Biochemical and Electroretinographic Characterization of the Minipig Eye in the Context of Drug Safety Investigations

Autor: Michelle Dubuc-Mageau, Audrey Sanfacon, Andy Makin, Robert Tavcar, Christian Li, Luis Fernando Negro Silva, Roy Forster, Simon Authier, Paula Juliana Brizuela de Seadi Pereira, Wendy Tan

Publikováno v: International Journal of Toxicology. 38:415-422

Minipigs are an emerging nonrodent alternative for ocular toxicology owing to anatomical similarities in the minipig eyes when compared to humans. Ocular structures and components from Göttingen minipigs were characterized and compared to species co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0858396b33f2edb6685bf9ce62af18
https://doi.org/10.1177/1091581819867929

Assessment of phototoxicity in pigmented Long-Evans rat: sparfloxacin and 8-methoxypsoralen

Autor: Cédric Gerbeix, Roy Forster, Nick Pearson, Stephen Turnock, Catherine Thirion-Delalande

Publikováno v: Regulatory Toxicology and Pharmacology. 92:303-314

The aim of the present work was to evaluate the effects of photo-activated toxicity induced after administration of two known melanin-binding phototoxic compounds, sparfloxacin (SPX) and 8-methoxypsoralen (8-MOP), followed or not by UVA/Vis exposure,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddfcba8463d1240a5e8e38b706a04155
https://doi.org/10.1016/j.yrtph.2017.11.014

Intranodal Angiomyomatous Hamartoma in a Cynomolgus Monkey

Autor: Roy Forster, Bernard Palate, Catherine Thirion-Delalande, Frédéric Gervais, André Almeida Schenka

Publikováno v: Toxicologic pathology. 47(2)

We describe here an angiomyomatous hamartoma in the right axillary lymph node of a three-year-old male cynomolgus monkey ( Macaca fascicularis), used as a control subject in a short-term toxicity study. This is a very rare lesion that has been report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7dbce27a7fa735db25c3f478897f538
https://pubmed.ncbi.nlm.nih.gov/30585127

QT interval correction for drug-induced changes in body temperature during integrated cardiovascular safety assessment in regulatory toxicology studies in dogs: A case study

Autor: Roy Forster, Francine El Amrani-Callens, Abdel-Ilah El Amrani, Stéphane Loriot, Pramila Singh

Publikováno v: Journal of Pharmacological and Toxicological Methods. 81:136-143

Introduction Cardiovascular safety assessment requires accurate evaluation of QT interval, which depends on the length of the cardiac cycle and also on core body temperature (BT). Increases in QT interval duration have been shown to be associated wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d2b9529a5e11b7f6a522ea554f243a

In vitro human placental studies to support an adenovirusmediated VEGF-DΔNΔC maternal gene therapy for the treatment of severe early-onset fetal growth restriction

Autor: Susan L. Greenwood, Neil J. Sebire, Roy Forster, Elena Olearo, Michelle Desforges, Carlo Rossi, Paul Brownbill, Alexandra Rogue, Mark Lees, Anna L. David, Nick Pearson, Colin P. Sibley

Publikováno v: Desforges, M, Rogue, AR, Pearson, N, Rossi, C, Olearo, E, Forster, R, Lees, M, Sebire, N, Greenwood, S, Sibley, C, David, AL & Brownbill, P 2018, ' In vitro human placental studies to support an adenovirusmediated VEGF-DΔNΔC maternal gene therapy for the treatment of severe early-onset fetal growth restriction ', Human gene therapy. Clinical development . https://doi.org/10.1089/humc.2017.090

Severe fetal growth restriction (FGR) affects 1 in 500 pregnancies, is untreatable, and causes serious neonatal morbidity and death. Reduced uterine blood flow (UBF) is one cause. Transduction of u...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bbc14d1b6e41fb1c6ac8ffd1da56f91
https://doi.org/10.1089/humc.2017.090