Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Roy D. LeGrand"'
Publikováno v:
Applied Biochemistry and Biotechnology. 94:71-96
Advanced glycation end products (AGEs) and, specifically, protein-protein AGE crosslinks have long been studied for their potential role in aging, diabetic complications and Alzheimer disease. With few exceptions, the chemical nature of these structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a345065a9fd4e26873da63bb3e42c931
https://doi.org/10.1385/abab:94:1:71
https://doi.org/10.1385/abab:94:1:71
Autor:
Mikhail Linetsky, Roy D. LeGrand
Publikováno v:
Molecular and cellular biochemistry. 272(1-2)
Formation of lanthionine, a dehydroalanine crosslink, is associated with aging of the human lens and cataractogenesis. In this study we investigated whether modification of lens proteins by glutathione could proceed through an alternative pathway: th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e2daba5fadc48d8130f0e6b92d92a5
https://pubmed.ncbi.nlm.nih.gov/16010980
https://pubmed.ncbi.nlm.nih.gov/16010980
Publikováno v:
Biochimica et biophysica acta. 1724(1-2)
Under the chromatographic conditions used in these studies we observed time- and concentration-dependent formation of N-1-Deoxy-fructos-1-yl glutathione as the major glycation product formed in the mixtures of GSH with glucose. N-1-Deoxy-fructos-1-yl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f527fce95d6b26aafc16556d5825bb4f
https://pubmed.ncbi.nlm.nih.gov/15893878
https://pubmed.ncbi.nlm.nih.gov/15893878
Publikováno v:
Experimental eye research. 79(4)
This study was conducted to develop a methodology for the purification and detection of histidinoalanine, lanthionine and lysinoalanine in the lens tissue. Cataractous and aged human lens proteins were hydrolysed and fractionated by using anion-excha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2e29692e8a875ef3f93eee57856c2e
https://pubmed.ncbi.nlm.nih.gov/15381034
https://pubmed.ncbi.nlm.nih.gov/15381034
Publikováno v:
Cellular immunology. 145(1)
We have determined that Pseudomonas aeruginosa exotoxin A (PE) can selectively stimulate the proliferation of V beta bearing T lymphocytes. Murine thymocytes were fractionated by selective agglutination with peanut agglutinin (PNA) and the PNA- thymo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255ccad9444e73de3919e6a3294f860a
https://pubmed.ncbi.nlm.nih.gov/1358461
https://pubmed.ncbi.nlm.nih.gov/1358461
Publikováno v:
Infection and immunity. 60(4)
Pseudomonas aeruginosa exotoxin A (PE) represents a microbial superantigen that requires processing by accessory cells in order to induce the proliferation of V beta 8-bearing murine T lymphocytes. In this study, we have observed that PE requires int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1eb7152277866871e5e2a2da407ac9
https://pubmed.ncbi.nlm.nih.gov/1548056
https://pubmed.ncbi.nlm.nih.gov/1548056
Publikováno v:
Cellular immunology. 135(2)
We have examined the functions required of accessory cells (AC) for murine thymocyte proliferation induced by Pseudomonas exotoxin A (PE) and have compared these functions to those required of a known superantigen, staphylococcal enterotoxin B (SEB).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9742f1d4e43ace0048571347e8350b
https://pubmed.ncbi.nlm.nih.gov/1903675
https://pubmed.ncbi.nlm.nih.gov/1903675
Autor:
Ronald J. Walkenbach, Roy D. LeGrand
Publikováno v:
Experimental eye research. 34(2)
Adenylate cyclase activity in bovine corneal epithelial or rat kidney particulate fractions was completely inhibited by clinically employed levels of anti-inflammatory steroids. Dose-response studies using several steroids showed that dexamethasone p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4e84afc20ae92ba274a9b24302da7b
https://pubmed.ncbi.nlm.nih.gov/6277681
https://pubmed.ncbi.nlm.nih.gov/6277681
Autor:
Roy D. LeGrand, Ronald J. Walkenbach
Publikováno v:
Experimental eye research. 33(1)
Bovine corneas were treated in vitro with various drug regimens and cyclic AMP, protein kinase and glycogen synthase activities were determined in each tissue extract. Isoproterenol (alone) did not increase corneal cyclic AMP under any condition test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7898b14cc781788f48cc2d198e87c6
https://pubmed.ncbi.nlm.nih.gov/6166493
https://pubmed.ncbi.nlm.nih.gov/6166493