Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Roy McGuire"'
Autor:
Csaba Szabó, Daniel J. Smith, Daniel L. Traber, Lillian D. Traber, Andrew L. Salzman, Jeffery Jodoin, Lars J. Bjertnaes, Daniel J. Passerini, Roy McGuire
Publikováno v:
Critical Care Medicine. 33:616-622
ulmonary hypertension is acommon feature in various dis-eases affecting the heart andlungs. Congestive heart failureand chronic obstructive pulmonary dis-ease may well result in pulmonary hyper-tension and ultimately right ventricularfailure if they
Autor:
David N. Herndon, Kazunori Murakami, Hal K. Hawkins, Robert A. Cox, Roy McGuire, Lillian D. Traber, Daniel L. Traber, Jeffrey M. Jodoin, Frank C. Schmalstieg
Publikováno v:
Critical Care Medicine. 31:577-583
The interaction between coagulation and inflammation has become one of the major topics in critical care medicine. In the present study, we investigated the effect of posttreatment of sepsis with recombinant human antithrombin.Experimental laboratory
Autor:
Daniel L. Traber, Kazunori Murakami, Hal K. Hawkins, Lillian D. Traber, Robert A. Cox, Roy McGuire, Frank C. Schmalstieg, David N. Herndon, Lars J. Bjertnaes
Publikováno v:
Critical Care Medicine. 30:2083-2090
Patients with acute lung injury after smoke inhalation often develop pneumonia subsequently complicated by sepsis. This often is a fatal complication. The aim of this study was to develop a standardized and reproducible model of hyperdynamic sepsis a
Autor:
Hal K. Hawkins, Kazunori Murakami, Daniel L. Traber, David N. Herndon, Lars J. Bjertnaes, Robert A. Cox, Lillian D. Traber, Frank C. Schmalstieg, Roy McGuire, Jiro Katahira, Jeffrey M. Jodoin
Publikováno v:
Shock. 18:236-241
Pseudomonas pneumonia is a common complication of smoke inhalation injury. Airway casts formed from clotted mucous occur frequently in this condition. A recent report shows that intravenous heparin improves oxygenation and reduces lung damage in a sh
Autor:
Andrew L. Salzman, Tatsuo Uchida, Csaba Szabó, Daniel L. Traber, Roy McGuire, Lillian D. Traber, Kazutaka Soejima, Ned Snyder
Publikováno v:
Shock. 13:261-266
Recent studies on smoke inhalation injury have been focused on nitric oxide (NO) as an essential factor of progressive lung injury. We studied the effects of inducible nitric oxide synthase (iNOS) inhibition on inhalation injury in sheep. Sheep (n =
Publikováno v:
Clinical Science. 98:193-200
This prospective, non-randomized, controlled experimental study looks at the effects of NΩ-monomethyl-l-arginine (l-NMMA) on haemodynamics, oxygen transport and regional blood flow in healthy and septic sheep, and compares these effects with those o
Autor:
Hans G. Bone, Daniel L. Traber, Roy McGuire, Stefanie R. Fischer, Lillian D. Traber, Paul J. Schenarts
Publikováno v:
Shock. 10:69-76
Cell-free hemoglobin solutions can scavenge nitric oxide and therefore increase mean arterial pressure (MAP). The present study investigated the effects of a continuous low-dose infusion of modified hemoglobin during ovine hyperdynamic sepsis. 13 she
Pyridoxalated hemoglobin polyoxyethylene conjugate reverses hyperdynamic circulation in septic sheep
Autor:
Lillian D. Traber, Paul J. Schenarts, Stefanie R. Fischer, Hans G. Bone, Daniel L. Traber, Roy McGuire
Publikováno v:
Journal of Applied Physiology. 84:1991-1999
We investigated the effects of modified hemoglobin on regional blood flow and function of different organs during hyperdynamic sepsis. Fourteen sheep were surgically prepared for the study. After a 5-day recovery period, a continuous infusion of live
Autor:
Donald J. Deyo, Lillian D. Traber, Stefanie R. Fischer, Roy McGuire, Hans G. Bone, Daniel L. Traber
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 156:833-839
Hypoxic pulmonary vasoconstriction (HPV) is inhibited by inhaled nitric oxide (NO) in healthy animals and is blunted in endotoxemia. We investigated whether the loss of HPV during sepsis could be reversed by NO synthase (NOS) inhibition. Hypoxic chal
Autor:
Donald D. Harper, Michael Booke, Lillian D. Traber, Hans G. Bone, Roy McGuire, Paul J. Schenarts, Daniel L. Traber
Publikováno v:
Critical Care Medicine. 25:1010-1018
Objectives Excessive production of nitric oxide significantly contributes to the hyperdynamic state associated with sepsis. The ability of hemoglobin to scavenge nitric oxide may therefore be beneficial in the treatment of sepsis. In this study, we d