Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Roy Jefferis"'
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Intravenous immunoglobulin (IVIG) is used as an immunomodulatory agent in the treatment of various autoimmune/inflammatory diseases although its mechanism of action remains elusive. Recently, nonfucosylated IgG has been shown to be preferentially bou
Externí odkaz:
https://doaj.org/article/0f3ea5484a0c447cbf3cad791e9ff51b
Autor:
Yuval Avnir, Kristina L. Prachanronarong, Zhen Zhang, Shurong Hou, Eric C. Peterson, Jianhua Sui, Hatem Zayed, Vinodh B. Kurella, Andrew T. McGuire, Leonidas Stamatatos, Brendan J. Hilbert, Markus-Frederik Bohn, Timothy F. Kowalik, Jeffrey D. Jensen, Robert W. Finberg, Jennifer P. Wang, Margaret Goodall, Roy Jefferis, Quan Zhu, Nese Kurt Yilmaz, Celia A. Schiffer, Wayne A. Marasco
Publikováno v:
Cell Reports, Vol 21, Iss 11, Pp 3243-3255 (2017)
The heavy chain IGHV1-69 germline gene exhibits a high level of polymorphism and shows biased use in protective antibody (Ab) responses to infections and vaccines. It is also highly expressed in several B cell malignancies and autoimmune diseases. G6
Externí odkaz:
https://doaj.org/article/2bbb54bf6c2c4cf88bc9275ff9a8c706
Autor:
Roy Jefferis
Publikováno v:
Journal of Immunology Research, Vol 2016 (2016)
Whilst the amino acid sequence of a protein is determined by its gene sequence, the final structure and function are determined by posttranslational modifications (PTMs), including quality control (QC) in the endoplasmic reticulum (ER) and during pas
Externí odkaz:
https://doaj.org/article/1fd8798e208a4c0d8f5f837e81f708bd
Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then comp
Autor:
Khalil Abu Hammad, Vlad Dinu, Thomas E. MacCalman, Jacob Pattem, Margaret Goodall, Richard B. Gillis, Roy Jefferis, Stephen E. Harding
Publikováno v:
European Biophysics Journal.
The solution properties of two different glycoforms of IgG1 (IgG1Cri and IgG1Wid) are compared using primarily sedimentation equilibrium analysis with two complementary analysis routines: SEDFIT-MSTAR and MULTISIG. IgGCri bears diantennary complex-ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d26dee534ca0bb7f04cf58f0a65471ff
https://doi.org/10.1007/s00249-023-01656-x
https://doi.org/10.1007/s00249-023-01656-x
Publikováno v:
Experientia supplementum (2012). 112
Therapeutic monoclonal antibodies (mAbs) are mostly of the IgG class and constitute highly efficacious biopharmaceuticals for a wide range of clinical indications. Full-length IgG mAbs are large proteins that are subject to multiple posttranslational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aa2105c48d589cb96221f2b1c4d25ee6
https://pubmed.ncbi.nlm.nih.gov/34687006
https://pubmed.ncbi.nlm.nih.gov/34687006
Autor:
Roy Jefferis
Publikováno v:
Journal of Prescribing Practice. 1:26-31
The bench-to-bedside ideal is being realised for both humoral and cellular immunotherapy. Monoclonal antibodies (mAbs) are established in the clinic, but continuous development has resulted in progression from mouse/human chimeric to humanised, ‘fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2e9edf03f034e8dcf3b60152df7a290
https://doi.org/10.12968/jprp.2019.1.1.26
https://doi.org/10.12968/jprp.2019.1.1.26
Publikováno v:
Experientia Supplementum ISBN: 9783030769116
The complex diantennary-type oligosaccharides at Asn297 residues of the IgG heavy chains have a profound impact on the safety and efficacy of therapeutic IgG monoclonal antibodies (mAbs). Fc glycosylation of a mAb is an established critical quality a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1360314bb146ed2b4051a4d44413f4c
https://doi.org/10.1007/978-3-030-76912-3_15
https://doi.org/10.1007/978-3-030-76912-3_15
Publikováno v:
Experientia Supplementum ISBN: 9783030769116
Therapeutic monoclonal antibodies (mAbs) are mostly of the IgG class and constitute highly efficacious biopharmaceuticals for a wide range of clinical indications. Full-length IgG mAbs are large proteins that are subject to multiple posttranslational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8629646096aaca04a2100daf8b6f0913
https://doi.org/10.1007/978-3-030-76912-3_1
https://doi.org/10.1007/978-3-030-76912-3_1