Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Roy Drissen"'
Autor:
Simona Valletta, Alexander Thomas, Yiran Meng, Xiying Ren, Roy Drissen, Hilal Sengül, Cristina Di Genua, Claus Nerlov
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Ageing of the haematopoietic system is accompanied by declining erythropoiesis and lymphopoiesis. Here the authors uncover upregulated IL-6 and TGFβ signalling in aged bone marrow stroma; inhibition of these signals reverses age-related haematopoiet
Externí odkaz:
https://doaj.org/article/d92c05c8ae8e4f60abab394fce4e0c0b
Autor:
Theodore P. Braun, Mariam Okhovat, Cody Coblentz, Sarah A. Carratt, Amy Foley, Zachary Schonrock, Brittany M. Smith, Kimberly Nevonen, Brett Davis, Brianna Garcia, Dorian LaTocha, Benjamin R. Weeder, Michal R. Grzadkowski, Joey C. Estabrook, Hannah G. Manning, Kevin Watanabe-Smith, Sophia Jeng, Jenny L. Smith, Amanda R. Leonti, Rhonda E. Ries, Shannon McWeeney, Cristina Di Genua, Roy Drissen, Claus Nerlov, Soheil Meshinchi, Lucia Carbone, Brian J. Druker, Julia E. Maxson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Acute Myeloid Leukemia (AML) develops following multiple mutations of differing impact. Here, the authors show that activating mutations of CSF3R co-operate with loss-of-function mutations of CEBPA to promote AML development through an enhancer-depen
Externí odkaz:
https://doaj.org/article/c4f5920cda714e2080bbc04d4c0c3d87
Autor:
Theodore P. Braun, Mariam Okhovat, Cody Coblentz, Sarah A. Carratt, Amy Foley, Zachary Schonrock, Brittany M. Curtiss, Kimberly Nevonen, Brett Davis, Brianna Garcia, Dorian LaTocha, Benjamin R. Weeder, Michal R. Grzadkowski, Joey C. Estabrook, Hannah G. Manning, Kevin Watanabe-Smith, Sophia Jeng, Jenny L. Smith, Amanda R. Leonti, Rhonda E. Ries, Shannon McWeeney, Cristina Di Genua, Roy Drissen, Claus Nerlov, Soheil Meshinchi, Lucia Carbone, Brian J. Druker, Julia E. Maxson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/c3c2338ac9144f60aac72e27a406a213
Autor:
Cristina Di Genua, Ruggiero Norfo, Alba Rodriguez-Meira, Wei Xiong Wen, Roy Drissen, Christopher A.G. Booth, Benjamin Povinelli, Emmanouela Repapi, Nicki Gray, Joana Carrelha, Laura M. Kettyle, Lauren Jamieson, Wen Hao Neo, Supat Thongjuea, Claus Nerlov, Adam J. Mead
Publikováno v:
Haematologica, Vol 104, Iss 11 (2019)
Somatic mutations in acute myeloid leukemia are acquired sequentially and hierarchically. First, pre-leukemic mutations, such as t(8;21) that encodes AML1-ETO, are acquired within the hematopoietic stem cell (HSC) compartment, while signaling pathway
Externí odkaz:
https://doaj.org/article/63c14c0940654124844eb28a1e97c816
Autor:
Yiran Meng, Joana Carrelha, Roy Drissen, Xiying Ren, Bowen Zhang, Adriana Gambardella, Simona Valletta, Supat Thongjuea, Sten Eirik Jacobsen, Claus Nerlov
Publikováno v:
Nature Cell Biology.
Haematopoietic stem cells (HSCs) are multipotent, but individual HSCs can show restricted lineage output in vivo. Currently, the molecular mechanisms and physiological role of HSC fate restriction remain unknown. Here we show that lymphoid fate is ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df5e1dde48e353f9997d05d6b7ec448
https://doi.org/10.1038/s41556-023-01137-5
https://doi.org/10.1038/s41556-023-01137-5
Autor:
Roy Drissen, Claus Nerlov
Publikováno v:
Experimental Hematology. 111:S82
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34e78791a917ebf5ca7a31b86288ce39
https://doi.org/10.1016/j.exphem.2022.07.131
https://doi.org/10.1016/j.exphem.2022.07.131
Autor:
Yiran Meng, Joana Carrelha, Roy Drissen, Adriana Gambardella, Supat Thongjuea, Sten Eirik Jacobsen, Claus Nerlov
Publikováno v:
Experimental Hematology. 111:S50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4510362e2baab270348c183266d6fa9
https://doi.org/10.1016/j.exphem.2022.07.067
https://doi.org/10.1016/j.exphem.2022.07.067
Autor:
Michal R. Grzadkowski, Jenny L. Smith, Mariam Okhovat, Benjamin R. Weeder, Rhonda E. Ries, Brianna Garcia, Roy Drissen, Shannon K. McWeeney, Cristina Di Genua, Joey C. Estabrook, Kevin Watanabe-Smith, Brittany M. Smith, Zachary Schonrock, Kimberly A. Nevonen, Julia E. Maxson, Sarah A. Carratt, Amy Foley, Dorian LaTocha, Lucia Carbone, Brian J. Druker, Amanda R. Leonti, Hannah G. Manning, Sophia Jeng, Claus Nerlov, Brett Davis, Soheil Meshinchi, Cody Coblentz, Theodore P. Braun
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Acute Myeloid Leukemia (AML) develops due to the acquisition of mutations from multiple functional classes. Here, we demonstrate that activating mutations in the granulocyte colony stimulating factor receptor (CSF3R), cooperate with loss of function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c106d9ac7706c8a849e220926dc5117
https://pubmed.ncbi.nlm.nih.gov/35710794
https://pubmed.ncbi.nlm.nih.gov/35710794
Human myelopoiesis has been proposed to occur through oligopotent common myeloid progenitor (CMP) and lymphoid-primed multipotent progenitor (LMPP) populations. However, other studies have proposed direct commitment of multipotent cells to unilineage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::137f28b310dc0507f5e864ac52d0cec6
https://ora.ox.ac.uk/objects/uuid:f2cb7cd6-1b05-4a8d-8b96-e0ada7375808
https://ora.ox.ac.uk/objects/uuid:f2cb7cd6-1b05-4a8d-8b96-e0ada7375808
Publikováno v:
Brain-Derived Neurotrophic Factor (BDNF) ISBN: 9781493989690
High-throughput next generation sequencing technologies are an invaluable tool to gain insight into the transcriptional states of large cohorts of cells. Such data can help to shed light on the organization of tissues and pathways under normal and pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d790e9eb9c9a74be92196aab7305609f
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid: