Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Roy Massingham"'
Publikováno v:
Expert Opinion on Therapeutic Patents. 16:13-26
This article analyses the publications and patents on the therapeutic potential of 5-lipoxygenase (5-LOX) inhibitors appearing during the period 2001 – 2004. There have been long-standing attempts to introduce 5-LOX inhibitors for the treatment of
Autor:
Annick Chevalier, Roy Massingham, Michéle Beaughard, Ginette Rispat, Gareth W. John, Ravi Shrivastava, Mohamed Slaoui
Publikováno v:
Toxicology Letters. 73:167-173
The toxicity of isaxonine alone and in combination with the known glutathione depletor, paracetamol, was evaluated using rat hepatocyte primary cultures in vitro by measuring morphometric parameters and the leakage of intracellular lactate dehydrogen
Publikováno v:
Journal of Applied Toxicology. 12:329-332
The toxicity of eleven calcium antagonists from different chemical families was determined in rat hepatocyte primary cultures. The calcium antagonist potency of the same compounds was also determined in isolated rabbit aortic rings contracted with hi
Publikováno v:
Alternatives to Laboratory Animals. 19:393-402
All new chemical entities synthesised in our laboratories have routinely been subjected to in vitro toxicity tests. Out of curiosity, we established a working hypothesis in which the in vitro data could be empirically transformed to predict the in vi
Autor:
Margareta Hammarlund-Udenaes, Pierre Chatelain, E. Niclas Jonsson, Roy Massingham, Anubha Gupta
Publikováno v:
Biopharmaceuticsdrug disposition. 27(6)
Cetirizine, an H1-antihistamine, is prescribed for allergic disorders. It exists as a racemic mixture, with levocetirizine being the active enantiomer. The central nervous system side-effects of H1-antihistamines are caused by their penetration into
Publikováno v:
Rapid communications in mass spectrometry : RCM. 19(12)
Sensitive enantioselective liquid chromatographic assays using tandem mass spectrometric detection were developed and validated for the determination of S-cetirizine (S-CZE) and R-cetirizine (R-CZE) in guinea pig plasma, brain tissue, and microdialys
Publikováno v:
Journal of cardiovascular pharmacology. 26(4)
Experimental canine coronary artery stenosis associated with endothelial injury results in a typical pattern of coronary flow characterized by gradual decreases in blood flow to almost zero values followed by abrupt restorations to original levels. C
Publikováno v:
European journal of pharmacology. 196(3)
Caffeine (1-60 mM) induced concentration-dependent, endothelium-independent phasic contractile responses in isolated rabbit renal artery ring preparations. For concentrations of caffeine over 2 mM, responses were mainly the result of intracellular ca
Publikováno v:
Biochemical pharmacology. 40(7)
Bepridil, a calcium antagonist with anti-anginal, anti-ischemic, and anti-arrhythmic properties was assessed for its ability to scavenge free radicals. Bepridil reduced the stable free radical 1,1-diphenyl-2-picrylhydrazil (DPPH) in the molar ratio 2
Publikováno v:
Toxicology Letters. 88:90-91