysfunction by their senescence-associated secretory phenotype (SASP). We aimed to determine the SASP of senescent fibroblasts and COPD-derived
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7085cd29e489a6b991235c1e1067f124
https://pubmed.ncbi.nlm.nih.gov/33273021
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7
Lung tissue gene-expression signature for the ageing lung in COPD
Autor: Roy R Woldhuis, Don D. Sin, Yohan Bossé, Corry-Anke Brandsma, Wim Timens, Tristan V. de Jong, Maarten van den Berge, Victor Guryev, David C. Nickle, Alen Faiz, Dirkje S. Postma, Maaike de Vries
Publikováno v: Thorax, 73(7), 609-617. BMJ PUBLISHING GROUP
IntroductionCOPD is a chronic, progressive, inflammatory disease of the lungs and the third leading cause of death worldwide. The current knowledge of the pathophysiology of COPD is limited and novel insights in underlying disease mechanisms are urge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f92dc00160cf9ca444b1bff550148c3
https://research.rug.nl/en/publications/2f0dbb6c-edeb-49fe-9cd4-d894dd50075b
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9
Elevated VMP1 expression in acute myeloid leukemia amplifies autophagy and is protective against venetoclax-induced apoptosis
Autor: Jan Jacob Schuringa, Edo Vellenga, Fiona A.J. van den Heuvel, Jennifer Jaques, Roy R Woldhuis, Darlyne S Kluit, Hendrik Folkerts, Albertus T. J. Wierenga
Publikováno v: Cell death & disease, 10(6):421. Nature Publishing Group
Cell Death and Disease, Vol 10, Iss 6, Pp 1-12 (2019)
Cell Death & Disease
Vacuole membrane protein (VMP1) is a putative autophagy protein, which together with Beclin-1 acts as a molecular switch in activating autophagy. In the present study the role of VMP1 was analysed in CD34+ cells of cord blood (CB) and primary acute m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add3c845b3fb7bc93b0b50b245b55f16
https://hdl.handle.net/11370/72cfc471-76ce-4022-a2e3-ff8bd4fc73fe
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