Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Roy Kahn"'
Autor:
Ewa Cendrowicz, Lisa Jacob, Shirley Greenwald, Ami Tamir, Iris Pecker, Rinat Tabakman, Lucy Ghantous, Liat Tamir, Roy Kahn, Jasmine Avichzer, Alexandra Aronin, Shira Amsili, Elina Zorde-Khvalevsky, Yosi Gozlan, Martijn Vlaming, Gerwin Huls, Tom van Meerten, Michal Elhalel Dranitzki, Adam Foley-Comer, Yaron Pereg, Amnon Peled, Ayelet Chajut, Edwin Bremer
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-16 (2022)
Abstract Background Treatment of Diffuse Large B Cell Lymphoma (DLBCL) patients with rituximab and the CHOP treatment regimen is associated with frequent intrinsic and acquired resistance. However, treatment with a CD47 monoclonal antibody in combina
Externí odkaz:
https://doaj.org/article/88f427a2882642b7b2f32986f378f0e2
Autor:
Shirley Greenwald, Ayelet Chajut, Alexandra Aronin, Amnon Peled, Matthew Weber, Ami Tamir, Iris Pecker, Rinat Tabakman, Lucy Ganthous, Liat Tamir, Roy Kahn, Jasmine Avichzer, Elina Zorde-Khvalevsky, Michal Michal Elhalel Dranitzki, Adam Foley-Comer, Mark Tykocinski
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/9d1d813fb3514e5b91af359675727c2a
Autor:
Matthew P. Weber, Elina Zorde-Khvalevsky, Amnon Peled, Adam Foley-Comer, Ami Tamir, Ayelet Chajut, Lucy Ganthous, Alexandra Aronin, Rinat Tabakman, Shirley Greenwald, Jasmine Avichzer, Roy Kahn, Mark L. Tykocinski, Iris Pecker, Liat Ben Gigi Tamir, Michal Michal Elhalel Dranitzki
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundTIGIT, an inhibitory immune checkpoint, is a target of interest for immuno-oncology combination therapies. TIGIT is part of a complex molecular network containing four receptors (DNAM1, TIGIT, PVRIG and CD96) and two ligands (PVR and PVRL2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace81f6d30f90242de6e37a20b6a0608
https://doaj.org/article/9d1d813fb3514e5b91af359675727c2a
https://doaj.org/article/9d1d813fb3514e5b91af359675727c2a
Autor:
Todd Scheuer, Vladimir Yarov-Yarovoy, Michael Gurevitz, William A. Catterall, Jinti Wang, Roy Kahn, Dalia Gordon
Publikováno v:
Proceedings of the National Academy of Sciences. 108:15426-15431
The α-scorpions toxins bind to the resting state of Na + channels and inhibit fast inactivation by interaction with a receptor site formed by domains I and IV. Mutants T1560A, F1610A, and E1613A in domain IV had lower affinities for Leiurus quinques
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1909e3ff786e38265a30dea35a5ad228
https://doi.org/10.1073/pnas.1112320108
https://doi.org/10.1073/pnas.1112320108
Publikováno v:
Molecular Biology and Evolution. 27:1025-1034
Alpha-neurotoxins target voltage-gated sodium channels (Na(v)s) and constitute an important component in the venom of Buthidae scorpions. These toxins are short polypeptides highly conserved in sequence and three-dimensional structure, and yet they d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d9f847dc3d265080780788484f8b1e
https://doi.org/10.1093/molbev/msp310
https://doi.org/10.1093/molbev/msp310
Autor:
Yehu Moran, Hagar Weinberger, Dalia Gordon, Maya Gur, Nimrod Lazarus, Roy Kahn, Michael Gurevitz
Publikováno v:
Journal of Molecular Evolution. 69:115-124
Sea anemones are sessile predators that use a variety of toxins to paralyze prey and foe. Among these toxins, Types I, II and III are short peptides that affect voltage-gated sodium channels. Anemonia viridis is the only sea anemone species that prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37477e7cea84c3e3581d44e38725aefd
https://doi.org/10.1007/s00239-009-9258-x
https://doi.org/10.1007/s00239-009-9258-x
Autor:
Dalia Gordon, James C. Sullivan, Adam M. Reitzel, Michael Gurevitz, Yehu Moran, Hagar Weinberger, Roy Kahn, John R. Finnerty
Publikováno v:
Journal of Molecular Biology. 380:437-443
Sea anemones use an arsenal of peptide neurotoxins accumulated in special stinging cells (nematocytes) for defense and predation. Intriguingly, genomic analysis of Nematostella vectensis revealed only a single toxin, Nv1 (N. vectensis toxin 1), encod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f896922f5defc9e3b0060bb51a077ec0
https://doi.org/10.1016/j.jmb.2008.05.011
https://doi.org/10.1016/j.jmb.2008.05.011
Publikováno v:
Biochemical Journal. 406:41-48
Av3 is a short peptide toxin from the sea anemone Anemonia viridis shown to be active on crustaceans and inactive on mammals. It inhibits inactivation of Na(v)s (voltage-gated Na+ channels) like the structurally dissimilar scorpion alpha-toxins and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0640d5725808f8a0d812078a734ec735
https://doi.org/10.1042/bj20070233
https://doi.org/10.1042/bj20070233
Autor:
Maya Gur, Michael Gurevitz, Nitza Ilan, Gerardo Corzo, Stefan H. Heinemann, Oren Froy, Roy Kahn, Nicolas Gilles, Gudrun Albrecht, Izhar Karbat, Lior Cohen, Dalia Gordon
Publikováno v:
FEBS Journal. 274:1918-1931
The affinity of scorpion α-toxins for various voltage-gated sodium channels (Navs) differs considerably despite similar structures and activities. It has been proposed that key bioactive residues of the five-residue-turn (residues 8–12) and the C-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14110ba7ecb5637bc8dfb1d5e87f7c98
https://doi.org/10.1111/j.1742-4658.2007.05737.x
https://doi.org/10.1111/j.1742-4658.2007.05737.x
Autor:
Lior Cohen, Roy Kahn, Walter Stühmer, Michael Turkov, Nitza Ilan, Dalia Gordon, Ke Dong, Izhar Karbat, Michael Gurevitz, Maria Stankiewicz
Publikováno v:
Toxicon. 49:473-489
Voltage-gated sodium channels are a major target for toxins and insecticides due to their central role in excitability, but due to the conservation of these channels in Animalia most insecticides do not distinguish between those of insects and mammal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b8de9354014ec7709cc8dde1a02a64
https://doi.org/10.1016/j.toxicon.2006.11.015
https://doi.org/10.1016/j.toxicon.2006.11.015